Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFQX1U)

Drug Name

EMATE Drug Info

Synonyms

Emate compound; Estrone 3-O-Sulfamate; EMATE; Estrone-3-O-sulfamate; Oestrone-3-O-sulphamate; 148672-09-7; Estra-1,3,5(10)-trien-17-one-3-sulfamate; CHEMBL122708; 3-((Aminosulfonyl)oxy)estra-1,3,5(10)-trien-17-one; C18H23NO4S; 3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one; Estra-1,3,5(10)-trien-17-one, 3-((aminosulfonyl)oxy)-; Estrone Sulfamate; estrone3-O-sulfamate; NSC685426; Estrone O-Sulfamate; Estrone 3-Sulfamate; AC1L2SFZ; SCHEMBL305660; CTK8F0296; RVKFQAJIXCZXQY-CBZIJGRNSA-N; ZINC5832614; BDBM50134329; AKOS030241107

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 127676
CAS Number: CAS 148672-09-7
TTD Drug ID: DMFQX1U

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[5]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[6]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[7]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[8]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[8]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[9]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[10]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[11]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[12]
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Drug(s) Targeting Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tranilast	DME5Y64	Allergic rhinitis	CA08.0	Approved	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
STX-140	DMJK5CT	Osteoporosis	FB83.0	Phase 2	[2]
PGL-2001	DMKA705	Endometriosis	GA10	Phase 2	[15]
PGL-2	DMJTYO4	Endometriosis	GA10	Phase 2	[15]
STX 64	DMJAPRK	Prostate cancer	2C82.0	Phase 1	[16]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[17]
Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester	DMM70K1	Discovery agent	N.A.	Investigative	[18]
Estradiol 17-O-sulfamate	DM7K14V	Discovery agent	N.A.	Investigative	[2]
4-Sulfamoyloxy-benzoic acid pentyl ester	DMZIFW7	Discovery agent	N.A.	Investigative	[19]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[24]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[25]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[30]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[39]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Steryl-sulfatase (STS)	TTHM0R1	STS_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Post-Translational Modifications	[3]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[3]

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References

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30	4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
31	Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
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39	-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.