Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHW93J)

• Drug Name: Phenylglyoxal Drug Info
• Synonyms: Benzeneacetaldehyde, .alpha.-oxo-; OJUGVDODNPJEEC-UHFFFAOYSA-N; Oxo(phenyl)acetaldehyde; Oxo-phenyl-acetaldehyde; Phenyl glyoxal; alpha-oxobenzeneacetaldehyde; benzoylcarboxaldehyde; benzoylformaldehyde; glyoxal, phenyl-; phenylethanedione; phenylglyoxal; 1074-12-0; 2-oxo-2-phenyl-acetaldehyde; 2-oxo-2-phenylacetaldehyde; AI3-22132; BRN 1854721; CCRIS 966; CHEBI:88868; EINECS 214-036-1; MFCD00006959; N45G3015PA; NSC 156299; NSC 26909; NSC627436; UNII-N45G3015PA; benzeneacetaldehyde, alpha-oxo-, monohydrate
• Cross-matching ID:
  PubChem CID: 14090
  ChEBI ID: CHEBI:88868
  CAS Number: CAS 1074-12-0
  TTD Drug ID: DMHW93J
  INTEDE Drug ID: DR2120

Molecule-Related Drug Atlas

Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[12]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[13]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[10]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[12]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[17]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[21]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[12]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[22]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[13]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[24]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[11]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[23]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[25]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Maillard deglycase (PARK7) Main DME	DEPOVCH	PARK7_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member A1 (AKR1A1)	OTZT9NOW	AK1A1_HUMAN	Biotransformations	[2]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Biotransformations	[2]
Alpha-(1,6)-fucosyltransferase (FUT8)	OTJJCVG1	FUT8_HUMAN	Gene/Protein Processing	[3]
Dehydrogenase/reductase SDR family member 11 (DHRS11)	OTU3J0ZL	DHR11_HUMAN	Biotransformations	[4]

References

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