Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLT4JA)

• Drug Name: UDP-glucose Drug Info
• Synonyms: Uridine-5'-diphosphate-glucose; URIDINE DIPHOSPHATE GLUCOSE; UDPG; UDP-alpha-D-Glucose; 133-89-1; UNII-V50K1D7P4Y; URIDINE-5'-DIPHOSPHATE-GLUCOSE; 5'-Diphosphoglucose; UDP-D-glucose; GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE; UDPglucose; V50K1D7P4Y; CHEBI:46229; URIDINE-5'-DIPHOSPHOGLUCOSE; UDP-Glc; Uridine diphosphoglucose; Uridine 5'-diphosphoglucose; co-waldenase; URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER; co-galactoisomerase; [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]; uridine diphosphate glucose; Glucose-Uridine-C1,5'-Diphosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 8629
  ChEBI ID: CHEBI:46229
  CAS Number: CAS 133-89-1
  TTD Drug ID: DMLT4JA
  VARIDT Drug ID: DR00178
  INTEDE Drug ID: DR2133

Molecule-Related Drug Atlas

Drug(s) Targeting P2Y purinoceptor 14 (P2RY14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UDP-glucuronic acid	DMW16X2	Discovery agent	N.A.	Investigative	[7]
PPTN	DML72JT	Discovery agent	N.A.	Investigative	[8]
2-thio-UDP	DM84R6C	Discovery agent	N.A.	Investigative	[9]
MRS2905	DMGCPHO	Discovery agent	N.A.	Investigative	[10]
MRS2690	DMNS3RT	Discovery agent	N.A.	Investigative	[11]
alpha.beta-methylene-2-thio-UDP	DMLGMTQ	Discovery agent	N.A.	Investigative	[9]
MRS2802	DMWKZCY	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LTE4	DMCPB0Q	Discovery agent	N.A.	Investigative	[12]
LTC4	DM702WR	Discovery agent	N.A.	Investigative	[3]
LTD4	DMIUZX3	Discovery agent	N.A.	Investigative	[3]
ASN04421891	DMC82XN	Discovery agent	N.A.	Investigative	[13]
ASN04450772	DMKR69T	Discovery agent	N.A.	Investigative	[13]
ASN06917370	DMA20JP	Discovery agent	N.A.	Investigative	[13]
ASN02563583	DMEO3Y4	Discovery agent	N.A.	Investigative	[13]
ASN04885796	DMQ0VZ8	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[14]
Uridine Diphosphate Galactose	DMPA0BJ	Discovery agent	N.A.	Investigative	[15]
Uridine-Diphosphate-N-Acetylgalactosamine	DMXHO6J	N. A.	N. A.	Investigative	[1]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[16]
Tetramethylammonium Ion	DMLEPYN	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Diphosphate	DMDQKJB	Discovery agent	N.A.	Investigative	[1]
Phenyl-Uridine-5'-Diphosphate	DM7J0YG	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Diphosphate-Mannose	DMAYCQU	Discovery agent	N.A.	Investigative	[1]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 14 (P2RY14)	TT72OKI	P2Y14_HUMAN	Agonist	[2]
UDP-glucose 4-epimerase (GALE)	TTGRHIB	GALE_HUMAN	Inhibitor	[1]
Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)	TTMPART	GPR17_HUMAN	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (SLC35D2)	DTOUNZE	S35D2_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucose 6-dehydrogenase (UGDH) Main DME	DE48Q2Z	UGDH_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
UDP-glucose 4-epimerase (GALE)	OTVFS16E	GALE_HUMAN	Protein Interaction/Cellular Processes	[6]

References

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• [21] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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