Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLT4JA)

• Drug Name: UDP-glucose Drug Info
• Synonyms: Uridine-5'-diphosphate-glucose; URIDINE DIPHOSPHATE GLUCOSE; UDPG; UDP-alpha-D-Glucose; 133-89-1; UNII-V50K1D7P4Y; URIDINE-5'-DIPHOSPHATE-GLUCOSE; 5'-Diphosphoglucose; UDP-D-glucose; GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE; UDPglucose; V50K1D7P4Y; CHEBI:46229; URIDINE-5'-DIPHOSPHOGLUCOSE; UDP-Glc; Uridine diphosphoglucose; Uridine 5'-diphosphoglucose; co-waldenase; URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER; co-galactoisomerase; [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]; uridine diphosphate glucose; Glucose-Uridine-C1,5'-Diphosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 8629
  ChEBI ID: CHEMBL375951
  CAS Number: CAS 133-89-1
  TTD Drug ID: DMLT4JA
  VARIDT Drug ID: DR00178
  INTEDE Drug ID: DR2133

Molecule-Related Drug Atlas

Drug(s) Targeting P2Y purinoceptor 14 (P2RY14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UDP-glucuronic acid	DMW16X2	Discovery agent	N.A.	Investigative	[6]
PPTN	DML72JT	Discovery agent	N.A.	Investigative	[7]
2-thio-UDP	DM84R6C	Discovery agent	N.A.	Investigative	[8]
MRS2905	DMGCPHO	Discovery agent	N.A.	Investigative	[9]
MRS2690	DMNS3RT	Discovery agent	N.A.	Investigative	[10]
alpha.beta-methylene-2-thio-UDP	DMLGMTQ	Discovery agent	N.A.	Investigative	[8]
MRS2802	DMWKZCY	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LTE4	DMCPB0Q	Discovery agent	N.A.	Investigative	[11]
LTC4	DM702WR	Discovery agent	N.A.	Investigative	[3]
LTD4	DMIUZX3	Discovery agent	N.A.	Investigative	[3]
ASN04421891	DMC82XN	Discovery agent	N.A.	Investigative	[12]
ASN04450772	DMKR69T	Discovery agent	N.A.	Investigative	[12]
ASN06917370	DMA20JP	Discovery agent	N.A.	Investigative	[12]
ASN02563583	DMEO3Y4	Discovery agent	N.A.	Investigative	[12]
ASN04885796	DMQ0VZ8	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[13]
Uridine Diphosphate Galactose	DMPA0BJ	Discovery agent	N.A.	Investigative	[14]
Uridine-Diphosphate-N-Acetylgalactosamine	DMXHO6J	N. A.	N. A.	Investigative	[1]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[15]
Tetramethylammonium Ion	DMLEPYN	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Diphosphate	DMDQKJB	Discovery agent	N.A.	Investigative	[1]
Phenyl-Uridine-5'-Diphosphate	DM7J0YG	Discovery agent	N.A.	Investigative	[1]
Uridine-5'-Diphosphate-Mannose	DMAYCQU	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 14 (P2RY14)	TT72OKI	P2Y14_HUMAN	Agonist	[2]
UDP-glucose 4-epimerase (GALE)	TTGRHIB	GALE_HUMAN	Inhibitor	[1]
Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)	TTMPART	GPR17_HUMAN	Agonist	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (SLC35D2)	DTOUNZE	S35D2_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucose 6-dehydrogenase (UGDH) Main DME	DE48Q2Z	UGDH_HUMAN	Substrate	[5]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics. 2001 Dec;78(3):124-8.
• [3] The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27.
• [4] Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Genomics. 2005 Jan;85(1):106-16.
• [5] Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. J Biol Chem. 2004 Sep 3;279(36):37491-8.
• [6] Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8.
• [7] A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9.
• [8] Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.
• [9] Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.
• [10] The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 Mar;9(1):31-40.
• [11] The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One. 2008;3(10):e3579.
• [12] In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52.
• [13] Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7.
• [14] Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502.
• [15] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.