Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLWZRT)

• Drug Name: CID16020046 Drug Info
• Synonyms: CID 16020046

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 16020046
  CAS Number: CAS 834903-43-4
  TTD Drug ID: DMLWZRT

Molecule-Related Drug Atlas

Drug(s) Targeting G-protein coupled receptor 55 (GPR55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[4]
BIO-017	DMYHK3Y	Angelman syndrome	LD90.0	Phase 1	[5]
N-oleoylethanolamide	DMJQ4L7	Discovery agent	N.A.	Investigative	[4]
[3H]CP55940	DMU7FC5	Discovery agent	N.A.	Investigative	[4]
lysophosphatidylinositol	DMETM3R	Discovery agent	N.A.	Investigative	[6]
O-1602	DM9VISB	Discovery agent	N.A.	Investigative	[7]
abnormal cannabidiol	DMV6DAO	Discovery agent	N.A.	Investigative	[4]
O-arachidonoyl ethanolamine	DML0P72	Discovery agent	N.A.	Investigative	[4]
CID1172084	DMK6YOP	Discovery agent	N.A.	Investigative	[8]
2-arachidonyl glyceryl ether	DM2H8TV	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[9]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[10]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[11]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[12]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[13]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[18]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[28]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[31]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[32]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 55 (GPR55)	TTNET8J	GPR55_HUMAN	Antagonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[3]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Gene/Protein Processing	[3]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Gene/Protein Processing	[3]

References

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• [4] The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101.
• [5] Clinical pipeline report, company report or official report of Biom Therapeutics
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• [17] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [18] Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
• [19] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [20] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [21] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
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• [35] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
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• [37] Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.