Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM61Y2)

• Drug Name: BRL-15572 Drug Info
• Synonyms: BRL15572; BRL-15,572; BRL 15572

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3654103
  ChEBI ID: CHEBI:64060
  CAS Number: CAS 734517-40-9
  TTD Drug ID: DMM61Y2

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 1B receptor (HTR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[3]
Eletriptan	DMW649X	Migraine	8A80	Approved	[4]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[4]
Frovatriptan	DM7RE8P	Migraine	8A80	Approved	[4]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[4]
Naratriptan	DMO50U2	Headache	8A80-8A84	Approved	[5]
Prolixin decanoate	DMMJ1IS	Schizophrenia	6A20	Approved	[4]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[6]
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[7]
[N-methyl-3H(3)]AZ-10419369	DMSCV02	Mood disorder	6A60-6E23	Phase 1	[8]

Drug(s) Targeting 5-HT 1D receptor (HTR1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[9]
Eletriptan	DMW649X	Migraine	8A80	Approved	[4]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[4]
Frovatriptan	DM7RE8P	Migraine	8A80	Approved	[4]
Sumatriptan	DMVYXR8	Cluster headache	8A81.0	Approved	[10]
Rizatriptan	DMDJMA3	Migraine	8A80	Approved	[11]
Almogran	DM7I64Z	Migraine	8A80	Approved	[12]
Neu-P11	DMIQDFW	Alzheimer disease	8A20	Phase 2	[13]
FKB01MD	DM2O7NM	N. A.	N. A.	Phase 2	[14]
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[7]

Drug(s) Targeting 5-HT 6 receptor (HTR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LU AE58054	DMWGRQD	Schizophrenia	6A20	Phase 3	[15]
SB-742457	DM6L4ZT	Alzheimer disease	8A20	Phase 3	[16]
AVN 211	DMVB4OS	Schizophrenia	6A20	Phase 2/3	[17]
SYN120	DMDF7XB	Parkinson disease	8A00.0	Phase 2	[18]
AVN 101	DMJFLBC	Alzheimer disease	8A20	Phase 2	[17]
SYN-120	DMPW0UL	Alzheimer disease	8A20	Phase 2	[19]
PF-05212377	DMPVQYR	Alzheimer disease	8A20	Phase 2	[20]
AVN 322	DMK2LGM	Cognitive impairment	6D71	Phase 2	[16]
SAM-531	DMHVJZ6	Alzheimer disease	8A20	Phase 2	[21]
SUVN-502	DMQD753	Alzheimer disease	8A20	Phase 2	[22]

Drug(s) Targeting 5-HT 2B receptor (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[23]
Triflupromazine	DMKFQJP	Nausea	MD90	Approved	[24]
Minaprine	DM0EP7M	Depression	6A70-6A7Z	Approved	[25]
SPN-812	DMTV7XH	Attention deficit hyperactivity disorder	6A05.Z	Phase 4	[26]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[27]
PRX-08066	DMR7H2V	Pulmonary arterial hypertension	BB01.0	Phase 2	[28]
Pyrimidine derivative 29	DMVOYJ8	N. A.	N. A.	Patented	[29]
Pyrimidine derivative 26	DM90WKN	N. A.	N. A.	Patented	[29]
Pyrimidine derivative 23	DM5MLQU	N. A.	N. A.	Patented	[29]
Pyrimidine derivative 25	DM51MFS	N. A.	N. A.	Patented	[29]

Drug(s) Targeting 5-HT 2A receptor (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[23]
ZOTEPINE	DMF3VXA	Anxiety disorder	6B00-6B0Z	Approved	[30]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[31]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[32]
Lurasidone hydrochloride	DMCVPXO	Schizophrenia	6A20	Approved	[33]
Aniracetam	DMOIFW0	Cerebrovascular ischaemia	8B1Z	Approved	[34]
lumateperone tosylate	DMQ8HOJ	Schizophrenia	6A20	Approved	[35]
Sarpogrelate	DMGLP6S	Diabetic complication	5A2Y	Approved	[36]
Pimavanserin	DMR7IVC	Parkinson disease	8A00.0	Approved	[37]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[38]

Drug(s) Targeting 5-HT 1F receptor (HTR1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[39]
Lasmiditan	DMXLVDT	Migraine	8A80	Approved	[40]
LY-334370	DM43O9N	Migraine	8A80	Phase 2	[41]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[39]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[42]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[39]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[42]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[42]
WAY-466	DMMOH51	Discovery agent	N.A.	Investigative	[43]
[125I]LSD	DMP69QG	Discovery agent	N.A.	Investigative	[44]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[4]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[45]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[46]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[47]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[32]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[48]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[49]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[50]
Treximet	DMU54QB	Migraine	8A80	Approved	[51]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[52]

Drug(s) Targeting 5-HT 2C receptor (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[23]
Lorcaserin	DMG6OYJ	Obesity	5B81	Approved	[53]
Tramadol	DMRQD04	Osteoarthritis	FA00-FA05	Approved	[54]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[56]
Methysergide	DM1EF73	Migraine	8A80	Approved	[57]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[6]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[58]
SR46349B	DM1ODMR	Primary insomnia	7A00	Phase 3	[59]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[27]

Drug(s) Targeting 5-HT 1E receptor (HTR1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[60]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[60]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[60]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[60]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[42]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[60]
m-chlorophenylpiperazine	DMM1J2D	Discovery agent	N.A.	Investigative	[60]
EDMT	DMS3AXK	Discovery agent	N.A.	Investigative	[61]
9-OH-risperidone	DMGORXQ	Discovery agent	N.A.	Investigative	[62]
[3H]5-HT	DMYJXV7	Discovery agent	N.A.	Investigative	[63]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Agonist	[2]
5-HT 1B receptor (HTR1B)	TTK8CXU	5HT1B_HUMAN	Agonist	[2]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Agonist	[2]
5-HT 1E receptor (HTR1E)	TTCPG9S	5HT1E_HUMAN	Agonist	[2]
5-HT 1F receptor (HTR1F)	TT0MI3F	5HT1F_HUMAN	Agonist	[2]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Agonist	[2]
5-HT 2B receptor (HTR2B)	TT0K1SC	5HT2B_HUMAN	Agonist	[2]
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Agonist	[2]
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Agonist	[2]

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