Details of the Drug-Related molecule(s) Interaction Atlas

Diacerein Drug Info

Diacerein; 13739-02-1; Diacetylrhein; Diacerhein; Fisiodar; Artrodar; 1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE; DIACERIN; 4,5-Diacetylrhein; Diacereinum [Latin]; Diacereine [French]; Diacereina [Spanish]; UNII-4HU6J11EL5; Diacerein [INN]; SF-277; C19H12O8; EINECS 237-310-2; BRN 2184909; 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid; MLS000028577; 4HU6J11EL5; 1,8-Diacetoxyanthraquinone-3-carboxylic acid; Diacerein (INN); 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid; NCGC00018274-04; SMR000058958; AK468692

Cross-matching ID

PubChem CID

26248

ChEBI ID

CHEBI:94708

CAS Number

CAS 13739-02-1

TTD Drug ID

DMN2Q5I

General Information of Drug (ID: DMN2Q5I)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[3]
Rilonacept	DMGLUQS	Arthritis	FA20	Approved	[4]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[5]
Canakinumab	DM8HLO5	Autosomal dominant familial periodic fever		Approved	[6]
XOMA 052	DMOKQV7	Type-2 diabetes	5A11	Phase 3	[7]
ABT-981	DM6PTIX	Osteoarthritis	FA00-FA05	Phase 2	[8]
AC-201	DMB0TNL	Type-2 diabetes	5A11	Phase 2	[9]
LY-2189102	DMU81BH	Cardiovascular disease	BA00-BE2Z	Phase 2	[10]
TT-301	DM4QV8Y	Alzheimer disease	8A20	Phase 1	[11]
CYT-013-IL1bQb	DMNICD4	Inflammation	1A00-CA43.1	Phase 1	[12]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[15]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[20]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
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Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[28]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[30]
Indomethacin	DMSC4A7	Bursitis		Approved	[31]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[31]
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Drug(s) Affected By Aggrecan core protein (ACAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[25]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[33]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[36]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[37]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[38]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 beta (IL1B)	TTRYK0X	IL1B_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Gene/Protein Processing	[2]

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29	CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
30	Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
31	Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
32	Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
33	Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
34	Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPAR expression and enhancing Runx2 expression. J Pineal Res. 2010 Nov;49(4):364-72. doi: 10.1111/j.1600-079X.2010.00803.x. Epub 2010 Aug 24.
35	Progesterone induction of chondroitin sulfate proteoglycan aggrecan expression in human endometrial epithelial cells. J Steroid Biochem Mol Biol. 2010 Oct;122(4):159-63. doi: 10.1016/j.jsbmb.2010.07.004. Epub 2010 Jul 29.
36	Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
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38	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.