Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOCID7)

• Drug Name: Etazolate Drug Info
• Synonyms: Etazolate hydrochloride; EHT-0202; SQ-20009

Indication

Disease Entry	ICD 11	Status	REF
Neurodegenerative disorder	8A20-8A23	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 3277
  ChEBI ID: CHEBI:93135
  CAS Number: CAS 51022-77-6
  TTD Drug ID: DMOCID7

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[4]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[5]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[6]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[4]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[7]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[6]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[5]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[6]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[6]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[6]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[15]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[11]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[12]

Drug(s) Affected By Leukotriene C4 synthase (LTC4S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[20]
Pranlukast	DMYHDCA	Allergic rhinitis	CA08.0	Approved	[21]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[3]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
ROLIPRAM	DMJ03UM	Discovery agent	N.A.	Investigative	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-13 (IL13)	OTI4YS3Y	IL13_HUMAN	Gene/Protein Processing	[3]
Leukotriene C4 synthase (LTC4S)	OT3XNFJZ	LTC4S_HUMAN	Protein Interaction/Cellular Processes	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7336).
• [2] Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008 Jul;106(1):392-404.
• [3] Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir Res. 2005 Aug 8;6(1):89. doi: 10.1186/1465-9921-6-89.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [7] Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.
• [8] Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells. J Biochem Mol Toxicol. 2018 Jun;32(6):e22054.
• [9] Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg. 2004 Nov;131(5):585-9. doi: 10.1016/j.otohns.2004.05.028.
• [10] Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
• [11] Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
• [12] Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
• [13] Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide. Chin Med J (Engl). 2008 Nov 20;121(22):2346-9.
• [14] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [15] [Effects of beclomethasone dipropionate and budesonide on interleukin-13 induced cytokine release, proliferation and differentiation of the human lung fibroblasts]. Zhonghua Jie He He Hu Xi Za Zhi. 2007 Aug;30(8):599-604.
• [16] Genetic and ethnic risk factors associated with drug hypersensitivity. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):280-90. doi: 10.1097/ACI.0b013e32833b1eb3.
• [17] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [18] Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene. Eur J Hum Genet. 2003 Aug;11(8):619-22. doi: 10.1038/sj.ejhg.5201015.
• [19] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [20] The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria. J Investig Allergol Clin Immunol. 2009;19(5):375-82.
• [21] Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma. Pharmacogenetics. 2002 Oct;12(7):565-70. doi: 10.1097/00008571-200210000-00009.