Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOJ3CW)

• Drug Name: AGELADINE A Drug Info
• Synonyms: AGELADINE A; CHEMBL230806; CHEBI:65373; 4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine; Ageladine A, TFA; SCHEMBL12563004; BDBM50215926

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10089677
  ChEBI ID: CHEBI:65373
  TTD Drug ID: DMOJ3CW

Molecule-Related Drug Atlas

Drug(s) Targeting Matrix metalloproteinase-12 (MMP-12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Neovastat	DMXTYWJ	Non-small-cell lung cancer	2C25.Y	Phase 1	[3]
FP-025	DMH1NXO	Asthma	CA23	Phase 1	[4]
PMID29130358-Compound-Figure17(12)	DMML4PA	N. A.	N. A.	Patented	[5]
PMID29130358-Compound-Figure17(10)	DMVA15O	N. A.	N. A.	Patented	[5]
PMID29130358-Compound-Figure17(11)	DMSZA9L	N. A.	N. A.	Patented	[5]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[6]
AZD1236	DML3RSF	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 2	[7]
V85546	DMLFMSY	Inflammation	1A00-CA43.1	Discontinued in Phase 1	[8]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[9]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide	DMCNV5J	Discovery agent	N.A.	Investigative	[10]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[19]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[20]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[28]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[34]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[35]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[36]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-12 (MMP-12)	TTXZ0KQ	MMP12_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[2]
Matrix metalloproteinase-14 (MMP14)	OT9C197Z	MMP14_HUMAN	Gene/Protein Processing	[2]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Gene/Protein Processing	[2]

References

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