Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPFLS5)

Drug Name
ABT-100 Drug Info
Synonyms A-367074; A-409100; A-367074.1
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Terminated [1]
Cross-matching ID
PubChem CID
6451154
CAS Number
CAS 450839-40-4
TTD Drug ID
DMPFLS5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting CAAX farnesyltransferase beta (FNTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-745631 DM4UP7R Solid tumour/cancer 2A00-2F9Z Terminated [4]
ABT-839 DM4UN9A Non-small-cell lung cancer 2C25.Y Terminated [5]
MANUMYCIN A DM1SWOY N. A. N. A. Terminated [6]
SCH-44342 DMUL4VX N. A. N. A. Terminated [4]
RPR-113829 DMJ63GW N. A. N. A. Terminated [7]
RPR-114334 DMAIJT6 N. A. N. A. Terminated [7]
L-731735 DM1XBKC Solid tumour/cancer 2A00-2F9Z Terminated [4]
FUSIDIENOL DMI1Y92 N. A. N. A. Terminated [8]
B-956 DM1IO9X Solid tumour/cancer 2A00-2F9Z Terminated [9]
L-739749 DMAUG0L Solid tumour/cancer 2A00-2F9Z Terminated [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTPase HRas (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [10]
Selenium DM25CGV N. A. N. A. Approved [11]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [14]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [16]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [19]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [39]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [11]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [46]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Prednisone DM2HG4X Acute asthma CA23 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Fluoxetine DM3PD2C Bipolar depression Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CAAX farnesyltransferase beta (FNTB) TT7WZIJ FNTB_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Post-Translational Modifications [3]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Post-Translational Modifications [3]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Post-Translational Modifications [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [3]

References

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30 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
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