Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPVNDK)

• Drug Name: Distamycin A Drug Info
• Synonyms: distamycin a; Stallimycin; Distamycin; Herperetin; 636-47-5; DST-A; UNII-80O63P88IS; NSC82150; FI 6426; CHEMBL11252; 80O63P88IS; NCGC00018292-04; NSC 150528; Stallimycinum; Stallimycine; Estalimicina; Stallimicina; Distamicina A; DISTAMYCIN HYDROCHLORIDE; NSC150528; Dst-3; AC1Q5M1Q; AC1L1F7B; DSSTox_RID_81018; DSSTox_CID_25637; DSSTox_GSID_45637; DISTAMYCIN; STALLIMYCIN; SCHEMBL108585; DTXSID9045637; cid_6602691; UPBAOYRENQEPJO-UHFFFAOYSA-N; ZINC3872327; Tox21_110857; 6576-51-8 (mono-hydrochloride); NSC-82150; CCG-36393; BDBM50055659

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3115
  CAS Number: CAS 636-47-5
  TTD Drug ID: DMPVNDK

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid minor groove (hDNA min)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lurbinectedin	DMEFRTZ	Small-cell lung cancer	2C25.Y	Approved	[3]
Brostallicin	DMUI5PA	Breast cancer	2C60-2C65	Phase 2	[4]
Di-imidazole lexitropsin	DME4NH1	Discovery agent	N.A.	Investigative	[5]
Duocarmycin	DM0CQIP	Discovery agent	N.A.	Investigative	[6]
Netropsin	DMOW2QS	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[14]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[16]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[25]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid minor groove (hDNA min)	TTOVXHF	NOUNIPROTAC	Binder (minor groove binder)	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Gene/Protein Processing	[2]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Gene/Protein Processing	[2]
Thymidylate synthase	OTXTG0C7	TYSY_HUMAN	Gene/Protein Processing	[2]

References

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• [2] Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. Amino Acids. 2012 Feb;42(2-3):641-53.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [4] Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity. Expert Opin Investig Drugs. 2009 Dec;18(12):1939-46.
• [5] Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. Structure. 1997 Aug 15;5(8):1033-46.
• [6] Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215.
• [7] Drug-DNA binding specificity: binding of netropsin and distamycin to poly(d2NH2A-dT). Biopolymers. 1990;30(1-2):223-7.
• [8] Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet. 2011 Feb 11;88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007.
• [9] Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics. 2008 Aug 11;1:35. doi: 10.1186/1755-8794-1-35.
• [10] Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity. J Biochem Mol Toxicol. 2015 Mar;29(3):135-9.
• [11] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [12] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [13] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [14] Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
• [15] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [16] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [17] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [18] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [19] Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75.
• [20] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [21] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [22] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [23] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [24] Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
• [25] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.