Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRD1QK)

• Drug Name: Netilmicin Drug Info
• Synonyms: NTL; Netilmicina; Netilmicine; Netilmicinum; Netilyn; Netira; Nettacin; Vectacin; NETILMICIN SULFATE; Sch 20569; Netilmicin (INN); Netilmicin [INN:BAN]; Netilmicina [INN-Spanish]; Netilmicine [INN-French]; Netilmicinum [INN-Latin]; Netira (TN); Nettacin (TN); Sch-20569; O-(2,6-Diamino-2,3,4,6-tetradesoxy-alpha-glycero-4-hexenopyranosyl-(1-4)-O-(3-desoxy-4-C-methyl-3-methylamino-beta-L-arabinopyranosyl-(1-6)-2-desoxy-N1-ethyl-D-streptamin; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; (2R,3S,4S,5S)-2-[(1S,2R,3S,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 1-N-Aethylsisomicin; 1-N-Ethylsisomicin; 2-[4-amino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 4-amino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl 3-deoxy-4-c-methyl-3-(methylamino)pentopyranoside

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 441306
  CAS Number: CAS 56391-56-1
  TTD Drug ID: DMRD1QK
  INTEDE Drug ID: DR1139

Molecule-Related Drug Atlas

Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[5]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[6]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[7]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[8]
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[9]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[10]
Lymecycline	DMOMLHJ	Bacterial infection	1A00-1C4Z	Approved	[11]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[12]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[13]
Minocycline	DMVN5OH	Acne vulgaris	ED80	Approved	[14]

Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[15]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[16]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[17]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[18]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[19]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[20]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[21]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[22]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[23]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[24]

Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[4]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[4]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[4]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[4]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[4]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[4]

Drug(s) Metabolized By Aminoglycoside N-acetyltransferase (aacC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[4]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
RNA cytidine acetyltransferase (hALP)	DEZV4AP	NAT10_HUMAN	Substrate	[3]
Aminoglycoside O-phosphotransferase (aphA6)	DEWPAJD	KKA6_ACIBA	Substrate	[4]
Aminoglycoside N-acetyltransferase (aacC2)	DEJADS9	AAC6_ACIBA	Substrate	[4]

References

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• [4] Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
• [5] The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88.
• [6] Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9.
• [7] Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9.
• [8] Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5.
• [9] Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8.
• [10] Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.
• [11] Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
• [12] Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16.
• [13] Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13.
• [14] Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66.
• [15] Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
• [16] A population and family study of N-acetyltransferase using caffeine urinary metabolites. Clin Pharmacol Ther. 1993 Aug;54(2):134-41.
• [17] Effect of H2-receptor antagonists on rat liver cytosolic acetyl CoA:arylamine N-acetyltransferase activity. Drug Metab Dispos. 1992 Jan-Feb;20(1):74-8.
• [18] Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):862-4.
• [19] Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos. 2005 Jul;33(7):969-76.
• [20] Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.
• [21] NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis. Z Gastroenterol. 2008 Mar;46(3):259-65.
• [22] Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. Eur J Clin Pharmacol. 1999 Jan;54(11):869-76.
• [23] Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5.
• [24] Prizidilol, an antihypertensive with precapillary vasodilator and beta-adrenoceptor blocking actions, in primary hypertension. Clin Pharmacol Ther. 1981 May;29(5):588-93.