Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTQ4PN)

Drug Name
Metastat Drug Info
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Phase 1 [1]
Cross-matching ID
PubChem CID
54678924
CAS Number
CAS 15866-90-7
TTD Drug ID
DMTQ4PN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Matrix metalloproteinase-2 (MMP-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prinomastat DM9HOKG Lung cancer 2C25.0 Approved [6]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [7]
Marimastat DM6V34C Pancreatic cancer 2C10 Phase 3 [8]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [9]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [10]
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [10]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [10]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [10]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [10]
PMID29130358-Compound-Figure18(14) DM7WXJ9 N. A. N. A. Patented [10]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [11]
Gefitinib DM15F0X Colon adenocarcinoma Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Etretinate DM2CZFA Keratosis ED56 Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [17]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [29]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [36]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [37]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [38]
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Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [43]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [44]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
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Drug(s) Affected By Protein kinase C alpha type (PRKCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [54]
Capsaicin DMGMF6V Back pain ME84.Z Approved [55]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [56]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [38]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [62]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [63]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [64]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [67]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [68]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [69]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [72]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [73]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [74]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [75]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [76]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [36]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Meloxicam DM2AR7L Arthritis FA20 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [81]
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Drug(s) Affected By Protein kinase C delta type (PRKCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [83]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [84]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [85]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [86]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [87]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [91]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [92]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [77]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Meloxicam DM2AR7L Arthritis FA20 Approved [95]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [96]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [14]
Selenium DM25CGV N. A. N. A. Approved [62]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [104]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [111]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [4]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [4]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Protein Interaction/Cellular Processes [5]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Protein Interaction/Cellular Processes [5]

References

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12 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
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15 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
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19 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
20 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
21 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
22 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
23 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
24 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
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26 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
27 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
28 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
29 Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
30 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
31 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
32 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
33 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
34 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
35 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
36 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
37 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
38 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
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40 Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
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42 Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
43 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
44 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
45 Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells. Chem Biol Interact. 2023 Nov 1;385:110730. doi: 10.1016/j.cbi.2023.110730. Epub 2023 Oct 7.
46 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
47 Activation of ERK1/2 by protein kinase C-alpha in response to hydrogen peroxide-induced cell death in human gingival fibroblasts. Toxicol In Vitro. 2010 Feb;24(1):319-26. doi: 10.1016/j.tiv.2009.08.007. Epub 2009 Aug 21.
48 Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015 Sep;42(9):1419-29. doi: 10.1007/s11033-015-3921-7. Epub 2015 Aug 27.
49 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
50 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
51 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
52 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
53 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
54 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
55 The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. Cytokine. 2011 Jun;54(3):330-7. doi: 10.1016/j.cyto.2011.03.010. Epub 2011 Apr 6.
56 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
57 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
58 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
59 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
60 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
61 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
62 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
63 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
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