Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUOHVL)

• Drug Name: FLUTROLINE Drug Info
• Synonyms: FLUTROLINE; 70801-02-4; CP-36,584; Flutrolinum; Flutrolino; 2H-Pyrido(4,3-b)indole-2-butanol, 8-fluoro-alpha,5-bis(4-fluorophenyl)-1,3,4,5-tetrahydro-, (+-)-; Flutroline [USAN:INN]; Flutrolinum [INN-Latin]; Flutrolino [INN-Spanish]; 62655-22-5; CP 36,584; AC1L1ALJ; Flutroline (USAN/INN); CHEMBL57241; SCHEMBL121860; OYGDOCFZQVGFIP-UHFFFAOYSA-N; (2-Parafluorophenyl-4-hydroxybutyl)-5-parafluorophenyl-8-fluoro-1,2,3,4-tetrahydro-gamma-carboline

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 51174
  CAS Number: CAS 70801-02-4
  TTD Drug ID: DMUOHVL

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D3 receptor (D3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cariprazine	DMJYDVK	Bipolar disorder	6A60	Approved	[2]
Pramipexole	DMNMW9R	Parkinson disease	8A00.0	Approved	[3]
Ropinirole	DMA6S1D	Parkinson disease	8A00.0	Approved	[3]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]
P2B-001	DM9PVHX	Parkinson disease	8A00.0	Phase 3	[5]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[6]
ONC201	DMM5SCF	Endometrial cancer	2C76	Phase 2	[7]
TAK-906	DMBQD9H	Diabetic gastroparesis	DA41.00	Phase 2	[8]
GSK598809	DMGU05N	Drug abuse	6C4G.1Z	Phase 2	[9]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[9]

Drug(s) Targeting Dopamine D1 receptor (D1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[10]
Pergolide	DM14MAE	Parkinson disease	8A00.0	Approved	[3]
Methylergonovine	DMBEX4O	Spontaneous abortion	JA00.0	Approved	[11]
Fenoldopam	DMFAOKP	Hypertension	BA00-BA04	Approved	[12]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[13]
Ecopipam	DMS9R43	Cocaine addiction	6C45.2	Phase 3	[14]
DAS-431	DMM3BPL	Dementia	6D80-6D86	Phase 2	[15]
Dihydrexidine	DMACPQO	Psychotic disorder	6A20-6A25	Phase 1/2	[16]
Lu AF28996	DMY572G	Parkinson disease	8A00.0	Phase 1	[17]
BAM-1110	DMPMKUF	Parkinson disease	8A00.0	Discontinued in Phase 2	[18]

Drug(s) Targeting Dopamine D4 receptor (D4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[3]
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[10]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[6]
L-745,870	DMTGR25	Psychotic disorder	6A20-6A25	Phase 2	[19]
NGD 94-1	DMM1Y8F	Schizophrenia	6A20	Phase 1	[20]
ABT-724	DMDQVY4	Erectile dysfunction	HA01.1	Discontinued in Phase 2	[21]
Lu-35138	DMQ7A35	Psychotic disorder	6A20-6A25	Discontinued in Phase 2	[22]
NGD-94-4	DMZ9WLO	Schizophrenia	6A20	Discontinued in Phase 1	[23]
PD-165167	DMD0GB4	Schizophrenia	6A20	Preclinical	[20]

Drug(s) Targeting Dopamine D5 receptor (D5R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[10]
LE-300	DMGJL16	Schizophrenia	6A20	Preclinical	[20]
ZD-3638	DM6M9GC	Schizophrenia	6A20	Terminated	[20]
GMC-283	DMT1RH6	Schizophrenia	6A20	Terminated	[20]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[24]
ISOCLOZAPINE	DM52CPU	Discovery agent	N.A.	Investigative	[25]
FLUMEZAPINE	DMW0HOG	Discovery agent	N.A.	Investigative	[26]
ISOLOXAPINE	DMH1BN4	Discovery agent	N.A.	Investigative	[27]
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine	DMOL2Y0	Discovery agent	N.A.	Investigative	[25]
1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine	DMD2NXL	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[28]
Haloperidol	DM96SE0	Delirium		Approved	[29]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[30]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[31]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[32]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[33]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[34]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[35]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[36]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D1 receptor (D1R)	TTZFYLI	DRD1_HUMAN	Inhibitor	[1]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Inhibitor	[1]
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Inhibitor	[1]
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Inhibitor	[1]
Dopamine D5 receptor (D5R)	TTS2PH3	DRD5_HUMAN	Inhibitor	[1]

References

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