Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHIDCJ)

Drug Name
Octreotide Drug Info
Synonyms
Longastatin; Octreotida; Octreotidum; Sandostatine; Octreotida [Spanish]; Octreotide Acetate Salt; Octreotidum [Latin]; DRG-0115; HS-2020; Octreotide-LAR; SAN 201-995; SM 201-995; SMS 201-995; Sandostatin (TN); Sandoz 201-995; Octreotide (USAN/INN); Octreotide [USAN:INN:BAN]; SMS-201-995; Zacycloicosane-4-carboxamide acetate; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide; L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide; 10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa;10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide; 10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Indication
Disease Entry ICD 11 Status REF
Acromegaly 5A60.0 Approved [1]
Carcinoid syndrome 5B10 Approved [2]
Diabetic retinopathy 9B71.0 Approved [2]
Neuroendocrine cancer 2B72.1 Investigative [2]
Therapeutic Class
Anabolic Agents
Cross-matching ID
PubChem CID
448601
CAS Number
CAS 83150-76-9
TTD Drug ID
DMHIDCJ
VARIDT Drug ID
DR01163

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Somatostatin receptor type 2 (SSTR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pasireotide DMHM7JS Cushing disease 5A70 Approved [14]
Lanreotide acetate DMG6ZU4 Acromegaly 5A60.0 Approved [15]
Ga-68-DOTATOC DMZ0P95 Diagnostic imaging N.A. Approved [16]
Copper dotatate Cu-64 DM26KR1 Diagnostic imaging N.A. Approved [17]
ODT-8 DMBWO5T N. A. N. A. Phase 3 [18]
Paltusotine DM97IN2 Acromegaly 5A60.0 Phase 3 [19]
TBR-760 DMM5BVG Pituitary adenoma 2F37.0 Phase 2 [20]
Re-188-P-2045 DM614BA Lung cancer 2C25.0 Phase 1/2 [21]
PEN-221 DMMAUOK Neuroendocrine cancer 2B72.1 Phase 1/2 [22]
FR-121196 DMNRUGA Alzheimer disease 8A20 Terminated [23]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [33]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [34]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [35]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [35]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [36]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [34]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [35]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [34]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [5]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [34]
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Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [42]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [45]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [46]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
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Drug(s) Affected By Thyrotropin subunit beta (TSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [50]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [51]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [52]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [53]
NITRATE DMVFB93 Discovery agent N.A. Investigative [54]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [55]
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Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [61]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [62]
Aripiprazole DM3NUMH Bipolar I disorder Approved [63]
Fluoxetine DM3PD2C Bipolar depression Approved [64]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [65]
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Drug(s) Affected By Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [66]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [67]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [68]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Sodium oxybate DMBOV5P Narcolepsy 7A20 Approved [70]
Ethanol DMDRQZU Chronic pain MG30 Approved [66]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [71]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [72]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [73]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Epinephrine DM3KJBC Acute asthma CA23 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Fructose DM43AN2 Vomiting MD90 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [79]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [80]
Propranolol DM79NTF Angina pectoris BA40 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [86]
Paclitaxel DMLB81S Breast carcinoma Approved [87]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [90]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
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Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [97]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
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Drug(s) Affected By Cholecystokinin (CCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [102]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [103]
Orlistat DMRJSP8 Obesity 5B81 Approved [104]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [106]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [107]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [108]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Epinephrine DM3KJBC Acute asthma CA23 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [115]
Fructose DM43AN2 Vomiting MD90 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [117]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [120]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [86]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [121]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [123]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [125]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [126]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Epinephrine DM3KJBC Acute asthma CA23 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [131]
Fructose DM43AN2 Vomiting MD90 Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [133]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [134]
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Drug(s) Affected By Somatostatin (SST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [137]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [102]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [138]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [110]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [139]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor type 2 (SSTR2) TTZ6T9E SSR2_HUMAN Binder [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [7]
Cholecystokinin (CCK) OT1GCG0L CCKN_HUMAN Protein Interaction/Cellular Processes [8]
Glycoprotein hormones alpha chain (CGA) OT00U3Y3 GLHA_HUMAN Protein Interaction/Cellular Processes [9]
Insulin (INS) OTZ85PDU INS_HUMAN Gene/Protein Processing [10]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Gene/Protein Processing [11]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [12]
Somatostatin (SST) OTY75GQH SMS_HUMAN Protein Interaction/Cellular Processes [6]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Gene/Protein Processing [13]

References

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2 Octreotide FDA Label
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33 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
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44 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
45 Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Endocrinology. 2009 Jun;150(6):2889-97. doi: 10.1210/en.2008-1381. Epub 2009 Feb 19.
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49 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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