General Information of Drug (ID: DMW6GVL)

Drug Name
Nadolol
Synonyms
Anabet; Corgard; Corgaretic; Nadic; Nadololum; Solgol; SQ 11725; SQ11725; Anabet (TN); Corgard (TN); Corzide (TN); Nadololum [INN-Latin]; SQ-11725; Solgol (TN); Alti-Nadolol (TN); Apo-Nadol (TN); Novo-Nadolol (TN); Nadolol (JP15/USP/INN); Nadolol [USAN:BAN:INN:JAN]; (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}oxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol; 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol; 5-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Approved [1]
High blood pressure BA00 Approved [2]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 309.4
Logarithm of the Partition Coefficient (xlogp) 0.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 1021 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 69 +/- 15 mcg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2.7 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [4]
Clearance
The renal clearance of drug is 131-150 mL/min [5]
Elimination
In healthy subjects, following intravenous dosing, 60% of a dose is eliminated in the urine and 15% in the feces after 72 hours [5]
Half-life
The concentration or amount of drug in body reduced by one-half in 20 - 24 hours [6]
Metabolism
The drug is not metabolised [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 34.58205 micromolar/kg/day [7]
Unbound Fraction
The unbound fraction of drug in plasma is 0.14% [8]
Vd
The volume of distribution (Vd) of drug is 147-157 L [5]
Water Solubility
The ability of drug to dissolve in water is measured as 30.4 mg/mL [4]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Adverse drug reaction Not Available CYP2D6 OTZJC802 [9]
Chemical Identifiers
Formula
C17H27NO4
IUPAC Name
(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
Canonical SMILES
CC(C)(C)NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O
InChI
InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1
InChIKey
VWPOSFSPZNDTMJ-UCWKZMIHSA-N
Cross-matching ID
PubChem CID
39147
CAS Number
220045-89-6
DrugBank ID
DB01203
TTD ID
D05SHK
VARIDT ID
DR01261
ACDINA ID
D00452
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Modulator [10]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [11]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Nadolol (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Bepridil DM0RKS4 Moderate Increased risk of cardiac depression by the combination of Nadolol and Bepridil. Angina pectoris [BA40] [13]
Dronedarone DMA8FS5 Moderate Decreased metabolism of Nadolol caused by Dronedarone mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [14]
Cariprazine DMJYDVK Moderate Additive hypotensive effects by the combination of Nadolol and Cariprazine. Bipolar disorder [6A60] [15]
Atracurium DM42HXN Moderate Additive cardiorespiratory depression effects by the combination of Nadolol and Atracurium. Corneal disease [9A76-9A78] [16]
Mivacurium DM473VD Moderate Additive neuromuscular blocking effects by the combination of Nadolol and Mivacurium. Corneal disease [9A76-9A78] [16]
Pasireotide DMHM7JS Moderate Increased risk of atrioventricular block by the combination of Nadolol and Pasireotide. Cushing syndrome [5A70] [17]
OPC-34712 DMHG57U Moderate Additive hypotensive effects by the combination of Nadolol and OPC-34712. Depression [6A70-6A7Z] [15]
Mepenzolate DM8YU2F Moderate Antagonize the effect of Nadolol when combined with Mepenzolate. Digestive system disease [DE2Z] [18]
Levamlodipine DM92S6N Moderate Increased risk of cardiac depression by the combination of Nadolol and Levamlodipine. Hypertension [BA00-BA04] [13]
Clevidipine butyrate DMW4M97 Moderate Increased risk of cardiac depression by the combination of Nadolol and Clevidipine butyrate. Hypertension [BA00-BA04] [13]
Belladonna DM2RBWK Moderate Antagonize the effect of Nadolol when combined with Belladonna. Infectious gastroenteritis/colitis [1A40] [18]
ITI-007 DMUQ1DO Moderate Additive hypotensive effects by the combination of Nadolol and ITI-007. Insomnia [7A00-7A0Z] [15]
Lanthanum carbonate DMMJQSH Moderate Decreased absorption of Nadolol due to formation of complexes caused by Lanthanum carbonate. Mineral absorption/transport disorder [5C64] [17]
Siponimod DM2R86O Major Increased risk of bradycardia by the combination of Nadolol and Siponimod. Multiple sclerosis [8A40] [19]
Fingolimod DM5JVAN Major Increased risk of bradycardia by the combination of Nadolol and Fingolimod. Multiple sclerosis [8A40] [20]
Ozanimod DMT6AM2 Moderate Increased risk of bradycardia by the combination of Nadolol and Ozanimod. Multiple sclerosis [8A40] [21]
Polythiazide DMCH80F Moderate Increased risk of ventricular arrhythmias by the combination of Nadolol and Polythiazide. Oedema [MG29] [22]
Methylscopolamine DM5VWOB Moderate Antagonize the effect of Nadolol when combined with Methylscopolamine. Peptic ulcer [DA61] [18]
Silodosin DMJSBT6 Moderate Additive hypotensive effects by the combination of Nadolol and Silodosin. Prostate hyperplasia [GA90] [23]
Levomepromazine DMIKFEL Moderate Additive hypotensive effects by the combination of Nadolol and Levomepromazine. Psychotic disorder [6A20-6A25] [15]
Quetiapine DM1N62C Moderate Additive hypotensive effects by the combination of Nadolol and Quetiapine. Schizophrenia [6A20] [15]
Aripiprazole DM3NUMH Moderate Additive hypotensive effects by the combination of Nadolol and Aripiprazole. Schizophrenia [6A20] [15]
Iloperidone DM6AUFY Moderate Additive hypotensive effects by the combination of Nadolol and Iloperidone. Schizophrenia [6A20] [15]
Paliperidone DM7NPJS Moderate Additive hypotensive effects by the combination of Nadolol and Paliperidone. Schizophrenia [6A20] [15]
Molindone DMAH70G Moderate Additive hypotensive effects by the combination of Nadolol and Molindone. Schizophrenia [6A20] [15]
Thiothixene DMDINC4 Moderate Additive hypotensive effects by the combination of Nadolol and Thiothixene. Schizophrenia [6A20] [15]
Asenapine DMSQZE2 Moderate Additive hypotensive effects by the combination of Nadolol and Asenapine. Schizophrenia [6A20] [15]
Pipecuronium DM5F84A Moderate Additive cardiorespiratory depression effects by the combination of Nadolol and Pipecuronium. Tonus and reflex abnormality [MB47] [16]
Vecuronium DMP0UK2 Moderate Additive neuromuscular blocking effects by the combination of Nadolol and Vecuronium. Tonus and reflex abnormality [MB47] [16]
Trimeprazine DMEMV9D Moderate Additive hypotensive effects by the combination of Nadolol and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [24]
⏷ Show the Full List of 30 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 2 E00446 2723854 Colorant
Kyselina citronova E00014 311 Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Carmellose sodium E00625 Not Available Disintegrant
Citric acid monohydrate E00271 22230 Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Vinylpyrrolidone E00668 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Water E00035 962 Solvent
⏷ Show the Full List of 14 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Nadolol 80 mg tablet 80 mg Oral Tablet Oral
Nadolol 20 mg tablet 20 mg Oral Tablet Oral
Nadolol 40 mg tablet 40 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Nadolol FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 554).
3 Schafer-Korting M, Bach N, Knauf H, Mutschler E: Pharmacokinetics of nadolol in healthy subjects. Eur J Clin Pharmacol. 1984;26(1):125-7.
4 BDDCS applied to over 900 drugs
5 Kohne CH, Peters GJ: UFT: mechanism of drug action. Oncology (Williston Park). 2000 Oct;14(10 Suppl 9):13-8.
6 FDA Approved Drug Products: Nadolol Oral Tablets
7 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
8 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
11 Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39.
12 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
13 Anastassiades CJ "Nifedipine and beta-blocker drugs." Br Med J 281 (1980): 1251-2. [PMID: 6107167]
14 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
15 Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
16 Chapple DJ, Clark JS, Hughes R "Interaction between atracurium and drugs used in anaesthesia." Br J Anaesth 55 Suppl 1 (1983): s17-22. [PMID: 6688011]
17 Canadian Pharmacists Association.
18 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
19 Cerner Multum, Inc. "Australian Product Information.".
20 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
21 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
22 Dean S, Kendall MJ, Potter S, Thompson MH, Jackson DA "Nadolol in combination with indapamide and xipamide in resistant hypertensives." Eur J Clin Pharmacol 28 (1985): 29-33. [PMID: 3987783]
23 Chrysant SG "Experience with terazosin administered in combination with other antihypertensive agents." Am J Med 80 (1986): 55-61. [PMID: 2872808]
24 Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.