Details of Disease

Disease Name

Hashimoto thyroiditis

HT; Hashimotos syndrome; Hashimoto thyroiditides; hypothyroidism, autoimmune; Hashimoto's syndromes; thyroiditides, chronic lymphocytic; hypothyroidism, autoimmune thyroid autoantibodies, included; disease, Hashimoto's; lymphocytic thyroiditides, chronic; syndrome, Hashimoto's; Ht; Hashimotos disease; Hashimoto's struma; thyroiditis, chronic lymphocytic; syndromes, Hashimoto's; thyroid autoantibodies; Hashimoto struma; thyroiditides, Hashimoto; thyroiditis, Hashimoto; Hashimoto syndrome; autoimmune thyroiditis; disease, Hashimoto; chronic lymphocytic thyroiditides; lymphocytic thyroiditis, chronic; lymphocytic thyroiditis; Hashimoto disease; chronic lymphocytic thyroiditis; Hashimoto's disease; Hashimoto's thyroiditis; Hashimoto's syndrome; Hashimoto hypothyroidism; Hashimoto thyroiditis

Definition

An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. There is progressive destruction of the thyroid follicles leading to hypothyroidism.

Disease Hierarchy

DISYKSRF: Genetic disease

DISIHC6A: Autoimmune thyroid disease

DIS77CDF: Hashimoto thyroiditis

Disease Identifiers

MONDO ID

MONDO_0007699

MESH ID

D050031

UMLS CUI

C0677607

OMIM ID

140300

MedGen ID

151769

HPO ID

HP:0000872

Orphanet ID

855

SNOMED CT ID

21983002

General Information of Disease (ID: DIS77CDF)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Levothyroxine	DMHN027	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 37 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BLK	TTNDSC3	Limited	Genetic Variation	[2]
IKZF2	TTKT5NV	Limited	Biomarker	[3]
IKZF3	TTCZVFZ	Limited	Genetic Variation	[4]
IL2RA	TT10Y9E	Limited	Biomarker	[5]
KIR2DL2	TTU0P73	Limited	Biomarker	[6]
KIR2DS2	TTV3CFI	Limited	Biomarker	[6]
TIGIT	TTWNL74	Limited	Altered Expression	[3]
CD1A	TTBGTFN	moderate	Altered Expression	[7]
CD3G	TTV3XPL	moderate	Biomarker	[8]
CD83	TTT9MRQ	moderate	Altered Expression	[9]
IFNL1	TTM624L	moderate	Genetic Variation	[10]
IL18RAP	TTZUJVE	moderate	Genetic Variation	[11]
IL21R	TTZO9B0	moderate	Altered Expression	[12]
NCOA4	TT8OY02	moderate	Biomarker	[13]
PTGDR2	TTQDMX5	moderate	Altered Expression	[14]
TK1	TTP3QRF	moderate	Biomarker	[15]
TNFRSF25	TTDV6BQ	moderate	Genetic Variation	[16]
TPH2	TT3KLDP	moderate	Genetic Variation	[17]
AQP3	TTLDNMQ	Strong	Genetic Variation	[18]
C1S	TT7LRQH	Strong	Biomarker	[19]
F9	TTFEZ5Q	Strong	Genetic Variation	[20]
FCGRT	TTKLPHO	Strong	Altered Expression	[21]
ICOS	TTE5VP6	Strong	Biomarker	[22]
IL12B	TTGW72V	Strong	Genetic Variation	[18]
IL17F	TT2B6PS	Strong	Genetic Variation	[23]
IL1RL1	TT4GZA4	Strong	Biomarker	[24]
IL23A	TTC1GLB	Strong	Altered Expression	[25]
IL23R	TT6H4QR	Strong	Altered Expression	[26]
KRT19	TT3JF9E	Strong	Biomarker	[27]
RET	TT4DXQT	Strong	Genetic Variation	[28]
SLC26A4	TT7X02I	Strong	Altered Expression	[29]
SLC6A4	TT3ROYC	Strong	Genetic Variation	[30]
TNFSF4	TTBW580	Strong	Biomarker	[31]
TSHR	TT6NYJA	Strong	Biomarker	[32]
FOXP3	TT1X3QF	Definitive	Biomarker	[33]
RARG	TT1Q3IE	Definitive	Altered Expression	[34]
VDR	TTK59TV	Definitive	Genetic Variation	[35]
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⏷ Show the Full List of 37 DTT(s)

This Disease Is Related to 4 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCC11	DTWN7FC	Limited	Altered Expression	[36]
SLC5A8	DTE3TAW	Limited	Biomarker	[37]
SLC22A4	DT2EG60	moderate	Genetic Variation	[38]
SLC25A27	DT0HW5C	Strong	Genetic Variation	[39]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP27B1	DE3FYEM	Strong	Genetic Variation	[40]
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This Disease Is Related to 49 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CEP128	OT922YCJ	Limited	Genetic Variation	[41]
DIO2	OTGPNSLH	Limited	Genetic Variation	[42]
EOMES	OTB9VQFA	Limited	Altered Expression	[43]
GNA14	OTYZ1ZI0	Limited	Genetic Variation	[44]
IP6K3	OTKUIVQZ	Limited	Genetic Variation	[44]
IRAK2	OT6Y1QZN	Limited	Genetic Variation	[45]
MAGI2	OTXDDKZS	Limited	Genetic Variation	[46]
MBIP	OTORHZ9Y	Limited	Genetic Variation	[47]
NUDT1	OTZSES3W	Limited	Biomarker	[48]
RAB4A	OT7BL9WW	Limited	Biomarker	[49]
SCGB3A2	OTB63PHR	Limited	Altered Expression	[50]
SDK2	OTTBK3MH	Limited	Genetic Variation	[44]
SLAMF1	OTBTT3ZQ	Limited	Biomarker	[51]
TLR10	OTQ1KVJO	Limited	Genetic Variation	[45]
BANK1	OTXAAA11	moderate	Genetic Variation	[52]
CD1C	OT4XINUJ	moderate	Altered Expression	[7]
DOCK11	OTFSTN6A	moderate	Genetic Variation	[53]
EARS2	OTNCJKY7	moderate	Genetic Variation	[54]
ECD	OT3L3PCU	moderate	Biomarker	[55]
FBN3	OTEWLXTH	moderate	Biomarker	[56]
FCRL1	OTXOYT29	moderate	Altered Expression	[57]
FCRL2	OT0RLDOD	moderate	Altered Expression	[57]
FCRLA	OT6MK4M1	moderate	Altered Expression	[57]
NDUFB2	OT4717TF	moderate	Biomarker	[58]
RASGRP1	OTX9WN2E	moderate	Genetic Variation	[59]
TNFSF18	OT3ANRX1	moderate	Biomarker	[60]
TNFSF8	OTDYGDJ3	moderate	Altered Expression	[61]
ATN1	OTNZFLKY	Strong	Biomarker	[62]
BACH2	OT17GS18	Strong	Genetic Variation	[63]
CA10	OTC3N1F6	Strong	Genetic Variation	[64]
CCDC6	OTXRQDYG	Strong	Genetic Variation	[20]
CLDN1	OT27KV99	Strong	Altered Expression	[65]
FCRL3	OTIFXFWL	Strong	Altered Expression	[3]
FLNB	OTPCOYL6	Strong	Biomarker	[66]
FOXD3	OTXYV6GO	Strong	Altered Expression	[67]
H2AC14	OT5Y4MMC	Strong	Biomarker	[68]
HLA-C	OTV38BUJ	Strong	Altered Expression	[69]
HLA-DPB1	OTW8JHU2	Strong	Biomarker	[70]
HLA-DRB4	OTNXIHQU	Strong	Biomarker	[71]
IFIH1	OTZA2AHA	Strong	Genetic Variation	[72]
LPP	OT6TU8SE	Strong	Genetic Variation	[63]
RBM45	OTWTHD77	Strong	Biomarker	[73]
SELENOS	OTUEWIU9	Strong	Biomarker	[74]
TAS2R38	OTX5MM36	Strong	Genetic Variation	[20]
TIMM23	OTAAS85T	Strong	Genetic Variation	[64]
TRIM60	OT6FH4DN	Strong	Genetic Variation	[64]
TSHB	OTFDI39D	Strong	Altered Expression	[75]
C6orf47	OTMKBNDD	Definitive	Genetic Variation	[76]
ISG20	OTCWRJJW	Definitive	Biomarker	[5]
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⏷ Show the Full List of 49 DOT(s)

References

1	Levothyroxine FDA Label
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3	Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis.Exp Clin Endocrinol Diabetes. 2019 May;127(5):281-288. doi: 10.1055/a-0597-8948. Epub 2018 Jun 11.
4	Polymorphisms of IKZF3 Gene and Autoimmune Thyroid Diseases: Associated with Graves' Disease but Not with Hashimoto's Thyroiditis.Cell Physiol Biochem. 2018;45(5):1787-1796. doi: 10.1159/000487870. Epub 2018 Feb 28.
5	Novel missense mutation in PTPN22 in a Chinese pedigree with Hashimoto's thyroiditis.BMC Endocr Disord. 2018 Nov 1;18(1):76. doi: 10.1186/s12902-018-0305-8.
6	KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR GENES AND THEIR HLA-C LIGANDS IN HASHIMOTO THYROIDITIS IN A CHINESE POPULATION.Endocr Pract. 2016 Aug;22(8):935-40. doi: 10.4158/EP151175.OR. Epub 2016 Apr 4.
7	CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis.J Immunol. 2005 Mar 15;174(6):3773-80. doi: 10.4049/jimmunol.174.6.3773.
8	CD3G gene defects in familial autoimmune thyroiditis.Scand J Immunol. 2014 Nov;80(5):354-61. doi: 10.1111/sji.12200.
9	The expression and distribution of S-100 protein and CD 83 in thyroid tissues of autoimmune thyroid diseases.Cell Mol Immunol. 2004 Oct;1(5):378-82.
10	Increased Serum Levels of IL-28 and IL-29 and the Protective Effect of IL28B rs8099917 Polymorphism in Patients with Hashimoto's Thyroiditis.Immunol Invest. 2016 Oct;45(7):668-78. doi: 10.1080/08820139.2016.1208215. Epub 2016 Sep 12.
11	Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.Int J Immunogenet. 2016 Feb;43(1):18-24. doi: 10.1111/iji.12240. Epub 2015 Nov 14.
12	Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease.Cytokine. 2015 Apr;72(2):160-5. doi: 10.1016/j.cyto.2014.11.005. Epub 2015 Jan 31.
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14	CXCR3, CCR5, and CRTH2 Chemokine Receptor Expression in Lymphocytes Infiltrating Thyroid Nodules with Coincident Hashimoto's Thyroiditis Obtained by Fine Needle Aspiration Biopsy.J Immunol Res. 2016;2016:2743614. doi: 10.1155/2016/2743614. Epub 2016 Oct 31.
15	Expression of genes for certain enzymes of pyrimidine and purine salvage pathway in peripheral blood leukocytes collected from patients with Graves' or Hashimoto's disease.J Cell Biochem. 2003 Jun 1;89(3):550-5. doi: 10.1002/jcb.10533.
16	HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene.J Exp Med. 1996 Sep 1;184(3):1167-72. doi: 10.1084/jem.184.3.1167.
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18	IL-12B and IL-10 gene polymorphisms in the development of Hashimoto's thyroiditis.Int J Immunogenet. 2016 Dec;43(6):397-403. doi: 10.1111/iji.12293. Epub 2016 Oct 24.
19	Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases. J Immunol. 2001 Jun 15;166(12):7612-6. doi: 10.4049/jimmunol.166.12.7612.
20	Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto's Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis.Onco Targets Ther. 2019 Oct 14;12:8479-8489. doi: 10.2147/OTT.S226426. eCollection 2019.
21	Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses.Mol Cell Endocrinol. 2018 Dec 5;477:103-111. doi: 10.1016/j.mce.2018.06.006. Epub 2018 Jun 14.
22	Increased circulating follicular regulatory T cells in Hashimoto's thyroiditis.Autoimmunity. 2018 Nov;51(7):345-351. doi: 10.1080/08916934.2018.1516759. Epub 2018 Oct 20.
23	Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease.Autoimmunity. 2018 Nov;51(7):360-369. doi: 10.1080/08916934.2018.1534963. Epub 2018 Nov 24.
24	Dysregulated Interleukin -33/ST2 Pathway Perpetuates Chronic Inflammation in Hashimoto's Thyroiditis.Endocr Metab Immune Disord Drug Targets. 2019;19(7):1012-1021. doi: 10.2174/1871530319666190226164309.
25	Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1 in Hashimoto's thyroiditis but not in Graves' disease.Endocr J. 2019 May 28;66(5):423-430. doi: 10.1507/endocrj.EJ18-0396. Epub 2019 Mar 27.
26	Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto's thyroiditis.Immunol Res. 2015 Jun;62(2):129-36. doi: 10.1007/s12026-015-8643-3.
27	Indicators of multifocality in papillary thyroid carcinoma concurrent with Hashimoto's thyroiditis.Am J Cancer Res. 2019 Aug 1;9(8):1786-1795. eCollection 2019.
28	Solid papillary thyroid carcinoma with Hashimoto's thyroiditis: description of a further case with challenging cytological features.BMJ Case Rep. 2019 Jan 17;12(1):e226153. doi: 10.1136/bcr-2018-226153.
29	Screening of SLC26A4 gene in autoimmune thyroid diseases.Int J Immunogenet. 2013 Aug;40(4):284-91. doi: 10.1111/iji.12035. Epub 2012 Dec 22.
30	The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action.ACS Chem Neurosci. 2019 Jul 17;10(7):3053-3060. doi: 10.1021/acschemneuro.9b00005. Epub 2019 Mar 13.
31	OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-B Signaling.J Immunol. 2019 Dec 15;203(12):3225-3236. doi: 10.4049/jimmunol.1900530. Epub 2019 Nov 8.
32	Bipolar limbic expression of auto-immune thyroid targets: thyroglobulin and thyroid-stimulating hormone receptor.Metab Brain Dis. 2019 Oct;34(5):1281-1298. doi: 10.1007/s11011-019-00437-w. Epub 2019 Jun 13.
33	The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis.Endocr J. 2020 Mar 28;67(3):317-326. doi: 10.1507/endocrj.EJ19-0307. Epub 2019 Dec 10.
34	Causal associations of autoimmune thyroiditis and papillary thyroid carcinoma: mRNA expression of selected nuclear receptors and other molecular targets.Oncol Lett. 2019 Oct;18(4):4270-4277. doi: 10.3892/ol.2019.10770. Epub 2019 Aug 22.
35	Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?.Biomed Res Int. 2019 Aug 21;2019:8197580. doi: 10.1155/2019/8197580. eCollection 2019.
36	Myeloid related proteins are up-regulated in autoimmune thyroid diseases and activate toll-like receptor 4 and pro-inflammatory cytokines in vitro.Int Immunopharmacol. 2018 Jun;59:217-226. doi: 10.1016/j.intimp.2018.04.009. Epub 2018 Apr 13.
37	The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus.Microvasc Res. 2019 May;123:68-73. doi: 10.1016/j.mvr.2019.01.002. Epub 2019 Jan 3.
38	Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population.BMC Med Genet. 2015 Sep 2;16:76. doi: 10.1186/s12881-015-0222-x.
39	Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.J Clin Endocrinol Metab. 2015 Feb;100(2):E319-24. doi: 10.1210/jc.2014-3431. Epub 2014 Nov 27.
40	A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans.Eur J Endocrinol. 2004 Aug;151(2):193-7. doi: 10.1530/eje.0.1510193.
41	CEP128 is a crucial risk locus for autoimmune thyroid diseases.Mol Cell Endocrinol. 2019 Jan 15;480:97-106. doi: 10.1016/j.mce.2018.10.017. Epub 2018 Oct 27.
42	Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases.Immunol Invest. 2018 Jul;47(5):534-542. doi: 10.1080/08820139.2018.1458861. Epub 2018 Apr 12.
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44	Genome-wide association analysis suggests novel loci for Hashimoto's thyroiditis.J Endocrinol Invest. 2019 May;42(5):567-576. doi: 10.1007/s40618-018-0955-4. Epub 2018 Oct 3.
45	IRAK2 and TLR10 confer risk of Hashimoto's disease: a genetic association study based on the Han Chinese population.J Hum Genet. 2019 Jul;64(7):617-623. doi: 10.1038/s10038-019-0613-5. Epub 2019 May 9.
46	The MAGI2 gene polymorphism rs2160322 is associated with Graves' disease but not with Hashimoto's thyroiditis.J Endocrinol Invest. 2019 Jul;42(7):843-850. doi: 10.1007/s40618-018-0990-1. Epub 2018 Dec 8.
47	Association of Established Thyroid-stimulating Hormone and Free Thyroxine Genetic Variants with Hashimoto's Thyroiditis.Immunol Invest. 2017 Aug;46(6):625-638. doi: 10.1080/08820139.2017.1337785.
48	High iodine induces DNA damage in autoimmune thyroiditis partially by inhibiting the DNA repair protein MTH1.Cell Immunol. 2019 Oct;344:103948. doi: 10.1016/j.cellimm.2019.103948. Epub 2019 Jul 2.
49	Serotonin improves glucose metabolism by Serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells.Diabetol Metab Syndr. 2017 Jan 3;9:1. doi: 10.1186/s13098-016-0201-1. eCollection 2017.
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51	Expression and Function of the Costimulatory Receptor SLAMF1 Is Altered in Lymphocytes From Patients With Autoimmune Thyroiditis.J Clin Endocrinol Metab. 2017 Feb 1;102(2):672-680. doi: 10.1210/jc.2016-2322.
52	Genetic variants of BANK1 gene in autoimmune thyroid diseases: a case-control association study.Exp Clin Endocrinol Diabetes. 2013 Oct;121(9):556-60. doi: 10.1055/s-0033-1348220. Epub 2013 Oct 14.
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57	Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.Horm Metab Res. 2015 Aug;47(9):693-8. doi: 10.1055/s-0035-1545280. Epub 2015 Mar 4.
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59	Association of established thyroid peroxidase autoantibody (TPOAb) genetic variants with Hashimoto's thyroiditis.Autoimmunity. 2016 Nov;49(7):480-485. doi: 10.1080/08916934.2016.1191475. Epub 2016 Jun 7.
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61	Immunoexpression of the CD30 ligand/CD30 and IL-6/IL-6R signals in thyroid autoimmune diseases.Histol Histopathol. 2006 Mar;21(3):249-56. doi: 10.14670/HH-21.249.
62	To reflect human autoimmune thyroiditis, thyroid peroxidase (not thyroglobulin) antibodies should be measured in female (not sex-independent) NOD.H2(h4) mice.Clin Exp Immunol. 2019 Apr;196(1):52-58. doi: 10.1111/cei.13249. Epub 2019 Jan 11.
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65	Heterogeneity of tissue IL-17 and tight junction proteins expression demonstrated in patients with autoimmune thyroid diseases.Medicine (Baltimore). 2018 Jun;97(25):e11211. doi: 10.1097/MD.0000000000011211.
66	Association of the TGrI29 microsatellite in thyroglobulin gene with autoimmune thyroiditis in a Argentinian population: a case-control study.Endocrine. 2010 Dec;38(3):320-7. doi: 10.1007/s12020-010-9398-1. Epub 2010 Oct 23.
67	A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies.J Clin Endocrinol Metab. 2015 Oct;100(10):E1335-42. doi: 10.1210/jc.2015-2126. Epub 2015 Aug 12.
68	A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes.Cell Immunol. 2008 Jan;251(1):1-7. doi: 10.1016/j.cellimm.2008.02.002. Epub 2008 Apr 14.
69	Circulating Exosomes Activate Dendritic Cells and Induce Unbalanced CD4+ T Cell Differentiation in Hashimoto Thyroiditis.J Clin Endocrinol Metab. 2019 Oct 1;104(10):4607-4618. doi: 10.1210/jc.2019-00273.
70	Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With DPB1*0201: Data From the Type 1 Diabetes Genetics Consortium.Diabetes Care. 2015 Oct;38 Suppl 2(Suppl 2):S21-8. doi: 10.2337/dcs15-2005.
71	Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis.J Clin Endocrinol Metab. 2014 Feb;99(2):E379-83. doi: 10.1210/jc.2013-2841. Epub 2013 Nov 27.
72	Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.Autoimmunity. 2018 Jun;51(4):183-190. doi: 10.1080/08916934.2018.1486824. Epub 2018 Jul 4.
73	Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease.Gene. 2018 Feb 5;642:430-438. doi: 10.1016/j.gene.2017.11.057. Epub 2017 Nov 22.
74	Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis.Thyroid. 2017 May;27(5):597-610. doi: 10.1089/thy.2016.0635. Epub 2017 Apr 6.
75	Functional human TSH splice variant produced by plasma cell may be involved in the immunologic injury of thyroid in the patient with Hashimoto's thyroiditis.Mol Cell Endocrinol. 2015 Oct 15;414:132-42. doi: 10.1016/j.mce.2015.06.009. Epub 2015 Jul 11.
76	Diagnostic significance of CK19, galectin-3, CD56, TPO and Ki67 expression and BRAF mutation in papillary thyroid carcinoma.Oncol Lett. 2018 Apr;15(4):4269-4277. doi: 10.3892/ol.2018.7873. Epub 2018 Jan 26.