Details of Disease

General Information of Disease (ID: DISOKJWA)

Disease Name Lupus
Synonyms lupus; lupus erythematosus
Disease Class 4A40: Lupus erythematosus
Definition
An autoimmune, connective tissue chronic inflammatory disorder affecting the skin, joints, kidneys, lungs, heart, and the peripheral blood cells. It is more commonly seen in women than men. Variants include discoid and systemic lupus erythematosus.
Disease Hierarchy
DISORMTM: Autoimmune disease
DIS77ACK: Rheumatic disorder
DISOKJWA: Lupus
ICD Code
ICD-11
ICD-11: 4A40
ICD-9
ICD-9: 710
Expand ICD-11
'4A40
Expand ICD-10
'L80-L99; 'L93; 'L93.2
Expand ICD-9
710
Disease Identifiers
MONDO ID
MONDO_0004670
UMLS CUI
C0409974
MedGen ID
98043
SNOMED CT ID
200936003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Abrocitinib DM8J29L Approved NA [1]
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This Disease is Treated as An Indication in 9 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Atacicept DM8GFEV Phase 3 NA [2]
BVT.2733 DM6RUKX Phase 3 Small molecular drug [3]
Laquinimod DM3IWS8 Phase 3 Small molecular drug [4]
OMS721 DMK6QBZ Phase 3 NA [3]
ANTI-TWEAK DMQH2TQ Phase 2 NA [5]
BI 655064 DMF86P2 Phase 2 Antibody [3]
Paquinimod DMPO4M1 Phase 2 Small molecular drug [6]
PF-06823859 DM8C1H4 Phase 2 NA [3]
PF-06650833 DMJAXTY Phase 1 NA [7]
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⏷ Show the Full List of 9 Drug(s)
This Disease is Treated as An Indication in 2 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Abetimus sodium DMAENDF Discontinued in Phase 3 NA [8]
PMI-001 DMDZBIQ Discontinued in Phase 3 NA [9]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Y-175L DM97ZTT Investigative NA [10]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 81 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
BLK TTNDSC3 Limited Genetic Variation [11]
CD28 TTQ13FT Limited Altered Expression [12]
IL22 TTLDX4N Limited Biomarker [13]
KIR2DS1 TTVWAGF Limited Biomarker [14]
TLR5 TTCXP8J Limited Biomarker [15]
TNFSF12 TTBTDM1 Limited Altered Expression [16]
TP53BP1 TTX4UE9 Limited Genetic Variation [17]
APOH TT2OUI9 moderate Biomarker [18]
CD40LG TTIJP3Q moderate Altered Expression [19]
CD52 TTQT5S9 moderate Biomarker [20]
CR2 TT0HUN7 moderate Biomarker [21]
CYBB TT5T8MR moderate Biomarker [22]
EPHX2 TT7WVHI moderate Biomarker [23]
FCGR2A TTXT21W moderate Biomarker [24]
FCGR2B TT5RWKQ moderate Biomarker [25]
FCGR3A TTIFOC0 moderate Biomarker [26]
IL17A TTG0MT6 moderate Altered Expression [27]
IRAK1 TTXAJWN moderate Biomarker [28]
ITGB2 TTIJWR7 moderate Genetic Variation [29]
KLK4 TT4319X moderate Genetic Variation [30]
PLA2R1 TTHKW7D moderate Biomarker [31]
SDC2 TT5H2F0 moderate Biomarker [32]
TLR9 TTSHG0T moderate Biomarker [33]
TRIM27 TTTO3QN moderate Biomarker [34]
ABHD6 TTSINOV Strong Biomarker [35]
ADAM10 TTVXEGU Strong Biomarker [36]
APOL1 TTDB8PW Strong Biomarker [37]
BST2 TT90BJT Strong Genetic Variation [38]
BTK TTGM6VW Strong Biomarker [39]
BTLA TTER58P Strong Biomarker [40]
CALR TTUZ7OA Strong Biomarker [41]
CAMP TTULOB6 Strong Biomarker [42]
CASP6 TTKW4ML Strong Biomarker [43]
CD2 TTJDUNO Strong Genetic Variation [44]
CD69 TTPQE9F Strong Altered Expression [45]
CD70 TTNCIE0 Strong Altered Expression [46]
CSF3R TTC70AJ Strong Biomarker [47]
CXCL13 TT0NIZ1 Strong Biomarker [48]
CXCR5 TTIW59R Strong Biomarker [49]
DGAT1 TT0GV3R Strong Biomarker [50]
F12 TTRJSMV Strong Genetic Variation [51]
FCER1G TTDGEC0 Strong Altered Expression [52]
GEM TTAZF9M Strong Altered Expression [12]
HDAC6 TT5ZKDI Strong Biomarker [53]
ICOS TTE5VP6 Strong Biomarker [36]
IFNAR1 TTSYFMA Strong Biomarker [54]
IFNAR2 TTMQB37 Strong Biomarker [55]
IL21 TT9QEJ6 Strong Biomarker [56]
IL21R TTZO9B0 Strong Biomarker [57]
IL3RA TTENHJ0 Strong Biomarker [58]
IRAK4 TTILUKB Strong Altered Expression [59]
ITGAE TTH0Z37 Strong Biomarker [60]
ITGAL TT48WR6 Strong Altered Expression [12]
ITGAM TTB69FJ Strong Genetic Variation [29]
KIF5A TTCJPAH Strong Biomarker [61]
KIR3DL2 TTQH3N0 Strong Biomarker [62]
LCT TTA0OSE Strong Biomarker [63]
LILRB4 TTREOKA Strong Genetic Variation [64]
MBL2 TTMQDZ5 Strong Biomarker [65]
MFGE8 TT1GLAJ Strong Biomarker [66]
PADI4 TTQHAXM Strong Biomarker [67]
PDE7A TT1BC3A Strong Biomarker [68]
PDE8A TTIS4OW Strong Genetic Variation [69]
RIPK4 TTB4S01 Strong Biomarker [70]
RSPO1 TTI9HL4 Strong Altered Expression [71]
SERPINB3 TT6QLPX Strong Biomarker [72]
SLAMF6 TTSIYJ6 Strong Altered Expression [73]
SLC38A1 TT1YE9Z Strong Biomarker [74]
SUV39H1 TTUWQTK Strong Altered Expression [75]
TAGLN2 TTP6BIJ Strong Altered Expression [76]
TBX21 TTNF9PH Strong Altered Expression [77]
TGFB3 TTWOMY8 Strong Biomarker [78]
TIGIT TTWNL74 Strong Genetic Variation [79]
TNFRSF13B TTL9OD4 Strong Biomarker [80]
TNFRSF17 TTZ3P4W Strong Biomarker [81]
TNFSF13 TTOI1RM Strong Biomarker [82]
TNFSF13B TTWMIDN Strong Biomarker [83]
TNFSF4 TTBW580 Strong Genetic Variation [84]
TREM1 TTHZQP0 Strong Biomarker [85]
TRPM2 TTEBMN7 Strong Biomarker [86]
VSIR TT51SK8 Strong Biomarker [87]
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⏷ Show the Full List of 81 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCD1 DTKM9DZ Strong Biomarker [88]
SLC4A1 DTB0Q3P Strong Altered Expression [89]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ACP5 DESITDW Strong Genetic Variation [90]
AKR1C4 DEAJN47 Strong Biomarker [91]
UBASH3B DE10BJ5 Strong Biomarker [92]
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This Disease Is Related to 117 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
FLI1 OT0EV3LX Limited Biomarker [93]
LGALS9 OT7MF91K Limited Biomarker [94]
TRIM21 OTA4UJCF Limited Biomarker [95]
ADD2 OTRCPCD2 moderate Genetic Variation [96]
BCR OTCN76C1 moderate Altered Expression [42]
CAMK4 OT47RDGV moderate Altered Expression [97]
CCL3L1 OTQXCYB1 moderate Genetic Variation [98]
IFI16 OT4SPU0U moderate Biomarker [99]
IFNA1 OTPMKY0L moderate Biomarker [100]
MACROH2A1 OTV2DQDD moderate Genetic Variation [101]
RFX1 OTZUDMPR moderate Biomarker [102]
RNPC3 OTW5MKC1 moderate Biomarker [103]
AFF1 OTT2C78E Strong Genetic Variation [104]
AIM2 OT86QUI8 Strong Genetic Variation [17]
ANP32B OT3SQMLU Strong Biomarker [82]
ANXA6 OT9KIQ0Y Strong Biomarker [92]
APOM OTI3FQQC Strong Altered Expression [105]
ARID3A OTZZ4SFP Strong Altered Expression [106]
ATG12 OTJRO09Y Strong Altered Expression [88]
BANK1 OTXAAA11 Strong Genetic Variation [11]
BDH2 OTDD7G8S Strong Altered Expression [107]
BTG3 OT9ANHVT Strong Biomarker [108]
C1QC OTLE5U1P Strong Biomarker [109]
C1QL1 OTNQ0G3E Strong Genetic Variation [110]
C1R OTA0ZNIU Strong Genetic Variation [111]
C2 OTHMF4YM Strong Biomarker [112]
CBLIF OTNE20WU Strong Altered Expression [113]
CD180 OTITK5E6 Strong Biomarker [114]
CD244 OTSMR85N Strong Biomarker [115]
CD48 OT83ZNPP Strong Genetic Variation [116]
CD72 OTPOJID2 Strong Biomarker [117]
CD8B OTMZ1T7J Strong Biomarker [118]
CENPV OTPQ0KT9 Strong Biomarker [119]
CFHR1 OT72R16T Strong Genetic Variation [120]
CGAS OTJYIXNB Strong Biomarker [121]
CHST12 OTHRMYJG Strong Biomarker [122]
CIITA OTRJNZFO Strong Altered Expression [45]
CORO1A OTVAZOHC Strong Biomarker [123]
CPD OT2CS64Y Strong Biomarker [124]
CREM OTJIJ5AL Strong Biomarker [125]
CTBP2 OTGZGT87 Strong Biomarker [126]
DLAT OT9LBJVN Strong Altered Expression [127]
DOCK11 OTFSTN6A Strong Genetic Variation [128]
DUOX1 OTQ2AEW0 Strong Biomarker [129]
DUSP4 OT6WAO12 Strong Biomarker [125]
EFNA2 OTEAUKRX Strong Biomarker [52]
EGR2 OTAVQ78J Strong Biomarker [130]
ELF1 OTV5LKIA Strong Biomarker [52]
ELOF1 OT8BXS5U Strong Biomarker [52]
FAM167A OT9JF3JQ Strong Genetic Variation [131]
FCGR2C OTNLMNYB Strong Biomarker [24]
FCGR3B OTSLSPZG Strong Biomarker [26]
FLII OT7G9JG6 Strong Biomarker [93]
H1-0 OTRLJK4Z Strong Biomarker [132]
H3C13 OT97FS6C Strong Biomarker [133]
HIVEP3 OTM3QT3L Strong Altered Expression [134]
HMGN2 OTN20MEF Strong Biomarker [132]
HNRNPC OT47AK4C Strong Biomarker [135]
HNRNPDL OTB3BFCV Strong Biomarker [135]
IER3 OTZJI5FZ Strong Biomarker [136]
IFI6 OTWOOAM4 Strong Genetic Variation [38]
IFIH1 OTZA2AHA Strong Biomarker [137]
IFNK OTO2WDPX Strong Biomarker [138]
IL34 OTZ15VVK Strong Altered Expression [139]
IRF7 OTC1A2PQ Strong Biomarker [122]
KIR2DL4 OTXN18OA Strong Biomarker [140]
KIR3DL1 OTPOSXFX Strong Altered Expression [12]
LARP6 OTUQ9QS9 Strong Biomarker [141]
LBH OT87AT1X Strong Genetic Variation [142]
LY6E OTMG16BZ Strong Biomarker [143]
MAEA OTPA2FDE Strong Altered Expression [144]
MASP1 OTWWCNZP Strong Biomarker [145]
MAVS OTTQ0J64 Strong Biomarker [146]
MRTFA OTCVXASM Strong Biomarker [147]
MSH5 OTDARQT3 Strong Biomarker [148]
MYDGF OT9HRPL6 Strong Biomarker [54]
NAA16 OTWMA7LK Strong Biomarker [74]
NBEAL2 OTMCAXWR Strong Biomarker [149]
NCF2 OTAUW7L2 Strong Biomarker [150]
NT5C3A OT67KZJA Strong Biomarker [151]
OASL OTZ05YRP Strong Biomarker [152]
OCA2 OTDWIGBF Strong Biomarker [153]
ORMDL3 OTAB7MZF Strong Altered Expression [154]
PADI2 OTT40K94 Strong Biomarker [67]
PBX1 OTORABGO Strong Genetic Variation [155]
PC OT6O0V51 Strong Biomarker [156]
PHRF1 OT21KEGX Strong Genetic Variation [148]
PRDM1 OTQLSVBS Strong Altered Expression [157]
PROCR OTRHED17 Strong Biomarker [158]
PSME3 OTSTC4YY Strong Biomarker [159]
PTPN22 OTDCNTC3 Strong Biomarker [61]
RAB4A OT7BL9WW Strong Genetic Variation [160]
RELB OTU3QYEF Strong Biomarker [161]
RPA1 OT76POLP Strong Biomarker [162]
RPL17 OTTYMPS6 Strong Genetic Variation [163]
RPS19 OTBKGP48 Strong Biomarker [164]
RUNX1T1 OT30DED5 Strong Biomarker [91]
SCYL1 OTQ0IN7P Strong Biomarker [165]
SGMS1 OTZQE7PW Strong Biomarker [166]
SH2B2 OTEDHHDH Strong Biomarker [167]
SH2D1A OTLU49I5 Strong Altered Expression [168]
SH3BP2 OT90JNBS Strong Biomarker [169]
SIGLEC1 OTNWSQA9 Strong Biomarker [170]
SIGLEC14 OT2JGGXD Strong Altered Expression [171]
SLAMF1 OTBTT3ZQ Strong Genetic Variation [172]
SNRNP70 OTP52YZ3 Strong Biomarker [173]
SNRPA OT02TSQT Strong Biomarker [174]
SNRPB OT3UJ4ZU Strong Altered Expression [175]
SRCIN1 OTQZNQQ5 Strong Biomarker [62]
SRI OT4R3EAC Strong Genetic Variation [176]
SSB OTCCTPBR Strong Altered Expression [177]
STAT4 OTAK3VFR Strong Genetic Variation [178]
SYNPO OTICDJAB Strong Biomarker [179]
TREX1 OTQG7K12 Strong Genetic Variation [180]
TRIM38 OT6SP1M9 Strong Biomarker [181]
TSC22D3 OT03UM03 Strong Altered Expression [182]
CCL14 OT8QETQU Definitive Genetic Variation [183]
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⏷ Show the Full List of 117 DOT(s)

References

1 ClinicalTrials.gov (NCT02201524) Study to Evaluate PF-04965842 in Patients With Moderate to Severe Psoriasis. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT01972568) Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7639).
5 Clinical pipeline report, company report or official report of Biogen Idec.
6 ClinicalTrials.gov (NCT01487551) An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis Patients Treated With ABR-215757 (Paquinimod). U.S. National Institutes of Health.
7 ClinicalTrials.gov (NCT02224651) Study to Evaluate Safety and Tolerability of Single Ascending Doses of Multiple Formulations of PF-06650833 in Healthy Subjects Under Fasted and Fed Conditions. U.S. National Institutes of Health.
8 Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019789)
10 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
11 Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.Nat Commun. 2019 May 17;10(1):2201. doi: 10.1038/s41467-019-10242-9.
12 CD4+CD28+KIR+CD11a(hi) T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients.J Autoimmun. 2018 Jan;86:19-28. doi: 10.1016/j.jaut.2017.09.011. Epub 2017 Oct 20.
13 PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.JCI Insight. 2019 Oct 17;4(20):e130062. doi: 10.1172/jci.insight.130062.
14 The investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosis.Clin Rheumatol. 2016 Apr;35(4):919-25. doi: 10.1007/s10067-016-3222-0. Epub 2016 Mar 9.
15 Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus.J Autoimmun. 2019 Jan;96:59-73. doi: 10.1016/j.jaut.2018.08.005. Epub 2018 Aug 30.
16 TWEAK/Fn14 Activation Contributes to the Pathogenesis of Bullous Pemphigoid.J Invest Dermatol. 2017 Jul;137(7):1512-1522. doi: 10.1016/j.jid.2017.03.019. Epub 2017 Mar 27.
17 Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16.EMBO Rep. 2018 Oct;19(10):e45737. doi: 10.15252/embr.201845737. Epub 2018 Aug 13.
18 Laboratory Diagnostics in Thrombophilia.Hamostaseologie. 2019 Feb;39(1):49-61. doi: 10.1055/s-0039-1677840. Epub 2019 Jan 31.
19 Association study of CD154 polymorphisms and serum CD154 level with systemic lupus erythematous in Chinese population.Rheumatol Int. 2017 Aug;37(8):1287-1294. doi: 10.1007/s00296-017-3745-y. Epub 2017 May 26.
20 Therapeutic Interventions of Tissue Specific Autoimmune Onset in Systemic Lupus Erythematosus. Mini Rev Med Chem. 2017;17(15):1418-1424.
21 CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities.Clin Immunol. 2015 Dec;161(2):120-7. doi: 10.1016/j.clim.2015.08.010. Epub 2015 Aug 30.
22 NOX2 mediates quiescent handling of dead cell remnants in phagocytes.Redox Biol. 2019 Sep;26:101279. doi: 10.1016/j.redox.2019.101279. Epub 2019 Jul 20.
23 Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.Sci Rep. 2019 Jun 20;9(1):8993. doi: 10.1038/s41598-019-45299-5.
24 Targeted silencing of DNA-specific B cells combined with partial plasma cell depletion displays additive effects on delaying disease onset in lupus-prone mice.Clin Exp Immunol. 2013 Nov;174(2):221-8. doi: 10.1111/cei.12164.
25 The Synergy of Endotoxin and (1?)--D-Glucan, from Gut Translocation, Worsens Sepsis Severity in a Lupus Model of Fc Gamma Receptor IIb-Deficient Mice.J Innate Immun. 2018;10(3):189-201. doi: 10.1159/000486321. Epub 2018 Jan 31.
26 The role of neutrophils in skin damage induced by tissue-deposited lupus IgG.Immunology. 2018 Feb 16;154(4):604-12. doi: 10.1111/imm.12908. Online ahead of print.
27 Upregulated expression of STAT3/IL-17 in patients with systemic lupus erythematosus.Clin Rheumatol. 2019 May;38(5):1361-1366. doi: 10.1007/s10067-019-04467-8. Epub 2019 Feb 15.
28 Upregulated IL-1 Receptor-associated Kinase 1 (IRAK1) in Systemic Lupus Erythematosus: IRAK1 Inhibition Represses Th17 Differentiation with Therapeutic Potential.Immunol Invest. 2018 Jul;47(5):468-483. doi: 10.1080/08820139.2018.1458105. Epub 2018 Apr 3.
29 Cis interaction between sialylated FcRIIA and the I-domain of Mac-1 limits antibody-mediated neutrophil recruitment.Nat Commun. 2018 Nov 29;9(1):5058. doi: 10.1038/s41467-018-07506-1.
30 Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.J Clin Invest. 2009 Apr;119(4):911-23. doi: 10.1172/JCI36728.
31 Exostosin 1/Exostosin 2-Associated Membranous Nephropathy.J Am Soc Nephrol. 2019 Jun;30(6):1123-1136. doi: 10.1681/ASN.2018080852. Epub 2019 May 6.
32 Anti-heparan sulfate antibody and functional loss of glomerular heparan sulfate proteoglycans in lupus nephritis.Lupus. 2017 Jul;26(8):815-824. doi: 10.1177/0961203316678674. Epub 2016 Dec 21.
33 Postactivated B cells in systemic lupus erythematosus: update on translational aspects and therapeutic considerations.Curr Opin Rheumatol. 2019 Mar;31(2):175-184. doi: 10.1097/BOR.0000000000000576.
34 Knockdown of TRIM27 expression suppresses the dysfunction of mesangial cells in lupus nephritis by FoxO1 pathway.J Cell Physiol. 2019 Jul;234(7):11555-11566. doi: 10.1002/jcp.27810. Epub 2019 Jan 15.
35 Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells.Biochem Genet. 2019 Feb;57(1):35-45. doi: 10.1007/s10528-018-9871-8. Epub 2018 Jul 13.
36 B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.J Immunol. 2019 Feb 1;202(3):664-674. doi: 10.4049/jimmunol.1801207. Epub 2019 Jan 4.
37 Haemophagocytic lymphohistiocytosis with collapsing lupus podocytopathy as an unusual manifestation of systemic lupus erythematosus with APOL1 double-risk alleles.BMJ Case Rep. 2019 Jan 14;12(1):bcr-2018-227860. doi: 10.1136/bcr-2018-227860.
38 Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse.J Autoimmun. 2013 Mar;41:168-74. doi: 10.1016/j.jaut.2012.12.012. Epub 2013 Feb 18.
39 Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).J Med Chem. 2019 Apr 11;62(7):3228-3250. doi: 10.1021/acs.jmedchem.9b00167. Epub 2019 Mar 29.
40 Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells.JCI Insight. 2018 Jul 12;3(13):e99711. doi: 10.1172/jci.insight.99711.
41 Clinical & immunological characteristics in systemic lupus erythematosus patients.Indian J Med Res. 2017 Aug;146(2):224-229. doi: 10.4103/ijmr.IJMR_1356_15.
42 Netting Neutrophils Activate Autoreactive B Cells in Lupus.J Immunol. 2018 May 15;200(10):3364-3371. doi: 10.4049/jimmunol.1700778. Epub 2018 Apr 9.
43 A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus.J Leukoc Biol. 2015 Feb;97(2):425-33. doi: 10.1189/jlb.6A0214-097R. Epub 2014 Dec 16.
44 Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.Immunity. 2004 Dec;21(6):769-80. doi: 10.1016/j.immuni.2004.10.009.
45 Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells.Ann Rheum Dis. 2019 Apr;78(4):519-528. doi: 10.1136/annrheumdis-2018-214323. Epub 2019 Jan 23.
46 Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells.Lupus. 2011 Nov;20(13):1365-71. doi: 10.1177/0961203311413412. Epub 2011 Aug 24.
47 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.Front Immunol. 2018 May 9;9:1053. doi: 10.3389/fimmu.2018.01053. eCollection 2018.
48 Elevated production of serum B-cell-attracting chemokine-1 (BCA-1/CXCL13) is correlated with childhood-onset lupus disease activity, severity, and renal involvement.Lupus. 2011 Jul;20(8):845-54. doi: 10.1177/0961203311398513. Epub 2011 May 16.
49 CXCR5 is critically involved in progression of lupus through regulation of B cell and double-negative T cell trafficking.Clin Exp Immunol. 2016 Jul;185(1):22-32. doi: 10.1111/cei.12791. Epub 2016 Apr 18.
50 Physical Activity and Genome-wide DNA Methylation: The REgistre GIron del COR Study.Med Sci Sports Exerc. 2020 Mar;52(3):589-597. doi: 10.1249/MSS.0000000000002174.
51 Prothrombotic risk factors in childhood stroke and venous thrombosis.Eur J Pediatr. 1999 Dec;158 Suppl 3:S117-21. doi: 10.1007/pl00014333.
52 PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells.J Immunol. 2008 Sep 1;181(5):3658-64. doi: 10.4049/jimmunol.181.5.3658.
53 Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus.Front Immunol. 2019 Oct 25;10:2512. doi: 10.3389/fimmu.2019.02512. eCollection 2019.
54 The cytokine network type I IFN-IL-27-IL-10 is augmented in murine and human lupus.J Leukoc Biol. 2019 Oct;106(4):967-975. doi: 10.1002/JLB.3AB0518-180RR. Epub 2019 Jun 19.
55 Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice.J Exp Med. 2003 Mar 17;197(6):777-88. doi: 10.1084/jem.20021996.
56 Interleukin-17/Interleukin-21 and Interferon- producing T cells specific for 2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome.Haematologica. 2019 Dec;104(12):2519-2527. doi: 10.3324/haematol.2018.209536. Epub 2019 Mar 14.
57 Interleukin-21 is increased in active systemic lupus erythematosus patients and contributes to the generation of plasma B cells.Clin Exp Rheumatol. 2013 Mar-Apr;31(2):172-9. Epub 2012 Nov 6.
58 Utility of CD123 immunohistochemistry in differentiating lupus erythematosus from cutaneous T cell lymphoma.Histopathology. 2019 May;74(6):908-916. doi: 10.1111/his.13817. Epub 2019 Mar 20.
59 Deficiency in IRAK4 activity attenuates manifestations of murine Lupus.Eur J Immunol. 2017 May;47(5):880-891. doi: 10.1002/eji.201646641. Epub 2017 Mar 31.
60 CD8+CD103+ iTregs inhibit the progression of lupus nephritis by attenuating glomerular endothelial cell injury.Rheumatology (Oxford). 2019 Nov 1;58(11):2039-2050. doi: 10.1093/rheumatology/kez112.
61 IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups.Hum Immunol. 2015 Jul;76(7):525-31. doi: 10.1016/j.humimm.2015.06.001. Epub 2015 Jun 17.
62 Lupus Regulator Peptide P140 Represses B Cell Differentiation by Reducing HLA Class II Molecule Overexpression.Arthritis Rheumatol. 2018 Jul;70(7):1077-1088. doi: 10.1002/art.40470. Epub 2018 May 15.
63 IgG phosphatidylserine/prothrombin antibodies as a risk factor of thrombosis in antiphospholipid antibody carriers.Thromb Res. 2019 May;177:157-160. doi: 10.1016/j.thromres.2019.03.006. Epub 2019 Mar 8.
64 Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients.Ann Rheum Dis. 2013 Apr;72(4):596-601. doi: 10.1136/annrheumdis-2012-202024. Epub 2012 Aug 17.
65 Mannose-binding lectin (MBL) codon 54 (rs1800450) polymorphism predisposes towards medium vessel vasculitis in patients with systemic lupus erythematosus.Clin Rheumatol. 2017 Apr;36(4):837-843. doi: 10.1007/s10067-017-3539-3. Epub 2017 Jan 17.
66 Milk fat globule-EGF factor 8 suppresses the aberrant immune response of systemic lupus erythematosus-derived neutrophils and associated tissue damage.Cell Death Differ. 2017 Feb;24(2):263-275. doi: 10.1038/cdd.2016.115. Epub 2016 Oct 21.
67 Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.JCI Insight. 2018 Dec 6;3(23):e124729. doi: 10.1172/jci.insight.124729.
68 Phosphodiesterase 7A: a new therapeutic target for alleviating chronic inflammation?.Curr Pharm Des. 2006;12(25):3207-20. doi: 10.2174/138161206778194123.
69 RNA editing blood biomarkers for predicting mood alterations in HCV patients.J Neurovirol. 2019 Dec;25(6):825-836. doi: 10.1007/s13365-019-00772-9. Epub 2019 Jul 22.
70 PKK deficiency in B cells prevents lupus development in Sle lupus mice.Immunol Lett. 2017 May;185:1-11. doi: 10.1016/j.imlet.2017.03.002. Epub 2017 Mar 6.
71 XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris).PLoS One. 2017 Oct 20;12(10):e0186331. doi: 10.1371/journal.pone.0186331. eCollection 2017.
72 SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype.Front Immunol. 2018 Sep 11;9:2081. doi: 10.3389/fimmu.2018.02081. eCollection 2018.
73 Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.J Autoimmun. 2014 May;50:87-98. doi: 10.1016/j.jaut.2014.01.002. Epub 2014 Feb 7.
74 Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus.Adv Exp Med Biol. 1999;455:147-52. doi: 10.1007/978-1-4615-4857-7_21.
75 RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.Arthritis Res Ther. 2010;12(6):R227. doi: 10.1186/ar3214. Epub 2010 Dec 30.
76 Transgelin-2 is upregulated on activated B-cells and expressed in hyperplastic follicles in lupus erythematosus patients.PLoS One. 2017 Sep 14;12(9):e0184738. doi: 10.1371/journal.pone.0184738. eCollection 2017.
77 Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus.J Rheumatol. 2007 Jan;34(1):89-96. Epub 2006 Nov 15.
78 Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells.Curr Top Microbiol Immunol. 2017;410:29-45. doi: 10.1007/82_2017_59.
79 Treatment of murine lupus with TIGIT-Ig.Clin Immunol. 2019 Jun;203:72-80. doi: 10.1016/j.clim.2019.04.007. Epub 2019 Apr 18.
80 The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5(+)CD1d(hi)FcRIIb(hi) Regulatory B-Cell Subset in Lupus.J Invest Dermatol. 2017 Dec;137(12):2532-2543. doi: 10.1016/j.jid.2017.07.843. Epub 2017 Aug 24.
81 Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.PLoS One. 2014 Jul 10;9(7):e102284. doi: 10.1371/journal.pone.0102284. eCollection 2014.
82 TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus.Eur J Immunol. 2017 Apr;47(4):713-723. doi: 10.1002/eji.201646630.
83 Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. Nov-Dec 2019;37(6):906-914.
84 A replication study from Chinese supports association between lupus-risk allele in TNFSF4 and renal disorder.Biomed Res Int. 2013;2013:597921. doi: 10.1155/2013/597921. Epub 2013 Jul 1.
85 Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression.J Autoimmun. 2017 Mar;78:92-100. doi: 10.1016/j.jaut.2016.12.010. Epub 2017 Jan 11.
86 CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism.Sci Rep. 2018 Feb 20;8(1):3357. doi: 10.1038/s41598-018-21337-6.
87 PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.Sci Transl Med. 2019 Dec 11;11(522):eaax1159. doi: 10.1126/scitranslmed.aax1159.
88 Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production.Clin Exp Rheumatol. 2014 Sep-Oct;32(5):705-14. Epub 2014 Aug 15.
89 Genome-wide differential expression reveals candidate genes involved in the pathogenesis of lupus and lupus nephritis.Int J Rheum Dis. 2016 Jan;19(1):55-64. doi: 10.1111/1756-185X.12745. Epub 2015 Sep 25.
90 Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus.Arthritis Rheumatol. 2017 Jan;69(1):131-142. doi: 10.1002/art.39810. Epub 2016 Dec 2.
91 Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 D-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3.Autoimmunity. 2017 Feb;50(1):42-51. doi: 10.1080/08916934.2016.1272597.
92 p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene.Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2685-9. doi: 10.1073/pnas.90.7.2685.
93 Fli-1, a Functional Factor Performed in Autoimmune Lupus.Inflammation. 2016 Feb;39(1):493-498. doi: 10.1007/s10753-015-0257-3.
94 Role of Lgals9 Deficiency in Attenuating Nephritis and Arthritis in BALB/c Mice in a Pristane-Induced Lupus Model.Arthritis Rheumatol. 2018 Jul;70(7):1089-1101. doi: 10.1002/art.40467. Epub 2018 May 24.
95 Diagnostic Utility of Separate Anti-Ro60 and Anti-Ro52/TRIM21 Antibody Detection in Autoimmune Diseases.Front Immunol. 2019 Mar 12;10:444. doi: 10.3389/fimmu.2019.00444. eCollection 2019.
96 Beta-adducin and sodium-calcium exchanger 1 gene variants are associated with systemic lupus erythematosus and lupus nephritis.Rheumatol Int. 2015 Dec;35(12):1975-83. doi: 10.1007/s00296-015-3298-x. Epub 2015 Jun 5.
97 CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.J Clin Invest. 2018 Aug 1;128(8):3445-3459. doi: 10.1172/JCI99507. Epub 2018 Jul 9.
98 CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus.Ann Rheum Dis. 2008 Aug;67(8):1076-83. doi: 10.1136/ard.2007.078048. Epub 2007 Oct 30.
99 Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.Mol Cell Endocrinol. 2015 Nov 5;415:45-55. doi: 10.1016/j.mce.2015.08.003. Epub 2015 Aug 12.
100 Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.J Immunol. 2019 Apr 1;202(7):2121-2130. doi: 10.4049/jimmunol.1800650. Epub 2019 Feb 11.
101 The Sgp3 locus derived from the 129 strain is responsible for enhanced endogenous retroviral expression in macroH2A1-deficient mice.J Autoimmun. 2010 Dec;35(4):398-403. doi: 10.1016/j.jaut.2010.08.003. Epub 2010 Sep 15.
102 Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus.J Autoimmun. 2013 Mar;41:92-9. doi: 10.1016/j.jaut.2013.01.005. Epub 2013 Jan 20.
103 Associations Between Classification Criteria Items in Systemic Lupus Erythematosus.Arthritis Care Res (Hoboken). 2020 Dec;72(12):1820-1826. doi: 10.1002/acr.24078. Epub 2020 Nov 7.
104 A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.PLoS Genet. 2012 Jan;8(1):e1002455. doi: 10.1371/journal.pgen.1002455. Epub 2012 Jan 26.
105 Low apolipoprotein M serum levels correlate with Systemic lupus erythematosus disease activity and apolipoprotein M gene polymorphisms with Lupus.Lipids Health Dis. 2017 May 5;16(1):88. doi: 10.1186/s12944-017-0476-8.
106 Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells.J Immunol. 2015 Feb 1;194(3):940-9. doi: 10.4049/jimmunol.1401941. Epub 2014 Dec 22.
107 Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4(+) T cells of systemic lupus erythematosus.Clin Immunol. 2018 Feb;187:113-121. doi: 10.1016/j.clim.2017.11.002. Epub 2017 Nov 4.
108 Rare diseases that mimic Systemic Lupus Erythematosus (Lupus mimickers).Joint Bone Spine. 2019 Mar;86(2):165-171. doi: 10.1016/j.jbspin.2018.10.007. Epub 2018 Oct 26.
109 Evaluation of C1q genomic region in minority racial groups of lupus.Genes Immun. 2009 Jul;10(5):517-24. doi: 10.1038/gene.2009.33. Epub 2009 May 14.
110 Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy.Lupus. 2005;14(5):356-62. doi: 10.1191/0961203305lu2093oa.
111 Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease.Arthritis Rheum. 1978 Nov-Dec;21(8):958-67. doi: 10.1002/art.1780210813.
112 Characterization of type I complement C2 deficiency MHC haplotypes. Strong conservation of the complotype/HLA-B-region and absence of disease association due to linked class II genes.J Immunol. 1993 Nov 15;151(10):5856-63.
113 Effects of Arsenic Trioxide on INF-gamma Gene Expression in MRL/lpr Mice and Human Lupus. Biol Trace Elem Res. 2018 Aug;184(2):391-397. doi: 10.1007/s12011-017-1206-9. Epub 2017 Nov 20.
114 CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.Front Immunol. 2018 Nov 15;9:2643. doi: 10.3389/fimmu.2018.02643. eCollection 2018.
115 Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity.J Immunol. 2011 Jul 1;187(1):21-5. doi: 10.4049/jimmunol.1100510. Epub 2011 May 27.
116 Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice.Int Immunol. 2011 Feb;23(2):149-58. doi: 10.1093/intimm/dxq465. Epub 2011 Jan 28.
117 CD72 is a Negative Regulator of B Cell Responses to Nuclear Lupus Self-antigens and Development of Systemic Lupus Erythematosus.Immune Netw. 2019 Feb 13;19(1):e1. doi: 10.4110/in.2019.19.e1. eCollection 2019 Feb.
118 cAMP responsive element modulator (CREM) mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.J Biol Chem. 2014 Jan 24;289(4):2361-70. doi: 10.1074/jbc.M113.523605. Epub 2013 Dec 2.
119 Type-C RNA virus gene expression in human tissue.J Virol. 1974 Dec;14(6):1584-96. doi: 10.1128/JVI.14.6.1584-1596.1974.
120 Use of eculizumab in a systemic lupus erythemathosus patient presenting thrombotic microangiopathy and heterozygous deletion in CFHR1-CFHR3. A case report and systematic review.Clin Rheumatol. 2017 Dec;36(12):2859-2867. doi: 10.1007/s10067-017-3823-2. Epub 2017 Sep 13.
121 Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus.Arthritis Rheumatol. 2017 Apr;69(4):800-807. doi: 10.1002/art.40002. Epub 2017 Mar 7.
122 Renal involvement in lupus is characterized by unique DNA methylation changes in nave CD4+ T cells.J Autoimmun. 2015 Jul;61:29-35. doi: 10.1016/j.jaut.2015.05.003. Epub 2015 May 23.
123 Genetics of SLE: evidence from mouse models.Nat Rev Rheumatol. 2010 Jun;6(6):348-57. doi: 10.1038/nrrheum.2010.63. Epub 2010 May 4.
124 Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus.J Clin Immunol. 2007 Nov;27(6):568-79. doi: 10.1007/s10875-007-9118-7. Epub 2007 Jul 20.
125 cAMP Response Element Modulator Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.J Immunol. 2019 Dec 1;203(11):2807-2816. doi: 10.4049/jimmunol.1900760. Epub 2019 Oct 25.
126 Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.J Immunol. 2017 Jun 1;198(11):4268-4276. doi: 10.4049/jimmunol.1601705. Epub 2017 Apr 24.
127 Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients.Rheumatology (Oxford). 2006 Jun;45(6):694-702. doi: 10.1093/rheumatology/kei244. Epub 2006 Jan 17.
128 Estrogen receptor alpha gene polymorphism and systemic lupus erythematosus: a possible risk?.Lupus. 2005;14(5):391-8. doi: 10.1191/0961203305lu2104oa.
129 Activation of Peroxisome Proliferator Activator Receptor / Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus.Hypertension. 2017 Apr;69(4):641-650. doi: 10.1161/HYPERTENSIONAHA.116.08655. Epub 2017 Feb 27.
130 Early growth response transcription factors and the modulation of immune response: implications towards autoimmunity.Autoimmun Rev. 2010 Apr;9(6):454-8. doi: 10.1016/j.autrev.2009.12.006. Epub 2009 Dec 23.
131 Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.Am J Hum Genet. 2014 Apr 3;94(4):586-98. doi: 10.1016/j.ajhg.2014.03.008.
132 Rabbit anti-HMG-17 antibodies recognize similar epitopes on the HMG-17 molecule as lupus autoantibodies. Relation with histone H1 defined epitopes.J Pept Sci. 2002 Dec;8(12):683-94. doi: 10.1002/psc.429.
133 Comprehensive Longitudinal Surveillance of the IgG Autoantibody Repertoire in Established Systemic Lupus Erythematosus.Arthritis Rheumatol. 2019 May;71(5):736-743. doi: 10.1002/art.40788. Epub 2019 Mar 24.
134 Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.Mol Immunol. 2013 May;54(1):23-31. doi: 10.1016/j.molimm.2012.10.026. Epub 2012 Nov 22.
135 Neuronal BC RNA Transport Impairments Caused by Systemic Lupus Erythematosus Autoantibodies.J Neurosci. 2019 Sep 25;39(39):7759-7777. doi: 10.1523/JNEUROSCI.1657-18.2019. Epub 2019 Aug 12.
136 Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):878-83. doi: 10.1073/pnas.022326699. Epub 2002 Jan 8.
137 Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5.J Immunol. 2019 Sep 1;203(5):1356-1368. doi: 10.4049/jimmunol.1900354. Epub 2019 Jul 31.
138 Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine TypeIInterferon Loop.J Invest Dermatol. 2017 Jan;137(1):115-122. doi: 10.1016/j.jid.2016.09.008. Epub 2016 Sep 16.
139 Targeting IL-34 in inflammatory autoimmune diseases.J Cell Physiol. 2019 Dec;234(12):21810-21816. doi: 10.1002/jcp.28946. Epub 2019 Jun 7.
140 Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells.J Immunol. 2009 Sep 1;183(5):3481-7. doi: 10.4049/jimmunol.0900034. Epub 2009 Aug 12.
141 The novel lupus antigen related protein acheron enhances the development of human breast cancer.Int J Cancer. 2012 Feb 1;130(3):544-54. doi: 10.1002/ijc.26015. Epub 2011 May 9.
142 LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.Arthritis Rheumatol. 2016 Nov;68(11):2637-2645. doi: 10.1002/art.39746.
143 Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients.Lupus. 2008 Sep;17(9):805-13. doi: 10.1177/0961203308089694.
144 Differential tissue expression of erythroblast macrophage protein in a MRL/lpr mouse model of lupus.Lupus. 2019 Jun;28(7):843-853. doi: 10.1177/0961203319851572. Epub 2019 May 27.
145 Essential Roles for Mannose-Binding Lectin-Associated Serine Protease-1/3 in the Development of Lupus-Like Glomerulonephritis in MRL/lpr Mice.Front Immunol. 2018 May 28;9:1191. doi: 10.3389/fimmu.2018.01191. eCollection 2018.
146 Antiviral Adaptor MAVS Promotes Murine Lupus With a B Cell Autonomous Role.Front Immunol. 2019 Oct 16;10:2452. doi: 10.3389/fimmu.2019.02452. eCollection 2019.
147 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.J Clin Invest. 2015 Jul 1;125(7):2877-90. doi: 10.1172/JCI81059. Epub 2015 Jun 22.
148 Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.Arthritis Rheum. 2011 Nov;63(11):3493-501. doi: 10.1002/art.30563.
149 Energetics and evasion dynamics of large predators and prey: pumas vs. hounds.PeerJ. 2017 Aug 17;5:e3701. doi: 10.7717/peerj.3701. eCollection 2017.
150 Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.Arthritis Rheumatol. 2017 Aug;69(8):1647-1660. doi: 10.1002/art.40141. Epub 2017 Jul 5.
151 Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions.J Biol Chem. 1996 Jan 12;271(2):1118-26. doi: 10.1074/jbc.271.2.1118.
152 Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study.Clin Rheumatol. 2007 Feb;26(2):186-90. doi: 10.1007/s10067-006-0260-z. Epub 2006 Mar 25.
153 Anti-ribosomal P protein antibodies influence mortality of patients with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematous involving a severe form of the disease.Mod Rheumatol. 2019 Jul;29(4):612-618. doi: 10.1080/14397595.2018.1508801. Epub 2018 Sep 5.
154 ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.J Immunol. 2017 Sep 1;199(5):1647-1659. doi: 10.4049/jimmunol.1602124. Epub 2017 Jul 26.
155 The PBX1 lupus susceptibility gene regulates CD44 expression.Mol Immunol. 2017 May;85:148-154. doi: 10.1016/j.molimm.2017.02.016. Epub 2017 Mar 1.
156 Effects of oral anticoagulant therapy and haplotype 1 of the endothelial protein C receptor gene on activated protein C levels.Thromb Haemost. 2012 Mar;107(3):448-57. doi: 10.1160/TH11-07-0510. Epub 2012 Jan 25.
157 Up-regulation of transcription factor Blimp1 in systemic lupus erythematosus.Mol Immunol. 2013 Dec;56(4):574-82. doi: 10.1016/j.molimm.2013.05.241. Epub 2013 Aug 1.
158 Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence.Kidney Int. 2005 Jul;68(1):110-20. doi: 10.1111/j.1523-1755.2005.00385.x.
159 Relationships between autoantibody responses to deletion mutants of Ki antigen and clinical manifestations of lupus.J Rheumatol. 2003 Jun;30(6):1208-14.
160 Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.JCI Insight. 2020 Jan 16;5(1):e134010. doi: 10.1172/jci.insight.134010.
161 Rel B-modified dendritic cells possess tolerogenic phenotype and functions on lupus splenic lymphocytes invitro.Immunology. 2016 Sep;149(1):48-61. doi: 10.1111/imm.12628.
162 The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family.J Mol Recognit. 2017 May;30(5). doi: 10.1002/jmr.2600. Epub 2016 Dec 6.
163 A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients.Lupus. 2004;13(7):510-6. doi: 10.1191/0961203303lu1052oa.
164 Assessment of the translational value of mouse lupus models using clinically relevant biomarkers.Transl Res. 2014 Jun;163(6):515-32. doi: 10.1016/j.trsl.2014.01.003. Epub 2014 Jan 6.
165 Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice.Eur J Immunol. 2004 Jun;34(6):1654-62. doi: 10.1002/eji.200324201.
166 Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.EBioMedicine. 2019 Jul;45:578-587. doi: 10.1016/j.ebiom.2019.06.038. Epub 2019 Jun 28.
167 Clinical and immunological features of antiphospholipid syndrome in the elderly: a retrospective national multicentre study.Rheumatology (Oxford). 2019 Jun 1;58(6):1006-1010. doi: 10.1093/rheumatology/key437.
168 Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.J Immunol. 2016 Jun 15;196(12):4915-24. doi: 10.4049/jimmunol.1501523. Epub 2016 May 11.
169 Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Fas(lpr) Mice.Cells. 2019 Apr 30;8(5):402. doi: 10.3390/cells8050402.
170 Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study.Rheumatology (Oxford). 2017 Sep 1;56(9):1618-1626. doi: 10.1093/rheumatology/kex220.
171 Monocyte Siglec-14 expression is upregulated in patients with systemic lupus erythematosus and correlates with lupus disease activity.Rheumatology (Oxford). 2017 Jun 1;56(6):1025-1030. doi: 10.1093/rheumatology/kew498.
172 Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus.PLoS One. 2017 Oct 11;12(10):e0186073. doi: 10.1371/journal.pone.0186073. eCollection 2017.
173 U1RNP antibody-positive neonatal lupus. A report of two cases with immunogenetic studies.Arch Dermatol. 1992 Nov;128(11):1490-4.
174 Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3551-6. doi: 10.1073/pnas.0306267101. Epub 2004 Feb 26.
175 Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'.Biochem Biophys Res Commun. 2001 Aug 3;285(5):1206-12. doi: 10.1006/bbrc.2001.5302.
176 Clinical SLEDAI-2K zero may be a pragmatic outcome measure in SLE studies.Expert Opin Biol Ther. 2019 Feb;19(2):157-168. doi: 10.1080/14712598.2019.1561856. Epub 2018 Dec 27.
177 Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus.Arthritis Res Ther. 2019 Nov 29;21(1):259. doi: 10.1186/s13075-019-2056-y.
178 A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.Hum Mol Genet. 2018 Jul 1;27(13):2392-2404. doi: 10.1093/hmg/ddy140.
179 Mesenchymal stem cells prevent podocyte injury in lupus-prone B6.MRL-Faslpr mice via polarizing macrophage into an anti-inflammatory phenotype.Nephrol Dial Transplant. 2019 Apr 1;34(4):597-605. doi: 10.1093/ndt/gfy195.
180 cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.J Autoimmun. 2019 Jun;100:84-94. doi: 10.1016/j.jaut.2019.03.001. Epub 2019 Mar 11.
181 A 1.1-Mb transcript map of the hereditary hemochromatosis locus.Genome Res. 1997 May;7(5):441-56. doi: 10.1101/gr.7.5.441.
182 Could GILZ Be the Answer to Glucocorticoid Toxicity in Lupus?.Front Immunol. 2019 Jul 17;10:1684. doi: 10.3389/fimmu.2019.01684. eCollection 2019.
183 CCL genes in multiple sclerosis and systemic lupus erythematosus.J Neuroimmunol. 2008 Aug 30;200(1-2):145-52. doi: 10.1016/j.jneuroim.2008.05.016. Epub 2008 Jul 3.