Details of the Drug Combination

General Information of Drug Combination (ID: DCL3SV1)

Drug Combination Name
Ibuprofen Capsaicin
Indication
Disease Entry Status REF
Osteoarthritis, Knee Phase 1 [1]
Component Drugs Ibuprofen   DM8VCBE Capsaicin   DMGMF6V
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ibuprofen
Disease Entry ICD 11 Status REF
Dysmenorrhea GA34.3 Approved [2]
Fever MG26 Approved [2]
Headache 8A80-8A84 Approved [2]
Osteoarthritis FA00-FA05 Approved [2]
Pain MG30-MG3Z Approved [3]
Patent ductus arteriosus N.A. Approved [2]
Ibuprofen Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
C-X-C chemokine receptor type 1 (CXCR1) TTMWT8Z CXCR1_HUMAN Inhibitor [11]
Interleukin-8 (IL8) TTCTE1G IL8_HUMAN Inhibitor [12]
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Inhibitor [11]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [13]
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Ibuprofen Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [14]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [15]
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Ibuprofen Interacts with 9 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [16]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [17]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [18]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [18]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [19]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [19]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [19]
Alpha-methylacyl-CoA racemase (AMACR) DEGKWJB AMACR_HUMAN Metabolism [20]
Acyl-CoA thioesterase 2 (ACOT2) DEMEPVJ ACOT2_HUMAN Metabolism [21]
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⏷ Show the Full List of 9 DME(s)
Ibuprofen Interacts with 122 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Activity [22]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [22]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [22]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [22]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [22]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [23]
Annexin A9 (ANXA9) OTKNYMU2 ANXA9_HUMAN Decreases Expression [24]
Metastasis-associated protein MTA2 (MTA2) OTCCYIQJ MTA2_HUMAN Increases Expression [24]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Affects Expression [24]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Affects Expression [24]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [24]
Peptide YY (PYY) OTXX6AF5 PYY_HUMAN Decreases Expression [24]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Affects Expression [24]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Affects Expression [24]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [24]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) OTPWI88U CEAM1_HUMAN Affects Expression [24]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Affects Expression [24]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Decreases Expression [24]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Increases Expression [24]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Affects Expression [24]
Protein PML (PML) OT6SM2GD PML_HUMAN Affects Expression [24]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Decreases Expression [24]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [24]
Insulinoma-associated protein 1 (INSM1) OTG8RV8E INSM1_HUMAN Decreases Expression [24]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [24]
Desmocollin-1 (DSC1) OTNII6GZ DSC1_HUMAN Affects Expression [24]
Corneodesmosin (CDSN) OTQW4HV6 CDSN_HUMAN Affects Expression [24]
Microtubule-associated protein RP/EB family member 2 (MAPRE2) OTAE3MX4 MARE2_HUMAN Affects Expression [24]
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) OTEH9HGE CA2D3_HUMAN Affects Expression [24]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Affects Expression [24]
Hydroperoxide isomerase ALOXE3 (ALOXE3) OT76J52A LOXE3_HUMAN Affects Expression [24]
Transmembrane protease serine 4 (TMPRSS4) OTCCGY2K TMPS4_HUMAN Affects Expression [24]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8) OT2KFY1S ATS8_HUMAN Increases Expression [24]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [25]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [25]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [25]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Decreases Expression [9]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Increases Expression [9]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [9]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [9]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Decreases Expression [9]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) OTLVN68B AAKB2_HUMAN Decreases Expression [9]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Decreases Expression [9]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [9]
Ribosomal L1 domain-containing protein 1 (RSL1D1) OT3CL4R3 RL1D1_HUMAN Increases Expression [9]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Decreases Expression [9]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [9]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [9]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Decreases Expression [9]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Increases Expression [9]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Increases Expression [9]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Increases Expression [9]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [9]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Increases Expression [9]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [9]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Affects Activity [9]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [9]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [9]
DnaJ homolog subfamily B member 2 (DNAJB2) OTZHPV5M DNJB2_HUMAN Increases Expression [9]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Decreases Expression [9]
ETS domain-containing protein Elk-4 (ELK4) OTVSSEOE ELK4_HUMAN Increases Expression [9]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [9]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [9]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Increases Expression [9]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [9]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Increases Expression [9]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [9]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [9]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [9]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [9]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [9]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Decreases Expression [9]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [9]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [9]
RRP12-like protein (RRP12) OTQQAEH4 RRP12_HUMAN Increases Expression [9]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Increases Expression [9]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Increases Expression [9]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [9]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [9]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Increases Expression [9]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [9]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Decreases Expression [9]
Carboxymethylenebutenolidase homolog (CMBL) OT8H3S3G CMBL_HUMAN Decreases Expression [9]
Protein FAM89A (FAM89A) OTNASAXT FA89A_HUMAN Increases Expression [9]
Protein FAM210B, mitochondrial (FAM210B) OT2QHEQ6 F210B_HUMAN Decreases Expression [9]
Spermatid perinuclear RNA-binding protein (STRBP) OTU7XLZL STRBP_HUMAN Increases Expression [9]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [9]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Increases Expression [9]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [9]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [9]
Dual specificity protein phosphatase 22 (DUSP22) OTEZ3U85 DUS22_HUMAN Increases Expression [9]
Phospholipase A and acyltransferase 2 (PLAAT2) OTI5RMWB PLAT2_HUMAN Increases Expression [9]
Leucine--tRNA ligase, cytoplasmic (LARS1) OT4557NF SYLC_HUMAN Increases Expression [9]
Mitochondrial fission process protein 1 (MTFP1) OT3L6F7U MTFP1_HUMAN Increases Expression [9]
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) OTM3CQZT BIG2_HUMAN Increases Expression [9]
Protein piccolo (PCLO) OTXJZZ98 PCLO_HUMAN Increases Expression [9]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Activity [26]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Decreases Expression [27]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [28]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [29]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Increases Phosphorylation [30]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Expression [31]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [32]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [28]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Localization [33]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [34]
Phosphoglycerate mutase 1 (PGAM1) OTZ5DB06 PGAM1_HUMAN Increases Expression [31]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Affects Expression [31]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Increases Expression [31]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [31]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Affects Expression [31]
Peptidyl-prolyl cis-trans isomerase A (PPIA) OTHJMWQQ PPIA_HUMAN Affects Expression [31]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [35]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [36]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Decreases Activity [37]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Expression [31]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Affects Cleavage [38]
Methylcytosine dioxygenase TET1 (TET1) OTZDHT1D TET1_HUMAN Increases Expression [36]
ATP-dependent RNA helicase DDX1 (DDX1) OT3U8FD0 DDX1_HUMAN Affects Expression [31]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [10]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Decreases Expression [36]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Increases ADR [39]
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⏷ Show the Full List of 122 DOT(s)
Indication(s) of Capsaicin
Disease Entry ICD 11 Status REF
Back pain ME84.Z Approved [4]
Neuropathic pain 8E43.0 Approved [5]
Pain MG30-MG3Z Approved [4]
Peripheral neuropathy 8C0Z Approved [4]
Polyneuropathy N.A. Approved [4]
Postherpetic neuralgia 1E91.5 Approved [4]
Type-1/2 diabetes 5A10-5A11 Approved [4]
Diabetic neuropathy 8C0Z Investigative [4]
Neuralgia N.A. Investigative [4]
Capsaicin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Transient receptor potential cation channel V1 (TRPV1) TTMI6F5 TRPV1_HUMAN Agonist [46]
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Capsaicin Interacts with 9 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [47]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [47]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [47]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [47]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [47]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [47]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [47]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [47]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [47]
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⏷ Show the Full List of 9 DME(s)
Capsaicin Interacts with 118 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Decreases Activity [48]
NPC intracellular cholesterol transporter 1 (NPC1) OTRIPICX NPC1_HUMAN Increases Expression [49]
Delta(14)-sterol reductase TM7SF2 (TM7SF2) OTILU5S7 ERG24_HUMAN Decreases Expression [49]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Decreases Expression [49]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [49]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Decreases Expression [49]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Decreases Expression [49]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [49]
Sterol carrier protein 2 (SCP2) OTPAFCPQ SCP2_HUMAN Decreases Expression [49]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Decreases Expression [49]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [49]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [49]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) OTM0A0DY ACOX1_HUMAN Increases Expression [49]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Increases Phosphorylation [49]
Phosphatidylcholine transfer protein (PCTP) OTM36JXE PPCT_HUMAN Decreases Expression [49]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [50]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [51]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [51]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [51]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [52]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [51]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Increases Expression [51]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Decreases Expression [51]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [40]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [53]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Increases Activity [54]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [51]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [55]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Increases Expression [51]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Expression [51]
Glutamate dehydrogenase 1, mitochondrial (GLUD1) OTXKOCUH DHE3_HUMAN Increases Expression [56]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [57]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [51]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [51]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Increases Expression [58]
Albumin (ALB) OTVMM513 ALBU_HUMAN Increases Expression [56]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [57]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [59]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [57]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [53]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Expression [51]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [60]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Adp-Ribosylation [61]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [62]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [63]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Increases Expression [57]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [43]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [40]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Increases Expression [63]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Localization [61]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Decreases Expression [40]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [57]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Affects Expression [51]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Decreases Expression [64]
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) OTP0961M COX5A_HUMAN Increases Expression [56]
Nucleoside diphosphate kinase B (NME2) OTCYGLHV NDKB_HUMAN Increases Expression [57]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [51]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [51]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [57]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [65]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [65]
Peroxiredoxin-6 (PRDX6) OTS8KC8A PRDX6_HUMAN Increases Expression [56]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Increases Expression [57]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [66]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [51]
Collagen alpha-1(XVIII) chain (COL18A1) OTJFUH6O COIA1_HUMAN Increases Expression [57]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Activity [65]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Activity [67]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Decreases Activity [68]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [61]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [69]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [70]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Increases Expression [40]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Increases Expression [43]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Increases Phosphorylation [40]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [51]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [40]
Casein kinase II subunit beta (CSNK2B) OT2WW7R1 CSK2B_HUMAN Increases Phosphorylation [71]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Increases Phosphorylation [71]
Mucin-5AC (MUC5AC) OTJV8O04 MUC5A_HUMAN Increases Secretion [72]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [51]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Localization [73]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [51]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Expression [51]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Decreases Expression [51]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Increases Expression [51]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Phosphorylation [40]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [51]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [51]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [51]
Small ubiquitin-related modifier 4 (SUMO4) OT9B447E SUMO4_HUMAN Increases Expression [56]
Transient receptor potential cation channel subfamily M member 8 (TRPM8) OT7ACGYK TRPM8_HUMAN Increases Activity [54]
Tumor protein p53-inducible nuclear protein 2 (TP53INP2) OT0GTBXO T53I2_HUMAN Increases Expression [40]
Probable E3 ubiquitin-protein ligase TRIML1 (TRIML1) OTKKSF1S TRIML_HUMAN Increases Expression [40]
Arrestin domain-containing protein 4 (ARRDC4) OTINJ0FX ARRD4_HUMAN Decreases Expression [43]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Decreases Expression [64]
Folliculin (FLCN) OTVM78XM FLCN_HUMAN Increases Expression [40]
Mitogen-activated protein kinase 15 (MAPK15) OT8SW0L7 MK15_HUMAN Increases Expression [40]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [51]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Increases Expression [51]
Optineurin (OPTN) OT2UXWH9 OPTN_HUMAN Increases Expression [40]
Ras-related protein Rab-39B (RAB39B) OTDCLLT0 RB39B_HUMAN Increases Expression [40]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [40]
TNF receptor-associated factor 4 (TRAF4) OTJLRVMC TRAF4_HUMAN Increases Expression [51]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) OT50NR57 PINK1_HUMAN Increases Expression [40]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [61]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) OTPMGIU4 MLP3A_HUMAN Affects Localization [40]
Ras-related GTP-binding protein C (RRAGC) OTV3XCV8 RRAGC_HUMAN Increases Expression [40]
Mucin-5B (MUC5B) OTPW6K5C MUC5B_HUMAN Increases Secretion [74]
Ras-related GTP-binding protein D (RRAGD) OTXLVWAH RRAGD_HUMAN Increases Expression [40]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [40]
Bcl-2-associated transcription factor 1 (BCLAF1) OT7T8H6A BCLF1_HUMAN Increases Expression [51]
F-box/LRR-repeat protein 2 (FBXL2) OT5EZ7PD FBXL2_HUMAN Increases Expression [40]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) OTDCNTC3 PTN22_HUMAN Increases Expression [40]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [40]
NADH-ubiquinone oxidoreductase chain 1 (ND1) OTCLGIXV NU1M_HUMAN Increases Response To Substance [75]
Ecto-NOX disulfide-thiol exchanger 2 (ENOX2) OTMDA97Z ENOX2_HUMAN Increases Response To Substance [76]
Transient receptor potential cation channel subfamily V member 6 (TRPV6) OTZ0LGNO TRPV6_HUMAN Increases Response To Substance [77]
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⏷ Show the Full List of 118 DOT(s)

References

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