Details of the Drug Combination

General Information of Drug Combination (ID: DCYILLX)

Drug Combination Name
Simvastatin Atorvastatin
Indication
Disease Entry Status REF
Diabetes Mellitus, Type 2 Phase 1 [1]
Component Drugs Simvastatin   DM30SGU Atorvastatin   DMF28YC
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Simvastatin
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Approved [2]
Atherosclerosis BD40 Approved [2]
Coronary heart disease BA80.Z Approved [2]
Cystic fibrosis CA25 Approved [2]
Depression 6A70-6A7Z Approved [2]
Hypercholesterolaemia 5C80.0 Approved [3]
Hyperlipidemia 5C80.Z Approved [2]
Hyperlipidemia, familial combined, LPL related N.A. Approved [2]
Hypertriglyceridemia 5C80.1 Approved [2]
Pneumonia CA40 Approved [2]
Primary hypercholesterolemia 5C80.00 Approved [2]
Prostate carcinoma N.A. Approved [2]
Rhinitis FA20 Approved [2]
Type-1/2 diabetes 5A10-5A11 Approved [2]
Stroke 8B20 Investigative [2]
Simvastatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [11]
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Simvastatin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [13]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [14]
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Simvastatin Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [16]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [17]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [18]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [19]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [16]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [16]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [16]
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⏷ Show the Full List of 8 DME(s)
Simvastatin Interacts with 146 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Response To Substance [20]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [21]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases ADR [22]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [23]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [23]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Activity [24]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [24]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Expression [8]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [8]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Decreases Expression [8]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [8]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [8]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Increases Expression [8]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [8]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Decreases Expression [8]
Keratin, type I cytoskeletal 13 (KRT13) OTTYSKGX K1C13_HUMAN Increases Expression [8]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) OTGVC9MY PLCG2_HUMAN Increases Expression [8]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [8]
Calmodulin-like protein 3 (CALML3) OTM8DNQU CALL3_HUMAN Increases Expression [8]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Decreases Expression [8]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Increases Expression [8]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [8]
Macrophage metalloelastase (MMP12) OT9Z7LHM MMP12_HUMAN Increases Expression [8]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [8]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [8]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [8]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Increases Expression [8]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [8]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Increases Expression [8]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [8]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [8]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [8]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [8]
Rho GTPase-activating protein 29 (ARHGAP29) OT8JH4TY RHG29_HUMAN Decreases Expression [8]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Increases Expression [8]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [8]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [8]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Expression [8]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [8]
Spondin-2 (SPON2) OTE7JLNM SPON2_HUMAN Increases Expression [8]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [8]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [8]
Matrix metalloproteinase-28 (MMP28) OTHQZXM1 MMP28_HUMAN Increases Expression [8]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Decreases Expression [8]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [8]
Krueppel-like factor 2 (KLF2) OTIP1UFX KLF2_HUMAN Increases Expression [8]
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) OT6GWW1P NPCL1_HUMAN Decreases Expression [25]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [26]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Expression [26]
Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2) OTX31RLZ KI2S2_HUMAN Decreases Expression [26]
Killer cell lectin-like receptor subfamily F member 1 (KLRF1) OTGHZ7FU KLRF1_HUMAN Decreases Expression [26]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Phosphorylation [27]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Nitrosation [27]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [28]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Increases Expression [29]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [30]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [31]
Suppressor of cytokine signaling 7 (SOCS7) OT503VJG SOCS7_HUMAN Increases Expression [32]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [33]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [34]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [31]
Alpha-actinin-4 (ACTN4) OTCNZAJ5 ACTN4_HUMAN Increases Expression [35]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Degradation [36]
Nephrin (NPHS1) OT21JD3P NPHN_HUMAN Increases Expression [35]
Apolipoprotein M (APOM) OTI3FQQC APOM_HUMAN Decreases Expression [37]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [38]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Activity [39]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [40]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [32]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [41]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [42]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [43]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [44]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [45]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Secretion [46]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Activity [47]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Activity [48]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [49]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Localization [50]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [51]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [52]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [53]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Increases Expression [39]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [31]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [54]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [54]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [55]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Affects Expression [41]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Affects Localization [31]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [56]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [57]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Increases Expression [39]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Decreases Expression [58]
Interleukin-4 receptor subunit alpha (IL4R) OTTXOTCW IL4RA_HUMAN Decreases Expression [32]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [59]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Decreases Expression [32]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [47]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [47]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Affects Expression [60]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Affects Expression [41]
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Increases Activity [61]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [53]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Decreases Expression [40]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Expression [58]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [62]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) OT2TTZPZ CDN2D_HUMAN Increases Expression [63]
Ras-related C3 botulinum toxin substrate 3 (RAC3) OT2RE7A7 RAC3_HUMAN Affects Localization [31]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Decreases Expression [64]
Rho GTPase-activating protein 4 (ARHGAP4) OTXV053R RHG04_HUMAN Increases Expression [39]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Affects Localization [53]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [59]
Myosin light chain 5 (MYL5) OT7CQ24K MYL5_HUMAN Increases Expression [43]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Decreases Expression [39]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [34]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Expression [65]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [66]
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) OTYOORME NFAC3_HUMAN Decreases Localization [67]
Myosin-binding protein H (MYBPH) OTQJBPUR MYBPH_HUMAN Increases Expression [43]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [34]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [31]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Affects Localization [39]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [68]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Decreases Expression [66]
Interleukin-27 subunit alpha (IL27) OTIS3OF8 IL27A_HUMAN Increases Expression [32]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Phosphorylation [69]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Increases Expression [39]
Interleukin-17F (IL17F) OT9W9DE0 IL17F_HUMAN Decreases Secretion [68]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Decreases Expression [66]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Expression [70]
Podocin (NPHS2) OTLCNUII PODO_HUMAN Increases Expression [35]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Decreases Expression [32]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [31]
Dentin sialophosphoprotein (DSPP) OT1TYNDN DSPP_HUMAN Increases Expression [71]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Affects Expression [72]
CD2-associated protein (CD2AP) OTC76KQM CD2AP_HUMAN Increases Expression [35]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Affects Response To Substance [73]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Increases Response To Substance [74]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [75]
Small ribosomal subunit protein mS31 (MRPS31) OTB0OBWK RT31_HUMAN Decreases Response To Substance [76]
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) OTCVXOD6 SCAP_HUMAN Affects Response To Substance [77]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Increases ADR [78]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Response To Substance [76]
5-hydroxytryptamine receptor 3B (HTR3B) OTMGIYRE 5HT3B_HUMAN Increases Response To Substance [74]
ELL-associated factor 2 (EAF2) OTSOET5L EAF2_HUMAN Decreases Response To Substance [76]
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⏷ Show the Full List of 146 DOT(s)
Indication(s) of Atorvastatin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [4]
Angina pectoris BA40 Approved [4]
Arteriosclerosis BD40 Approved [4]
Cardiovascular disease BA00-BE2Z Approved [5]
Coronary atherosclerosis N.A. Approved [4]
Hypercholesterolaemia 5C80.0 Approved [4]
Hyperlipidemia 5C80.Z Approved [6]
Hyperlipidemia, familial combined, LPL related N.A. Approved [4]
Hypertriglyceridemia 5C80.1 Approved [4]
Inflammation 1A00-CA43.1 Approved [4]
Non-insulin dependent diabetes 5A11 Approved [4]
Psoriasis EA90 Approved [4]
Type-1/2 diabetes 5A10-5A11 Approved [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [7]
Stroke 8B20 Investigative [4]
Venous thromboembolism BD72 Investigative [4]
Atorvastatin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [11]
HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway) TTDJB68 N.A. Inhibitor [81]
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Atorvastatin Interacts with 7 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [82]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [83]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [84]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [85]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [86]
Monocarboxylate transporter 1 (SLC16A1) DT342ZG MOT1_HUMAN Substrate [87]
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [88]
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⏷ Show the Full List of 7 DTP(s)
Atorvastatin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [89]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [90]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [91]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [92]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [93]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [94]
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⏷ Show the Full List of 6 DME(s)
Atorvastatin Interacts with 47 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases ADR [22]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Increases Response To Substance [95]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [23]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [96]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [96]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [97]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [98]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Decreases Expression [98]
Hexokinase-4 (GCK) OTR3Q0NN HXK4_HUMAN Decreases Expression [98]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Activity [99]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [100]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Affects Expression [59]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [101]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [102]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [101]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Affects Expression [103]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [104]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Localization [105]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [106]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [54]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [54]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Decreases Expression [107]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Decreases Expression [108]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [59]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [106]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [106]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Decreases Expression [109]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [110]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [104]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [100]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [106]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [111]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Affects Localization [112]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [113]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [105]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [103]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [59]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Localization [114]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Activity [115]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [116]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Response To Substance [104]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [75]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [117]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Increases Uptake [118]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Transport [119]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Increases Uptake [118]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Affects Response To Substance [120]
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⏷ Show the Full List of 47 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Hypercholesterolemia DC6TWJR N. A. Phase 3 [121]
Hypercholesterolemia DCFE6EK N. A. Phase 1 [122]
Atherosclerosis DCJPS75 N. A. Phase 1 [123]
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121 ClinicalTrials.gov (NCT00664469) INdians Followed for INtensive Lipid Lowering Treatment and Its safetY
122 ClinicalTrials.gov (NCT02518516) High Potency Statins and Acute Kidney Injury
123 ClinicalTrials.gov (NCT00166530) EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)