Details of the Drug Combination

General Information of Drug Combination (ID: DCZTD9P)

Drug Combination Name

Azacitidine Mercaptopurine

Indication

Disease Entry	Status	REF
Childhood T acute lymphoblastic leukemia	Investigative	[1]

Component Drugs

Azacitidine DMTA5OE

Mercaptopurine DMTM2IK

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: CCRF-CEM

Zero Interaction Potency (ZIP) Score: 0.5

Bliss Independence Score: 1.79

Loewe Additivity Score: 0.63

LHighest Single Agent (HSA) Score: 4.07

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Azacitidine

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[2]
Chronic myelomonocytic leukemia	N.A.	Approved	[2]
Leukemia	N.A.	Approved	[2]
Myelodysplastic syndrome	2A37	Approved	[3]
Myeloproliferative neoplasm	2A20	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]

Azacitidine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[12]
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Azacitidine Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[13]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[14]
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Azacitidine Interacts with 275 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Affects Expression	[15]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[16]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Increases Expression	[16]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Expression	[16]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[16]
Sulfotransferase 1C2 (SULT1C2)	OT07MMZS	ST1C2_HUMAN	Increases Expression	[8]
Phospholipid phosphatase 1 (PLPP1)	OT0IIMI5	PLPP1_HUMAN	Increases Expression	[8]
Tectonin beta-propeller repeat-containing protein 2 (TECPR2)	OT1UFECZ	TCPR2_HUMAN	Increases Expression	[8]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Decreases Expression	[8]
Multiple epidermal growth factor-like domains protein 6 (MEGF6)	OTEUYTP1	MEGF6_HUMAN	Decreases Expression	[8]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Decreases Expression	[8]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Decreases Expression	[8]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[8]
Receptor-type tyrosine-protein phosphatase C (PTPRC)	OT6KOR77	PTPRC_HUMAN	Increases Expression	[8]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Decreases Expression	[8]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Increases Expression	[8]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[8]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1)	OT4L2SSB	GBRB1_HUMAN	Increases Expression	[8]
Transcription factor E3 (TFE3)	OTM99ZWH	TFE3_HUMAN	Increases Expression	[8]
Pro-thyrotropin-releasing hormone (TRH)	OT02UY2V	TRH_HUMAN	Decreases Expression	[8]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[8]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Increases Expression	[8]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	OTAG24N1	CDN2B_HUMAN	Decreases Methylation	[8]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)	OT729S0T	LIMS1_HUMAN	Increases Expression	[8]
E3 SUMO-protein ligase RanBP2 (RANBP2)	OTFG5CVF	RBP2_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Increases Expression	[8]
Ras-related protein Rab-13 (RAB13)	OTIQ484I	RAB13_HUMAN	Decreases Methylation	[8]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Increases Expression	[8]
Claudin-10 (CLDN10)	OT2CVAKY	CLD10_HUMAN	Decreases Expression	[8]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Decreases Expression	[8]
Protein delta homolog 1 (DLK1)	OTE1VLNB	DLK1_HUMAN	Decreases Methylation	[8]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[8]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Increases Expression	[8]
Equilibrative nucleoside transporter 2 (SLC29A2)	OTUAOB8T	S29A2_HUMAN	Decreases Expression	[8]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Increases Expression	[8]
C3a anaphylatoxin chemotactic receptor (C3AR1)	OT8J0TF8	C3AR_HUMAN	Increases Expression	[8]
DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F)	OT750IJM	ABC3F_HUMAN	Increases Expression	[8]
Angiogenic factor with G patch and FHA domains 1 (AGGF1)	OTA7U2T8	AGGF1_HUMAN	Increases Expression	[8]
E3 ubiquitin-protein ligase Praja-1 (PJA1)	OTFKTMEI	PJA1_HUMAN	Increases Expression	[8]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[8]
Tetraspanin-32 (TSPAN32)	OTSXW7EW	TSN32_HUMAN	Decreases Expression	[8]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Decreases Expression	[8]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Decreases Expression	[8]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)	OTVTB5R5	PI51A_HUMAN	Decreases Expression	[8]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Increases Expression	[8]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)	OTU230MC	ISCA1_HUMAN	Increases Expression	[8]
E3 ubiquitin-protein ligase TRIM8 (TRIM8)	OTS6JFR0	TRIM8_HUMAN	Increases Expression	[8]
Uncharacterized protein C6orf62 (C6ORF62)	OTGK4G35	CF062_HUMAN	Increases Expression	[8]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Decreases Expression	[8]
Pantothenate kinase 3 (PANK3)	OT77CFJ6	PANK3_HUMAN	Decreases Expression	[8]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)	OT410VP5	ABC3G_HUMAN	Increases Expression	[8]
Neuritin (NRN1)	OTWJG0SO	NRN1_HUMAN	Decreases Expression	[8]
NTF2-related export protein 2 (NXT2)	OTK82YVT	NXT2_HUMAN	Increases Expression	[8]
THUMP domain-containing protein 1 (THUMPD1)	OTKU8KWH	THUM1_HUMAN	Increases Expression	[8]
Protein FAM8A1 (FAM8A1)	OT1QVTGS	FA8A1_HUMAN	Increases Expression	[8]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)	OTB17Q43	SIA10_HUMAN	Increases Expression	[8]
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)	OTURGRA8	MSRB2_HUMAN	Increases Expression	[8]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)	OTJCX8K9	MD1L1_HUMAN	Decreases Expression	[8]
Signal-regulatory protein beta-1 (SIRPB1)	OTGHALWJ	SIRB1_HUMAN	Decreases Expression	[9]
Syntenin-1 (SDCBP)	OTS3NCC5	SDCB1_HUMAN	Decreases Expression	[9]
Complexin-1 (CPLX1)	OT7UIGTP	CPLX1_HUMAN	Increases Expression	[9]
Nephrocystin-1 (NPHP1)	OTZHCFFQ	NPHP1_HUMAN	Increases Expression	[9]
Phosphatase and actin regulator 2 (PHACTR2)	OTWMX2A8	PHAR2_HUMAN	Increases Expression	[9]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)	OT4TMERS	NFAC1_HUMAN	Increases Expression	[9]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Decreases Expression	[9]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[9]
Cystatin-C (CST3)	OTNZ6AO4	CYTC_HUMAN	Increases Expression	[9]
Cystatin-S (CST4)	OTXXM8EH	CYTS_HUMAN	Increases Expression	[9]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[9]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Decreases Expression	[9]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Increases Expression	[9]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[9]
Protein disulfide-isomerase (P4HB)	OTTYNYPF	PDIA1_HUMAN	Increases Expression	[9]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Expression	[9]
Profilin-1 (PFN1)	OTHTGA1H	PROF1_HUMAN	Increases Expression	[9]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Decreases Expression	[9]
Tropomyosin beta chain (TPM2)	OTA1L0P8	TPM2_HUMAN	Increases Expression	[9]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[9]
Keratin, type I cytoskeletal 19 (KRT19)	OTDGDQ75	K1C19_HUMAN	Increases Expression	[9]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Increases Expression	[9]
Small ribosomal subunit protein uS2 (RPSA)	OTJZHEGT	RSSA_HUMAN	Decreases Expression	[9]
Glycodelin (PAEP)	OTQA0NV4	PAEP_HUMAN	Decreases Expression	[9]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Increases Expression	[9]
Pregnancy-specific beta-1-glycoprotein 1 (PSG1)	OT1U4ZZW	PSG1_HUMAN	Increases Expression	[9]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[9]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[9]
Plastin-3 (PLS3)	OTYBM4PK	PLST_HUMAN	Decreases Expression	[9]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Decreases Expression	[9]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Increases Expression	[9]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[9]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Increases Expression	[9]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Decreases Expression	[9]
Desmin (DES)	OTI09KBW	DESM_HUMAN	Increases Expression	[9]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1)	OT5MXG9W	AT2B1_HUMAN	Decreases Expression	[9]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[9]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Increases Expression	[9]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Decreases Expression	[9]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[9]
Transcription elongation factor A protein 1 (TCEA1)	OTBFO594	TCEA1_HUMAN	Decreases Expression	[9]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[9]
Tenascin (TNC)	OTK4FSHR	TENA_HUMAN	Decreases Expression	[9]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)	OTKPL09B	VATL_HUMAN	Increases Expression	[9]
Protein ITPRID2 (ITPRID2)	OTO3JDX5	ITPI2_HUMAN	Increases Expression	[9]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[9]
Interleukin-12 subunit beta (IL12B)	OT0JF8A3	IL12B_HUMAN	Increases Expression	[9]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Decreases Expression	[9]
Guanylate-binding protein 2 (GBP2)	OTVU4G07	GBP2_HUMAN	Decreases Expression	[9]
MHC class II transactivator (CIITA)	OTRJNZFO	C2TA_HUMAN	Increases Expression	[9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[9]
Exosome RNA helicase MTR4 (MTREX)	OTSQY30V	MTREX_HUMAN	Increases Expression	[9]
Alpha-S1-casein (CSN1S1)	OTXOW6XJ	CASA1_HUMAN	Increases Expression	[9]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[9]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Increases Expression	[9]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)	OT6E2OW6	ENTP1_HUMAN	Increases Expression	[9]
Ephrin-A3 (EFNA3)	OTJGOUMZ	EFNA3_HUMAN	Increases Expression	[9]
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1)	OT7FBG5W	NAR1_HUMAN	Increases Expression	[9]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)	OTYHXLWZ	BCAT1_HUMAN	Decreases Expression	[9]
Microfibrillar-associated protein 2 (MFAP2)	OTMHVBTV	MFAP2_HUMAN	Decreases Expression	[9]
Laminin subunit beta-2 (LAMB2)	OT71OI2Y	LAMB2_HUMAN	Increases Expression	[9]
NHP2-like protein 1 (SNU13)	OTH56TIH	NH2L1_HUMAN	Increases Expression	[9]
Homeobox protein DLX-6 (DLX6)	OT0FIJHY	DLX6_HUMAN	Increases Expression	[9]
Neurotrypsin (PRSS12)	OT1MYL3L	NETR_HUMAN	Decreases Expression	[9]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Decreases Expression	[9]
Microtubule-associated protein 1A (MAP1A)	OTHO8K43	MAP1A_HUMAN	Decreases Expression	[9]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[9]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)	OTQR5SXD	CX6A2_HUMAN	Increases Expression	[9]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Decreases Expression	[9]
Caldesmon (CALD1)	OTNJKJ6Q	CALD1_HUMAN	Increases Expression	[9]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Decreases Expression	[9]
Serine/threonine-protein kinase PAK 1 (PAK1)	OT17LZNZ	PAK1_HUMAN	Increases Expression	[9]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)	OT6T408U	MP2K5_HUMAN	Decreases Expression	[9]
Chitotriosidase-1 (CHIT1)	OTPQR0A6	CHIT1_HUMAN	Increases Expression	[9]
Ras and Rab interactor 1 (RIN1)	OTPBROUD	RIN1_HUMAN	Increases Expression	[9]
Keratin, type I cuticular Ha2 (KRT32)	OTZCGZYT	K1H2_HUMAN	Increases Expression	[9]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Increases Expression	[9]
Ras GTPase-activating protein 3 (RASA3)	OT9C54MN	RASA3_HUMAN	Increases Expression	[9]
Mediator of DNA damage checkpoint protein 1 (MDC1)	OTEUQH4J	MDC1_HUMAN	Increases Expression	[9]
Transmembrane glycoprotein NMB (GPNMB)	OTB7KQKV	GPNMB_HUMAN	Decreases Expression	[9]
Mortality factor 4-like protein 2 (MORF4L2)	OT8OI3EC	MO4L2_HUMAN	Decreases Expression	[9]
kinase isozyme 1, mitochondrial (PDK1)	OTMABK9Z	PDK1_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Decreases Expression	[9]
Serine/threonine-protein phosphatase 2A activator (PTPA)	OTRGFOI7	PTPA_HUMAN	Increases Expression	[9]
Reticulocalbin-1 (RCN1)	OT3JBGAG	RCN1_HUMAN	Decreases Expression	[9]
Olfactory receptor 8B8 (OR8B8)	OTCISNYV	OR8B8_HUMAN	Increases Expression	[9]
Leukotriene B4 receptor 1 (LTB4R)	OT3SRH4H	LT4R1_HUMAN	Decreases Expression	[9]
Serine/arginine-rich splicing factor 7 (SRSF7)	OTRS4W4S	SRSF7_HUMAN	Decreases Expression	[9]
Guanylate kinase (GUK1)	OTLI0HRU	KGUA_HUMAN	Increases Expression	[9]
Filamin A-interacting protein 1-like (FILIP1L)	OTPY8IMS	FIL1L_HUMAN	Decreases Expression	[9]
Nucleolar MIF4G domain-containing protein 1 (NOM1)	OTWZSJJC	NOM1_HUMAN	Decreases Expression	[9]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA)	OTCPFOSA	MRCKA_HUMAN	Decreases Expression	[9]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Decreases Expression	[9]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Decreases Expression	[9]
Oxidation resistance protein 1 (OXR1)	OTPIDMT3	OXR1_HUMAN	Increases Expression	[9]
Alpha-2,8-sialyltransferase 8B (ST8SIA2)	OTRBBBD8	SIA8B_HUMAN	Decreases Expression	[9]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Expression	[9]
G-patch domain and KOW motifs-containing protein (GPKOW)	OTGS3H0M	GPKOW_HUMAN	Increases Expression	[9]
Rho guanine nucleotide exchange factor 2 (ARHGEF2)	OTBQTFRT	ARHG2_HUMAN	Decreases Expression	[9]
Homogentisate 1,2-dioxygenase (HGD)	OTTKLQOO	HGD_HUMAN	Increases Expression	[9]
Secretory carrier-associated membrane protein 4 (SCAMP4)	OTSCZTJ5	SCAM4_HUMAN	Increases Expression	[9]
Protein bicaudal D homolog 1 (BICD1)	OT78IYPF	BICD1_HUMAN	Decreases Expression	[9]
Ankyrin repeat and SOCS box protein 2 (ASB2)	OTF9LV7L	ASB2_HUMAN	Increases Expression	[9]
Eyes absent homolog 1 (EYA1)	OTHU807A	EYA1_HUMAN	Decreases Expression	[9]
Bcl-2-like protein 13 (BCL2L13)	OT2VRFTM	B2L13_HUMAN	Increases Expression	[9]
RNA helicase Mov10l1 (MOV10L1)	OTP978LK	M10L1_HUMAN	Increases Expression	[9]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Increases Expression	[9]
Ras-related protein Rab-1B (RAB1B)	OTAFCUAS	RAB1B_HUMAN	Increases Expression	[9]
Semaphorin-6C (SEMA6C)	OT1N59T5	SEM6C_HUMAN	Increases Expression	[9]
Sentrin-specific protease 3 (SENP3)	OTFQDOMC	SENP3_HUMAN	Increases Expression	[9]
Ribonuclease P protein subunit p21 (RPP21)	OT53MDNE	RPP21_HUMAN	Increases Expression	[9]
Protocadherin-18 (PCDH18)	OTTLQWRN	PCD18_HUMAN	Decreases Expression	[9]
Protein S100-A14 (S100A14)	OTVFJJ91	S10AE_HUMAN	Decreases Expression	[9]
Tryptase gamma (TPSG1)	OTDESHKT	TRYG1_HUMAN	Decreases Expression	[9]
Rho GTPase-activating protein 35 (ARHGAP35)	OTJ8POG0	RHG35_HUMAN	Increases Expression	[9]
Neuroligin-3 (NLGN3)	OTKDEC1Q	NLGN3_HUMAN	Increases Expression	[9]
Polycystin-2-like protein 1 (PKD2L1)	OT1KJDAT	PK2L1_HUMAN	Increases Expression	[9]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Decreases Expression	[9]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1)	OT64TTGC	PITC1_HUMAN	Decreases Expression	[9]
Transcription factor SOX-13 (SOX13)	OTCIF6KC	SOX13_HUMAN	Decreases Expression	[9]
Afadin- and alpha-actinin-binding protein (SSX2IP)	OTEIZ7N1	ADIP_HUMAN	Increases Expression	[9]
Transmembrane emp24 domain-containing protein 3 (TMED3)	OTNOPHHC	TMED3_HUMAN	Increases Expression	[9]
Protocadherin beta-4 (PCDHB4)	OTF665E0	PCDB4_HUMAN	Decreases Expression	[9]
Protocadherin beta-14 (PCDHB14)	OTFZF1ST	PCDBE_HUMAN	Decreases Expression	[9]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Increases Expression	[9]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Increases Expression	[17]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Increases Expression	[17]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[17]
Tyrosine aminotransferase (TAT)	OT2CJ91O	ATTY_HUMAN	Increases Expression	[17]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Increases Expression	[17]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[17]
Hematopoietically-expressed homeobox protein HHEX (HHEX)	OTLIUVYX	HHEX_HUMAN	Increases Expression	[17]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Affects Expression	[15]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Expression	[18]
Aquaporin-9 (AQP9)	OTLGH5ZY	AQP9_HUMAN	Increases Expression	[19]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7)	OTHS1L0E	GBG7_HUMAN	Affects Methylation	[20]
Claudin-7 (CLDN7)	OTNE0XHQ	CLD7_HUMAN	Decreases Expression	[21]
Claudin-9 (CLDN9)	OTCKI2IZ	CLD9_HUMAN	Increases Expression	[22]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[18]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Decreases Methylation	[23]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Response To Substance	[24]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Expression	[25]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Affects Activity	[26]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Affects Methylation	[27]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Affects Methylation	[27]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Expression	[28]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[29]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Increases Expression	[30]
Thyroid peroxidase (TPO)	OTJJLL20	PERT_HUMAN	Increases Expression	[31]
Prostate-specific antigen (KLK3)	OTFGSBFJ	KLK3_HUMAN	Increases Expression	[29]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Increases Expression	[32]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Affects Expression	[15]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Decreases Expression	[33]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Increases Expression	[29]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Decreases Expression	[34]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Decreases Expression	[33]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[29]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[35]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[33]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Decreases Methylation	[36]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[37]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Increases Expression	[38]
Thyrotropin receptor (TSHR)	OT0BC8LB	TSHR_HUMAN	Increases Expression	[31]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Increases Expression	[19]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[28]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[39]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[29]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Decreases Expression	[40]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Affects Methylation	[41]
Oxytocin receptor (OXTR)	OT7WFW4U	OXYR_HUMAN	Decreases Expression	[28]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Affects Expression	[15]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Methylation	[42]
Melanoma-associated antigen 1 (MAGEA1)	OTXAO193	MAGA1_HUMAN	Decreases Methylation	[42]
Melanoma-associated antigen 3 (MAGEA3)	OTW3Y5M4	MAGA3_HUMAN	Increases Expression	[43]
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1)	OTL1LBQJ	KI2L1_HUMAN	Increases Expression	[44]
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2)	OTOVUTJD	KI2L2_HUMAN	Increases Expression	[44]
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)	OTFCN53B	KI2L3_HUMAN	Increases Expression	[44]
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)	OTPOSXFX	KI3L1_HUMAN	Increases Expression	[44]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)	OT00N6UJ	KI2S4_HUMAN	Increases Expression	[44]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Response To Substance	[24]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Increases Expression	[45]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Increases Expression	[46]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Response To Substance	[24]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Increases Expression	[28]
Homeobox protein Nkx-2.5 (NKX2-5)	OTS1SAWM	NKX25_HUMAN	Increases Expression	[47]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Affects Methylation	[48]
Claudin-6 (CLDN6)	OTEN8ID2	CLD6_HUMAN	Increases Expression	[22]
Claudin-8 (CLDN8)	OT7IIWXG	CLD8_HUMAN	Increases Expression	[22]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[28]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	OT83PT85	PP2AA_HUMAN	Increases Expression	[49]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Decreases Expression	[50]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Decreases Activity	[51]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[15]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Increases Expression	[22]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Decreases Methylation	[52]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[53]
N-myc-interactor (NMI)	OTYVG3NM	NMI_HUMAN	Increases Expression	[28]
NAD(P) transhydrogenase, mitochondrial (NNT)	OTAIOGZK	NNTM_HUMAN	Increases Expression	[21]
Runt-related transcription factor 3 (RUNX3)	OTITK1XD	RUNX3_HUMAN	Affects Methylation	[54]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[55]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Decreases Expression	[28]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Increases Expression	[22]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Decreases Methylation	[56]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[28]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[57]
Sodium/iodide cotransporter (SLC5A5)	OTU7E9G7	SC5A5_HUMAN	Increases Expression	[58]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[28]
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)	OTXN18OA	KI2L4_HUMAN	Increases Expression	[44]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[28]
Calcium homeostasis modulator protein 2 (CALHM2)	OTWWM6HI	CAHM2_HUMAN	Increases Expression	[21]
Homeobox protein SIX2 (SIX2)	OTYOVGSC	SIX2_HUMAN	Decreases Expression	[21]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Increases Expression	[59]
Sal-like protein 4 (SALL4)	OTC08PR5	SALL4_HUMAN	Affects Methylation	[11]
Transcription factor MafB (MAFB)	OTH2N3T8	MAFB_HUMAN	Increases Expression	[21]
Sodium/nucleoside cotransporter 1 (SLC28A1)	OTXWVV9O	S28A1_HUMAN	Increases Response To Substance	[60]
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⏷ Show the Full List of 275 DOT(s)

Indication(s) of Mercaptopurine

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Approved	[4]
Acute lymphocytic leukaemia	2B33.3	Approved	[5]
Crohn disease	DD70	Phase 4	[6]
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[7]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[7]

Mercaptopurine Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
MERS-CoV papain-like proteinase (PL-PRO)	TTYJOLE	R1AB_CVEMC (854-2740)	Inhibitor	[7]
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	TTL7C8Q	IMDH1_HUMAN	Inhibitor	[63]
SARS-CoV papain-like proteinase (PL-PRO)	TTRGHB2	R1AB_CVHSA (819-2740)	Inhibitor	[7]
Amidophosphoribosyltransferase (PPAT)	TTZFTY4	PUR1_HUMAN	Breaker	[64]
------------------------------------------------------------------------------------

Mercaptopurine Interacts with 9 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[65]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[66]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[67]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[68]
Concentrative nucleoside transporter 2 (SLC28A2)	DT82KPY	S28A2_HUMAN	Substrate	[69]
Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)	DT4YL5R	S28A3_HUMAN	Substrate	[70]
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[69]
Equilibrative nucleoside transporter 2 (SLC29A2)	DTW78DQ	S29A2_HUMAN	Substrate	[69]
Equilibrative nucleobase transporter 1 (SLC43A3)	DTGBPR5	S43A3_HUMAN	Substrate	[71]
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⏷ Show the Full List of 9 DTP(s)

Mercaptopurine Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[72]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[72]
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Metabolism	[73]
------------------------------------------------------------------------------------

Mercaptopurine Interacts with 20 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Thiopurine S-methyltransferase (TPMT)	OTFOX70W	TPMT_HUMAN	Affects Response To Substance	[74]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Increases ADR	[75]
Thiopurine S-methyltransferase (TPMT)	OTFOX70W	TPMT_HUMAN	Decreases Metabolism	[76]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[77]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	OTPG0K7E	IMDH2_HUMAN	Increases Expression	[77]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Increases Expression	[77]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[77]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Increases Expression	[77]
Glutathione synthetase (GSS)	OTVSBEIW	GSHB_HUMAN	Increases Expression	[77]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Affects Localization	[78]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Affects Activity	[26]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Decreases Phosphorylation	[61]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[61]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[61]
Molybdenum cofactor sulfurase (MOCOS)	OT0TL3Q5	MOCOS_HUMAN	Decreases Oxidation	[79]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)	OTC6GISG	DQA1_HUMAN	Affects Response To Substance	[80]
Major vault protein (MVP)	OTJGHJRB	MVP_HUMAN	Decreases Response To Substance	[81]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Affects Response To Substance	[80]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Affects Response To Substance	[62]
Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)	OTX8SZOT	NUD15_HUMAN	Increases Response To Substance	[82]
------------------------------------------------------------------------------------


⏷ Show the Full List of 20 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCCPGG6	HT29	Investigative	[1]
Large cell lung carcinoma	DCAAA2G	NCI-H460	Investigative	[1]
Plasma cell myeloma	DCJ4K0I	RPMI-8226	Investigative	[1]
------------------------------------------------------------------------------------

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