Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM04LR2)

Drug Name
Floxuridine Drug Info
Synonyms
floxuridine; 50-91-9; 2'-Deoxy-5-fluorouridine; 5-Fluorodeoxyuridine; Fluorodeoxyuridine; Floxuridin; FUDR; Fluoruridine deoxyribose; Deoxyfluorouridine; 5-Fluoro-2'-deoxyuridine; FdUrd; Floxuridinum; Floxiridina; 5FdU; 5-fluoro-1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione; 5-Fluoro-2-desoxyuridine; 5 Fluorodeoxyuridine; Floxuridinum [INN-Latin]; FDUR; Floxiridina [INN-Spanish]; beta-5-Fluoro-2'-deoxyuridine; 5-Fluoro-2-deoxyuridine; 5-FdUrd; 5-Fluorouracil deoxyriboside; Sterile fudr (TN); Floxuridine/5-fluorouracil
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Approved [1]
Liver cancer 2C12 Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Colon cancer 2B90.Z Investigative [2]
Gastric cancer 2B72 Investigative [2]
Cross-matching ID
PubChem CID
5790
ChEBI ID
CHEMBL917
CAS Number
CAS 50-91-9
TTD Drug ID
DM04LR2
VARIDT Drug ID
DR00682
INTEDE Drug ID
DR1754

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Candida Thymidylate synthase (Candi TMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [15]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [16]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [17]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [18]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [19]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [20]
Flucytosine DM13VTW Cryptococcal meningitis Approved [21]
Nolatrexed DMOF0CA Solid tumour/cancer 2A00-2F9Z Phase 3 [22]
Plevitrexed (R)-isomer DMTL39C Gastric adenocarcinoma 2B72 Phase 2 [23]
Plevitrexed DM7Y60I Gastric adenocarcinoma 2B72 Phase 2 [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [25]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [26]
Deoxythymidine DMR90HY Discovery agent N.A. Investigative [27]
Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [35]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [36]
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Drug(s) Affected By Thymidine kinase, cytosolic (TK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [39]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
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Drug(s) Affected By Trifunctional purine biosynthetic protein adenosine-3 (GART)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Clozapine DMFC71L Schizophrenia 6A20 Approved [51]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [55]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [57]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [56]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
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Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [62]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [63]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [66]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [67]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [68]
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Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [69]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
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Drug(s) Affected By C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [81]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [64]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [82]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
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Drug(s) Affected By Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Ethanol DMDRQZU Chronic pain MG30 Approved [84]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [81]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [85]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [86]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) Main DME DE4HCYL TYPH_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) OTMKHVWC C1TC_HUMAN Drug Response [6]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Drug Response [7]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Drug Response [8]
DNA repair protein XRCC1 OTWRV4S2 XRCC1_HUMAN Drug Response [9]
DNA repair protein XRCC4 OT4SXOIZ XRCC4_HUMAN Drug Response [10]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Drug Response [11]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Drug Response [9]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Gene/Protein Processing [12]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Gene/Protein Processing [13]
Thymidylate synthase OTXTG0C7 TYSY_HUMAN Drug Response [14]

References

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2 Floxuridine FDA Label
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71 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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73 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
74 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
75 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
76 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
77 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
78 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
79 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
80 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
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