Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM40EF6)

• Drug Name: Penicillamine Drug Info
• Synonyms: D-Penicillamine; penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine; 3-Mercapto-D-valine; Depen; Cuprenil; D-Penamine; (-)-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; D-Mercaptovaline; Mercaptovaline; Perdolat; Penicillamin; Pendramine; Kuprenil; Depamine; Mercaptyl; Trolovol; Metalcaptase; Artamine; Cupripen; (S)-3,3-Dimethylcysteine; D-Valine, 3-mercapto-; Penicillaminum; Penicilamina; Sufirtan; beta-Thiovaline; Dimethylcysteine; D-beta,beta-Dimethylcysteine; D-3-Mercaptovaline; beta,beta-Dimethylcysteine; Penicillamina; Penicilllamine; Sufortan; Copper penicillaminate; D Penicillamine; Penicillamina [DCIT]; Reduced penicillamine; D 3 Mercaptovaline; TBB068824; Beta,beta Dimethylcysteine; Beta-Thiovaline; Cuprimine (TN); D-Penicilamine; D-Penicyllamine; Depen (TN); P-1280; Penicilamina [INN-Spanish]; Penicillaminate, Copper; Penicillaminum [INN-Latin]; Reduced D-penicillamine; Beta,beta-Dimethylcysteine; D,3-Mercaptovaline; D-beta-Mercaptovaline; Distamine (*Hydrochloride*); Metalcaptase (*Hydrochloride*); Penicillamine (JAN/USP/INN); Penicillamine [USAN:INN:BAN:JAN]; Alpha-Amino-beta-methyl-beta-mercaptobutyric acid; D-(-)-2-Amino-3-mercapto-3-methylbutanoic acid; (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid; (D)-PENICILLAMINE; (S)-Penicillamin; (S)-Penicillamine; 2-Amino-3-mercapto-3-methylbutanoic acid; 3,3-Dimethyl-D-cysteine; 3-Mercaptovaline; 3-sulfanyl-D-valine; D-penicillamine

Indication

Disease Entry	ICD 11	Status	REF
Cystinuria	5C60.2	Approved	[1]
Rheumatoid arthritis	FA20	Approved	[2]
Wilson disease	5C64.00	Investigative	[1]

• Therapeutic Class: Antidotes
• Cross-matching ID:
  PubChem CID: 5852
  ChEBI ID: CHEBI:7959
  CAS Number: CAS 771431-20-0
  TTD Drug ID: DM40EF6
  ACDINA Drug ID: D00514

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Tat protein (HIV tat)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ro-24-7429	DMA2UYE	Human immunodeficiency virus infection	1C62	Phase 2	[9]
ALX-40-4C	DMV934L	Human immunodeficiency virus infection	1C62	Phase 2	[10]
Anti-HIV ribozyme therapy	DMQZJ3B	Human immunodeficiency virus infection	1C62	Phase 1/2	[11]
EM-2487	DMG9R8E	Human immunodeficiency virus infection	1C62	Terminated	[12]
Durhamycin A	DM29PTO	Discovery agent	N.A.	Investigative	[13]
CGP 40336A	DMEA5BZ	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By Elastin (ELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[17]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[18]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[19]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[22]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[23]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[24]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[26]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[30]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[34]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[35]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[27]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[38]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[45]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[46]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[54]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[55]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[60]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[61]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[62]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[68]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[69]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[70]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[71]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[72]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[23]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[77]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[84]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[85]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[86]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[89]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[100]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[101]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[102]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[101]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[114]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[115]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[115]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[111]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[115]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[116]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[119]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[120]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[123]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[115]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[115]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[144]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[147]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[149]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]

Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[164]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[165]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[166]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Indomethacin	DMSC4A7	Bursitis		Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[173]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[78]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[174]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[176]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]

Drug(s) Affected By Flavin-containing monooxygenase 5 (FMO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[179]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[179]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[164]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]

Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[188]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[187]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[22]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[190]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[27]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[195]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[203]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[204]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[100]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[208]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[209]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[211]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[213]
Bortezomib	DMNO38U	Leukemia		Approved	[214]

Drug(s) Affected By Haptoglobin (HP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[221]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[225]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[226]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[227]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[228]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[229]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[23]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[230]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[34]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[232]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[233]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[234]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[235]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[236]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[240]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[241]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[23]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[243]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[246]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[247]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[251]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[252]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[253]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[110]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[176]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[259]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[262]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[54]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[263]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[264]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[266]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[268]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[141]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[269]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[5]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[5]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[5]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[5]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[5]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[5]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[5]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[5]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[5]

Drug(s) Affected By Lysyl oxidase homolog 2 (LOXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[219]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[271]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[272]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[273]

Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[274]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[275]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[276]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[277]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[278]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[279]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[280]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[280]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[281]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[275]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[283]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[280]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[284]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[285]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[278]

Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[280]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[280]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[286]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[280]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[287]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[288]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[289]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Tat protein (HIV tat)	TTT3ZC9	TAT_HV1H2	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Biochemical Pathways	[4]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Gene/Protein Processing	[6]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[8]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[6]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[6]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7264).
• [3] Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1. FEBS Lett. 2002 Apr 10;516(1-3):43-6.
• [4] Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
• [5] Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
• [6] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [7] The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):286-97. doi: 10.1185/03007997509114779.
• [8] N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway. Mol Carcinog. 2010 Jan;49(1):68-74. doi: 10.1002/mc.20578.
• [9] A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52.
• [10] Anti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactions. J Virol. 1996 May;70(5):2825-31.
• [11] Clinical gene therapy research utilizing ribozymes: application to the treatment of HIV/AIDS. Methods Mol Biol. 2004;252:581-98.
• [12] EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation. J Antibiot (Tokyo). 1999 Nov;52(11):971-82.
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