Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4DG1Y)

Drug Name
naringin Drug Info
Synonyms Naringoside; AC1NR4U8; 4',5,7-Trihydroxyflavanone-7-rutinoside; 4',5,7-Trihydroxyflavanone-7-rhamnoglucoside
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
442428
ChEBI ID
CHEMBL451532
CAS Number
CAS 10236-47-2
TTD Drug ID
DM4DG1Y
VARIDT Drug ID
DR00581

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Investigative Drug(s)
Preclinical Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium-independent organic anion transporter (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [10]
Drug(s) Metabolized By Alpha-L-rhamnosidase (lrA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HY-N2258 DML4IAX N. A. N. A. Preclinical [3]
Rutin DMEHRAJ Discovery agent N.A. Investigative [3]
Ginsenoside Re DM46FVD N. A. N. A. Investigative [3]
PNA-l-rhamnopyranoside DMZF7RQ N. A. N. A. Investigative [3]
Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [15]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [16]
Pamidronate DMB4AVP Bone Paget disease Approved [17]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [18]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [26]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [27]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [28]
Testosterone DM7HUNW Hot flushes GA30 Approved [29]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [30]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Epinephrine DM3KJBC Acute asthma CA23 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Fructose DM43AN2 Vomiting MD90 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [39]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [50]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [51]
Paclitaxel DMLB81S Breast carcinoma Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [44]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [61]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [64]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [68]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Etretinate DM2CZFA Keratosis ED56 Approved [70]
Prednisone DM2HG4X Acute asthma CA23 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
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Drug(s) Affected By FAS-associated death domain protein (FADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [75]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [78]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [83]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium-independent organic anion transporter (SLCO1A2) TTUGD21 SO1A2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alpha-L-rhamnosidase (lrA) Main DME DEBI82Z A0A1V8Q7P3_9BIF Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [7]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Gene/Protein Processing [8]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Post-Translational Modifications [5]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Gene/Protein Processing [6]
Vascular cell adhesion protein 1 OTP74K37 VCAM1_HUMAN Gene/Protein Processing [9]

References

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2 Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther. 2007 Apr;81(4):495-502.
3 Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25.
4 Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells. J Tissue Eng Regen Med. 2017 Jan;11(1):276-284. doi: 10.1002/term.1911. Epub 2014 Jun 11.
5 Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis. 2008 Sep;29(9):1701-9. doi: 10.1093/carcin/bgn055. Epub 2008 Feb 22.
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7 Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma. Chem Biol Interact. 2016 Jan 25;244:195-203. doi: 10.1016/j.cbi.2015.12.011. Epub 2015 Dec 22.
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32 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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67 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
68 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
69 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
70 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
71 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
72 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
73 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
74 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
75 Doxorubicin and selenium cooperatively induce fas signaling in the absence of Fas/Fas ligand interaction. Anticancer Res. 2007 Sep-Oct;27(5A):3075-82.
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77 The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
78 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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