Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4SOAW)

Drug Name
URSOLIC ACID Drug Info
Synonyms
Ursolic acid; Prunol; Malol; Urson; 77-52-1; 3beta-Hydroxyurs-12-en-28-oic acid; (3beta)-3-Hydroxyurs-12-en-28-oic acid; 3beta-Hydroxy-12-ursen-28-ic acid; UNII-P3M2575F3F; CHEBI:9908; CCRIS 7123; EINECS 201-034-0; CHEMBL169; Merotaine; AI3-03109; NSC4060; P3M2575F3F; NSC-4060; Urs-12-en-28-oic acid, 3-hydroxy-, (3beta)-; HNMR; .beta.-Ursolic acid; NSC 4060; NSC 167406
Indication
Disease Entry ICD 11 Status REF
Metabolic syndrome x 5C50-5D2Z Phase 2 [1]
Cross-matching ID
PubChem CID
64945
ChEBI ID
CHEMBL169
CAS Number
CAS 77-52-1
TTD Drug ID
DM4SOAW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phospholipase A2 (PLA2G1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [12]
Miltefosine DMND304 Chronic urticaria Approved [13]
Clocortolone DM9ZMQH Exanthem Approved [14]
Clobetasol DMUXP52 Rosacea ED90.0 Approved [15]
Diflorasone DMI9PRJ Exanthem Approved [16]
AllerB DM78DOT Allergy 4A80-4A85 Phase 2b [17]
MANOALIDE DMB4A8I Arthritis FA20 Phase 2 [18]
MRX-4 DMQZWYE Allergic rhinitis CA08.0 Phase 2 [19]
MRX-6 DMLVQKF Contact dermatitis EK0Z Phase 2 [20]
Varespladib DM5JJ83 Snakebite N.A. Phase 2 [21]
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Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [22]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [23]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [24]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [25]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [23]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [26]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [27]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [28]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [23]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [26]
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Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GLYCYRRHIZIN DM8M2N3 Influenza virus infection 1E30-1E32 Phase 3 [29]
BVT.2733 DM6RUKX Lupus 4A40 Phase 3 [30]
INCB13739 DMLQ3PO Type-2 diabetes 5A11 Phase 2a [31]
JTT-654 DM50M2R Type-2 diabetes 5A11 Phase 2 [32]
RG-4929 DMT4QRD Metabolic disorder 5C50-5D2Z Phase 2 [32]
BMS-770767 DMTVGY7 Hypercholesterolaemia 5C80.0 Phase 2 [32]
UE-2343 DMIERPK Alzheimer disease 8A20 Phase 2 [33]
AZD-4017 DML9M5S Ocular hypertension 9C61.01 Phase 2 [32]
Xanamem DM580GT Alzheimer disease 8A20 Phase 1/2 [34]
BMS-816336 DM2WMJ7 Lipid metabolism disorder 5C52.Z Phase 1 [35]
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Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [37]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [38]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [39]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [40]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [12]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [12]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [12]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [12]
1,2-NAPHTHOQUINONE DMYXELH Discovery agent N.A. Investigative [41]
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Drug(s) Targeting Glycogen phosphorylase muscle form (GP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
JTT-651 DMGP42Q Type-2 diabetes 5A11 Discontinued in Phase 1 [42]
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [12]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [12]
Indirubin-5-sulfonate DM08VHZ Discovery agent N.A. Investigative [12]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [12]
Alpha-D-Glucose-6-Phosphate DMR0EVN Discovery agent N.A. Investigative [12]
N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO Discovery agent N.A. Investigative [12]
OLEANOLIC_ACID DMWDMJ3 Discovery agent N.A. Investigative [43]
Oleanonic acid DMYPJC3 Discovery agent N.A. Investigative [43]
Nojirimycine Tetrazole DMYZRTB Discovery agent N.A. Investigative [44]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [46]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [47]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [48]
Capsaicin DMGMF6V Back pain ME84.Z Approved [49]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [50]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [51]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [50]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [46]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [52]
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Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [59]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [60]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [56]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [65]
Prednisone DM2HG4X Acute asthma CA23 Approved [66]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [73]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [59]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [76]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [77]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [78]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [79]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [80]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [81]
Cepharanthine DM9Y5JB N. A. N. A. Approved [82]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [83]
Clozapine DMFC71L Schizophrenia 6A20 Approved [84]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [85]
Trifluoperazine DMKBYWI Anxiety Approved [86]
Olanzapine DMPFN6Y Bipolar depression Approved [84]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [91]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [107]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [108]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [115]
Gefitinib DM15F0X Colon adenocarcinoma Approved [116]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Etretinate DM2CZFA Keratosis ED56 Approved [118]
Prednisone DM2HG4X Acute asthma CA23 Approved [119]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [120]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Prednisone DM2HG4X Acute asthma CA23 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [122]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [123]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Fluoxetine DM3PD2C Bipolar depression Approved [126]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [130]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [135]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [137]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [139]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [143]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [144]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [148]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [149]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [150]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [151]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [159]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [160]
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Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [162]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [59]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [60]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [163]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [166]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [168]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [170]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [2]
Glycogen phosphorylase muscle form (GP) TTZHY6R PYGM_HUMAN Inhibitor [3]
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [4]
Phospholipase A2 (PLA2G1B) TT9V5JH PA21B_HUMAN Inhibitor [5]
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Post-Translational Modifications [7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Drug Response [8]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [9]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [7]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [7]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [10]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [11]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [7]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Post-Translational Modifications [7]

References

1 ClinicalTrials.gov (NCT02337933) Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome. U.S. National Institutes of Health.
2 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
3 Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
4 DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod. 1999 Dec;62(12):1624-6.
5 Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.
6 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
7 Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress. Chem Biol Interact. 2014 Jul 25;218:28-41. doi: 10.1016/j.cbi.2014.04.017. Epub 2014 May 5.
8 Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. Cancer Lett. 2010 Dec 1;298(1):128-38. doi: 10.1016/j.canlet.2010.06.010. Epub 2010 Jul 13.
9 Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus. Environ Toxicol. 2021 Feb;36(2):267-275. doi: 10.1002/tox.23032. Epub 2020 Oct 3.
10 Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells. Oncol Rep. 2005 Aug;14(2):507-12.
11 Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. Life Sci. 2004 Apr 16;74(22):2769-79.
12 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
13 Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.
14 Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis. Cutis. 1980 Jan;25(1):96-8.
15 Utilization of epidermal phospholipase A2 inhibition to monitor topical steroid action. Br J Dermatol. 1984 Jul;111 Suppl 27:195-203.
16 Structures from powders: diflorasone diacetate. Steroids. 2009 Jan;74(1):102-11.
17 Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):747-54.
18 Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat. Neurochem Res. 1998 Oct;23(10):1251-7.
19 Phospholipase A2, group IVA (cytosolic, calcium-dependent) (PLA2G4A). SciBX 1(41); doi:10.1038/scibx.2008.999. Nov. 13 2008
20 A novel treatment of contact dermatitis by topical application of phospholipase A2 inhibitor: a double-blind placebo-controlled pilot study. Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1):191-5.
21 Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes. Toxins (Basel). 2022 Nov 11;14(11):783.
22 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
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