Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM78XFG)

Drug Name
Tibolone Drug Info
Synonyms Livial (TN)
Indication
Disease Entry ICD 11 Status REF
Anabolic metabolism 5C50-5C8Z Approved [1]
Cross-matching ID
PubChem CID
444008
ChEBI ID
CHEMBL2103774
CAS Number
CAS 5630-53-5
TTD Drug ID
DM78XFG
INTEDE Drug ID
DR1590

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [8]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [9]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [10]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [12]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [13]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [14]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [15]
Epinephrine DM3KJBC Acute asthma CA23 Approved [16]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [17]
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Drug(s) Metabolized By Dihydrotestosterone oxidoreductase (HSD3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [19]
HE2100 DMCP2KH Thrombocytopenia 3B64 Discontinued in Phase 1 [20]
17alpha-hydroxypregnenolone DMT2EPG Discovery agent N.A. Investigative [19]
Drug(s) Metabolized By Beta-HSD adrenal and gonadal type (HSD3B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [21]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [19]
17alpha-hydroxypregnenolone DMT2EPG Discovery agent N.A. Investigative [19]
Drug(s) Affected By Protein-tyrosine sulfotransferase 1 (TPST1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [25]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [26]
Urethane DM7NSI0 N. A. N. A. Phase 4 [27]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [28]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [29]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [30]
Milchsaure DM462BT Pruritus EC90 Investigative [31]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [32]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [33]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [37]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [38]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [41]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [62]
Paclitaxel DMLB81S Breast carcinoma Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
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Drug(s) Affected By Transcription factor 7 (TCF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [68]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [69]
Bortezomib DMNO38U Leukemia Approved [70]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [71]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [72]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [67]
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Drug(s) Affected By Interleukin-13 receptor subunit alpha-1 (IL13RA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [76]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [71]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Testosterone enanthate DMB6871 N. A. N. A. Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [86]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [87]
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Drug(s) Affected By Protein phosphatase Mn(2+)-dependent 1K (PPM1K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Folic Acid DMEMBJC Colorectal carcinoma Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [93]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [94]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [95]
Urethane DM7NSI0 N. A. N. A. Phase 4 [27]
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Drug(s) Affected By Stromal membrane-associated protein 2 (SMAP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [98]
Urethane DM7NSI0 N. A. N. A. Phase 4 [27]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [99]
Milchsaure DM462BT Pruritus EC90 Investigative [31]
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Drug(s) Affected By C-type lectin domain family 4 member E (CLEC4E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [101]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [71]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [102]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [103]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [104]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [105]
desmosterol DMV8SUM Discovery agent N.A. Investigative [102]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-HSD adrenal and gonadal type (HSD3B2) DEN0GVQ 3BHS2_HUMAN Substrate [2]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [3]
Dihydrotestosterone oxidoreductase (HSD3B1) DERDQWN 3BHS1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [4]
C-type lectin domain family 4 member E (CLEC4E) OT7P8ICY CLC4E_HUMAN Gene/Protein Processing [5]
Interleukin-13 receptor subunit alpha-1 (IL13RA1) OT59OYXP I13R1_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Gene/Protein Processing [5]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Gene/Protein Processing [7]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K) OTNZ4N4E PPM1K_HUMAN Gene/Protein Processing [5]
Protein-tyrosine sulfotransferase 1 (TPST1) OTDPQKEA TPST1_HUMAN Gene/Protein Processing [5]
Stromal membrane-associated protein 2 (SMAP2) OTPGVRKO SMAP2_HUMAN Gene/Protein Processing [5]

References

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3 Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
4 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
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6 Tibolone and its metabolites induce antimitogenesis in human coronary artery smooth muscle cells: role of estrogen, progesterone, and androgen receptors. J Clin Endocrinol Metab. 2004 Feb;89(2):852-9. doi: 10.1210/jc.2003-031272.
7 Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects. Steroids. 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010.
8 Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
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23 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
24 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
25 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
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29 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
30 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
31 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
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36 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
37 Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
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39 Intractable insomnia after cessation of treatment with thalidomide. Gastroenterology. 2001 May;120(6):1567-8. doi: 10.1053/gast.2001.24495.
40 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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49 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
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51 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
52 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
53 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
54 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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60 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
61 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
62 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
63 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
64 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
65 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
66 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
67 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
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