Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7P3IZ)

Drug Name
3-aminobenzamide Drug Info
Synonyms
3-Aminobenzamide; 3544-24-9; m-Aminobenzamide; Benzamide, 3-amino-; 3-Amino-benzamide; Benzamide, m-amino-; meta-aminobenzamide; 3-ABA; 3-Aminobenzimide; 3-amino benzamide; aniline-3-carboxamide; 3-aminobenzoic acid amide; UNII-8J365YF1YH; CCRIS 3925; EINECS 222-586-9; NSC 36962; BRN 2802373; PARP Inhibitor I, 3-ABA; 3-H2NC6H4CONH2; CHEMBL81977; 3-AB; 8J365YF1YH; CHEBI:64042; GSCPDZHWVNUUFI-UHFFFAOYSA-N; MFCD00007989; 3-Aminobenzamide, 98%; SR-01000075657; HSDB 7581; 3-azanylbenzamide; m-amino benzamide; 4pml; 3-Aminobenzaminde
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1645
ChEBI ID
CHEMBL81977
CAS Number
CAS 3544-24-9
TTD Drug ID
DM7P3IZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Poly [ADP-ribose] polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [6]
KU-0058948 DMSA4HZ Ovarian cancer 2C73 Approved [7]
Niraparib Tosylate DMLPSWQ Fallopian tube cancer 2C74 Approved [8]
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [9]
Nicaraven DMFBNA3 Cerebrovascular disease 8B2Z Phase 3 [10]
PMID27841036-Compound-37 DM0OVZ2 Ovarian cancer 2C73 Phase 2 [11]
Stenoparib DMKVBL8 Ovarian cancer 2C73 Phase 2 [12]
AG140699 DMA9FKY Melanoma 2C30 Phase 2 [13]
AZD5305 DMW9R1C Prostate cancer 2C82.0 Phase 2 [14]
AMXI 5001 DMR9H6B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [15]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [22]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [23]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [31]
Pamidronate DMB4AVP Bone Paget disease Approved [32]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Fructose DM43AN2 Vomiting MD90 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
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Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [49]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [50]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [53]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Testosterone DM7HUNW Hot flushes GA30 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Etretinate DM2CZFA Keratosis ED56 Approved [68]
Prednisone DM2HG4X Acute asthma CA23 Approved [69]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [70]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [71]
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Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [73]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [76]
Arsenic DMTL2Y1 N. A. N. A. Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [79]
Bortezomib DMNO38U Leukemia Approved [80]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
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Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [84]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [83]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
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Drug(s) Affected By Poly polymerase 2 (PARP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Leflunomide DMR8ONJ Arthritis FA20 Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [95]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase 1 (PARP1) TTVDSZ0 PARP1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [2]
Chimeric ERCC6-PGBD3 protein (ERCC6) OT2QZKSF ERPG3_HUMAN Drug Response [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [2]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Gene/Protein Processing [4]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Gene/Protein Processing [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [2]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Gene/Protein Processing [2]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Drug Response [5]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Gene/Protein Processing [2]

References

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64 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
65 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
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67 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
68 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
69 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
70 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
71 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
72 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
73 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
74 Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One. 2013 Oct 4;8(10):e75905. doi: 10.1371/journal.pone.0075905. eCollection 2013.
75 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
76 Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene. 2012 May 10;31(19):2412-22. doi: 10.1038/onc.2011.426. Epub 2011 Sep 26.
77 Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer. 2003 Apr 10;104(3):263-8. doi: 10.1002/ijc.10968.
78 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
79 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
80 Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
81 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
82 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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