Details of the Drug-Related molecule(s) Interaction Atlas

Piperazinyl methyl quinazolinone derivative 2 Drug Info

PMID30185082-Compound-30

Cross-matching ID

PubChem CID

11214940

ChEBI ID

CHEMBL401989

CAS Number

CAS 571203-78-6

TTD Drug ID

DM913KS

General Information of Drug (ID: DM913KS)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MIN-101	DMCJY35	Schizophrenia	6A20	Phase 3	[6]
CT1812	DMBRKZ7	Alzheimer disease	8A20	Phase 2	[7]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[1]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[1]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[1]
Isoindoline derivative 2	DMTE0S3	N. A.	N. A.	Patented	[1]
Isoindoline derivative 1	DMD19QC	N. A.	N. A.	Patented	[1]
Benzamide derivative 9	DMVFSJZ	N. A.	N. A.	Patented	[1]
Benzamide derivative 10	DM9PKU2	N. A.	N. A.	Patented	[1]
PMID30185082-Compound-57	DMNDF1Z	N. A.	N. A.	Patented	[1]
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Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[9]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[13]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Haloperidol	DM96SE0	Delirium		Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[34]
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Drug(s) Affected By Biglycan (BGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[36]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[34]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
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Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[41]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[43]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[38]
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Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[50]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
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Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[58]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[59]
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Drug(s) Affected By Acrosin-binding protein (ACRBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Indomethacin	DMSC4A7	Bursitis		Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
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Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[36]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[37]
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Drug(s) Affected By Fumarate hydratase, mitochondrial (FH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
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Drug(s) Affected By Serine/threonine-protein kinase D2 (PRKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[74]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[75]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sigma intracellular receptor 2 (TMEM97)	TT9NXW4	SGMR2_HUMAN	Ligand	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acrosin-binding protein (ACRBP)	OT0MK3L1	ACRBP_HUMAN	Gene/Protein Processing	[2]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Gene/Protein Processing	[2]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Gene/Protein Processing	[2]
Fumarate hydratase, mitochondrial (FH)	OTEQWU6Q	FUMH_HUMAN	Drug Response	[3]
Lathosterol oxidase (SC5D)	OT41KMW4	SC5D_HUMAN	Gene/Protein Processing	[2]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Gene/Protein Processing	[2]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)	OTRAFFX2	GPX4_HUMAN	Gene/Protein Processing	[4]
Serine/threonine-protein kinase D2 (PRKD2)	OTIFSVI8	KPCD2_HUMAN	Drug Response	[5]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Gene/Protein Processing	[4]

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