Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCA4RM)

Drug Name
GW7604 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9799518
ChEBI ID
CHEMBL195515
TTD Drug ID
DMCA4RM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [3]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [4]
Estrone DM5T6US Acne vulgaris ED80 Approved [4]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [5]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [5]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [5]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [6]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [7]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [8]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [9]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [10]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Fructose DM43AN2 Vomiting MD90 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [14]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [25]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [26]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [27]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Etretinate DM2CZFA Keratosis ED56 Approved [33]
Prednisone DM2HG4X Acute asthma CA23 Approved [34]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [36]
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Drug(s) Affected By Ras-related protein Rab-2A (RAB2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Arsenic DMTL2Y1 N. A. N. A. Approved [45]
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Drug(s) Affected By CCHC-type zinc finger nucleic acid binding protein (CNBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [2]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [49]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [50]
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Drug(s) Affected By Dynein light chain 1, cytoplasmic (DYNLL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Leflunomide DMR8ONJ Arthritis FA20 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [57]
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Drug(s) Affected By GA-binding protein alpha chain (GABPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [59]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [60]
Milchsaure DM462BT Pruritus EC90 Investigative [61]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [62]
2-tert-butylbenzene-1,4-diol DMNXI1E Discovery agent N.A. Investigative [63]
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Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Clozapine DMFC71L Schizophrenia 6A20 Approved [68]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [69]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [70]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Urethane DM7NSI0 N. A. N. A. Phase 4 [73]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [60]
SULFATE DMW0ZBF Discovery agent N.A. Investigative [74]
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Drug(s) Affected By Transcription initiation factor TFIID subunit 9 (TAF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [75]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [75]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [77]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [78]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [60]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [79]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) OTTA5C3U AIMP1_HUMAN Gene/Protein Processing [2]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [2]
CCHC-type zinc finger nucleic acid binding protein (CNBP) OTTGM9NK CNBP_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [2]
Dynein light chain 1, cytoplasmic (DYNLL1) OTR69LHT DYL1_HUMAN Gene/Protein Processing [2]
GA-binding protein alpha chain (GABPA) OT9YB2SA GABPA_HUMAN Gene/Protein Processing [2]
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) OT0EYZAY M3K11_HUMAN Gene/Protein Processing [2]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Gene/Protein Processing [2]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Gene/Protein Processing [2]
Transcription initiation factor TFIID subunit 9 (TAF9) OTCTH3C6 TAF9_HUMAN Gene/Protein Processing [2]

References

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58 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
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60 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
61 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
62 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
63 Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells. Carcinogenesis. 2006 May;27(5):1008-17.
64 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
65 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
66 Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting. Cancer Res. 2004 Apr 1;64(7):2439-48. doi: 10.1158/0008-5472.can-03-2643.
67 Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
68 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
69 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
70 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
71 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
72 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
73 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
74 Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study. Environ Health. 2014 Nov 13;13:94. doi: 10.1186/1476-069X-13-94.
75 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
76 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
77 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
78 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
79 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.