Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCA4RM)

Drug Name
GW7604 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9799518
TTD Drug ID
DMCA4RM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [4]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [5]
Estrone DM5T6US Acne vulgaris ED80 Approved [5]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [6]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [6]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [6]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [7]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [8]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [9]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [10]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [11]
Haloperidol DM96SE0 Delirium Approved [12]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [13]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [15]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Epinephrine DM3KJBC Acute asthma CA23 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
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Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [25]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [27]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [28]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Fructose DM43AN2 Vomiting MD90 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [32]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
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Drug(s) Affected By Integrin beta-1 (ITGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [13]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [40]
Fructose DM43AN2 Vomiting MD90 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
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Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [51]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
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Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [66]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [67]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [68]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [72]
Etretinate DM2CZFA Keratosis ED56 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
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Drug(s) Affected By Ephrin type-A receptor 1 (EPHA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Bortezomib DMNO38U Leukemia Approved [79]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [80]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [81]
Arsenic DMTL2Y1 N. A. N. A. Approved [82]
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Drug(s) Affected By Proteinase-activated receptor 1 (F2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [84]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [86]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Etretinate DM2CZFA Keratosis ED56 Approved [73]
Prednisone DM2HG4X Acute asthma CA23 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
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Drug(s) Affected By Caspase-4 (CASP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [97]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [99]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
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Drug(s) Affected By Dual specificity protein kinase CLK1 (CLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [101]
Leflunomide DMR8ONJ Arthritis FA20 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [80]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [105]
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Drug(s) Affected By Ras-related protein Rab-2A (RAB2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [107]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [110]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [80]
Arsenic DMTL2Y1 N. A. N. A. Approved [82]
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Drug(s) Affected By CCHC-type zinc finger nucleic acid binding protein (CNBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [2]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [112]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [113]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [114]
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Drug(s) Affected By Dynein light chain 1, cytoplasmic (DYNLL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Leflunomide DMR8ONJ Arthritis FA20 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [80]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [117]
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Drug(s) Affected By Paired box protein Pax-5 (PAX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [120]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [121]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [122]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [123]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [124]
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Drug(s) Affected By GA-binding protein alpha chain (GABPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [80]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [127]
Milchsaure DM462BT Pruritus EC90 Investigative [128]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [123]
2-tert-butylbenzene-1,4-diol DMNXI1E Discovery agent N.A. Investigative [129]
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Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [109]
Clozapine DMFC71L Schizophrenia 6A20 Approved [132]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [133]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [134]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [80]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [112]
Urethane DM7NSI0 N. A. N. A. Phase 4 [135]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [127]
SULFATE DMW0ZBF Discovery agent N.A. Investigative [136]
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Drug(s) Affected By Transcription initiation factor TFIID subunit 9 (TAF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [137]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [112]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [137]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [139]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [140]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [127]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [141]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [142]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Gefitinib DM15F0X Colon adenocarcinoma Approved [144]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [146]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [145]
Estrone DM5T6US Acne vulgaris ED80 Approved [150]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) OTTA5C3U AIMP1_HUMAN Gene/Protein Processing [2]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [2]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Gene/Protein Processing [2]
CCHC-type zinc finger nucleic acid binding protein (CNBP) OTTGM9NK CNBP_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [2]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Gene/Protein Processing [2]
Dual specificity protein kinase CLK1 (CLK1) OTG1LACW CLK1_HUMAN Gene/Protein Processing [2]
Dynein light chain 1, cytoplasmic (DYNLL1) OTR69LHT DYL1_HUMAN Gene/Protein Processing [2]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Gene/Protein Processing [2]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [3]

References

1 Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46.
2 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
3 Characterization of molecular and structural determinants of selective estrogen receptor downregulators. Breast Cancer Res Treat. 2007 May;103(1):37-44. doi: 10.1007/s10549-006-9353-2. Epub 2006 Oct 11.
4 Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
5 Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
9 Clinical pipeline report, company report or official report of Shionogi (2011).
10 Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithe... Prostate Cancer Prostatic Dis. 2009;12(4):375-81.
11 Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016 Sep;49(3):165-176. doi: 10.5115/acb.2016.49.3.165. Epub 2016 Sep 29.
12 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
13 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
14 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
15 Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.
16 Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.
17 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
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