Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCHAQ7)

Drug Name
25-hydroxycholesterol Drug Info
Synonyms 25-OHC
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
65094
ChEBI ID
CHEMBL169046
CAS Number
CAS 2140-46-7
TTD Drug ID
DMCHAQ7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Nuclear receptor ROR-gamma (RORG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK2981278 DM25YLM Plaque psoriasis EA90.0 Phase 2 [12]
LYC-55716 DMV8WU9 Non-small-cell lung cancer 2C25.Y Phase 2 [13]
VTP-43742 DMCA8G1 Psoriasis vulgaris EA90 Phase 2 [12]
ESR0114 DMUNM4D Plaque psoriasis EA90.0 Phase 1/2 [14]
AZD0284 DMHBEKM Plaque psoriasis EA90.0 Phase 1 [14]
ARN-6039 DM4D85V Multiple sclerosis 8A40 Phase 1 [15]
TAK-828 DMW43DL Crohn disease DD70 Phase 1 [12]
BBI-6000 DMTG9WM Psoriasis vulgaris EA90 Phase 1 [14]
JNJ-3534 DM49VWQ Psoriasis vulgaris EA90 Phase 1 [14]
JTE-451 DM01JU8 Plaque psoriasis EA90.0 Phase 1 [14]
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Drug(s) Targeting EBV-induced G-protein coupled receptor 2 (GPR183)
Drug Name Drug ID Indication ICD 11 Highest Status REF
27-hydroxycholesterol DM2L6OZ Discovery agent N.A. Investigative [2]
7alpha,25-dihydroxycholesterol DM2N8TW Discovery agent N.A. Investigative [16]
7alpha,27-dihydroxycholesterol DM52UOM Discovery agent N.A. Investigative [2]
7beta-hydroxycholesterol DMPHJZU Discovery agent N.A. Investigative [2]
7beta, 27-dihydroxycholesterol DMSDINR Discovery agent N.A. Investigative [2]
7alpha-hydroxycholesterol DMH6LD0 Discovery agent N.A. Investigative [2]
7beta, 25-dihydroxycholesterol DMYKXWE Discovery agent N.A. Investigative [2]
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Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [17]
Selenium DM25CGV N. A. N. A. Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [22]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [23]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [24]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
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Drug(s) Affected By Acyl-CoA (FADS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [28]
Testosterone DM7HUNW Hot flushes GA30 Approved [29]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [4]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [32]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [34]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Testosterone DM7HUNW Hot flushes GA30 Approved [29]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Clozapine DMFC71L Schizophrenia 6A20 Approved [39]
Menthol DMG2KW7 Back pain ME84.Z Approved [40]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [41]
Arsenic DMTL2Y1 N. A. N. A. Approved [42]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [43]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [44]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [46]
Fluoxetine DM3PD2C Bipolar depression Approved [44]
Fructose DM43AN2 Vomiting MD90 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [44]
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Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Betaine DMGRZW2 Cystitis GC00 Approved [6]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [49]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [50]
Arsenic DMTL2Y1 N. A. N. A. Approved [51]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [52]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [18]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [6]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [53]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [61]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [59]
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Drug(s) Affected By Steroidogenic factor 1 (NR5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Ethanol DMDRQZU Chronic pain MG30 Approved [63]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [64]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [65]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [68]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [69]
27-hydroxycholesterol DM2L6OZ Discovery agent N.A. Investigative [9]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [70]
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Drug(s) Affected By Adiponectin receptor protein 1 (ADIPOR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [71]
Arsenic DMTL2Y1 N. A. N. A. Approved [72]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
Urethane DM7NSI0 N. A. N. A. Phase 4 [75]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [69]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [76]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
EBV-induced G-protein coupled receptor 2 (GPR183) TTME5YJ GP183_HUMAN Agonist [2]
Nuclear receptor ROR-gamma (RORG) TTGV6LY RORG_HUMAN Agonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Gene/Protein Processing [4]
Adiponectin receptor protein 1 (ADIPOR1) OT65ZFZN PAQR1_HUMAN Gene/Protein Processing [5]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Protein Interaction/Cellular Processes [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [7]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Gene/Protein Processing [8]
Steroidogenic factor 1 (NR5A1) OTOULYR4 STF1_HUMAN Gene/Protein Processing [9]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Gene/Protein Processing [10]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Gene/Protein Processing [11]
Vascular cell adhesion protein 1 OTP74K37 VCAM1_HUMAN Gene/Protein Processing [11]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2885).
2 Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.
3 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010 May;24(5):923-9.
4 Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. Eur J Pharmacol. 2007 Oct 1;571(2-3):97-105.
5 Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Biochem Biophys Res Commun. 2005 Sep 2;334(3):924-9. doi: 10.1016/j.bbrc.2005.06.187.
6 Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation. J Biol Chem. 2019 Feb 15;294(7):2436-2448. doi: 10.1074/jbc.RA118.005069. Epub 2018 Dec 13.
7 Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21(2):97-114. doi: 10.1007/s10565-005-0141-2.
8 Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. Oncotarget. 2016 Aug 9;7(32):52392-52403.
9 Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4895-900. doi: 10.1073/pnas.94.10.4895.
10 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
11 LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. Atherosclerosis. 2009 Nov;207(1):38-44.
12 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
13 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
14 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
15 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
16 Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.
17 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
18 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
19 Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochem Pharmacol. 2010 Apr 15;79(8):1200-9. doi: 10.1016/j.bcp.2009.12.007. Epub 2009 Dec 14.
20 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
21 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
22 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
23 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
24 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
25 Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
26 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
27 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
28 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
29 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
30 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
31 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
32 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
33 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
34 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
35 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
36 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
37 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
38 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
39 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
40 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
41 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
42 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
43 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
44 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
45 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
46 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
47 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
48 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
49 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
50 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
51 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
52 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
53 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
54 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
55 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
56 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
57 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
58 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
59 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
60 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
61 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
62 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
63 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
64 Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring. Cell Biol Toxicol. 2023 Oct;39(5):2051-2067. doi: 10.1007/s10565-021-09691-0. Epub 2022 Mar 4.
65 Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis. J Clin Endocrinol Metab. 2007 Aug;92(8):3261-7. doi: 10.1210/jc.2007-0494. Epub 2007 May 22.
66 Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res. 2009 Jul 1;69(13):5415-23.
67 Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. Toxicol Appl Pharmacol. 2014 Jun 15;277(3):231-41.
68 Human steroidogenic factor-1 (hSF-1) regulates progesterone biosynthesis and growth of ovarian surface epithelial cancer cells. J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):14-25. doi: 10.1016/j.jsbmb.2009.11.006. Epub 2010 Jan 4.
69 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
70 Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells. Environ Health Perspect. 2010 Mar;118(3):400-6. doi: 10.1289/ehp.0901161. Epub 2009 Oct 22.
71 Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. Diabetologia. 2005 Aug;48(8):1585-9. doi: 10.1007/s00125-005-1835-y. Epub 2005 Jul 1.
72 Transcriptome responses in blood reveal distinct biological pathways associated with arsenic exposure through drinking water in rural settings of Punjab, Pakistan. Environ Int. 2020 Feb;135:105403. doi: 10.1016/j.envint.2019.105403. Epub 2019 Dec 18.
73 Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors. Horm Cancer. 2018 Jun;9(3):166-174. doi: 10.1007/s12672-018-0331-z. Epub 2018 Mar 30.
74 Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
75 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
76 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.