Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFOZ60)

Drug Name
aconitine Drug Info
Synonyms
aconitine; 302-27-2; CHEBI:2430; Acetylbenzoylaconine; NSC56464; 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoate; 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate; NCGC00163146-01; CAS-302-27-2; DSSTox_RID_81535; DSSTox_CID_26319; SCHEMBL73323; DSSTox_GSID_46319; GTPL2617; DTXSID4046319; CHEMBL1979562; MolPort-002-527-310; Tox21_112015; NSC-56464; AKOS032428256
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
245005
ChEBI ID
CHEMBL2430
CAS Number
CAS 302-27-2
TTD Drug ID
DMFOZ60

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.2 (SCN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
batrachotoxin DMYH9SU Discovery agent N.A. Investigative [8]
veratridine DMUF8JZ Discovery agent N.A. Investigative [2]
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [9]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [10]
Fosphenytoin DMOX3LB Epilepsy 8A60-8A68 Approved [9]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [10]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [11]
Tetrodotoxin DMWMPRG Bacterial infection 1A00-1C4Z Approved [12]
Dyclonine DMU6OFP Pain MG30-MG3Z Approved [13]
Moricizine DMOMBJW Arrhythmia BC9Z Approved [14]
Ethotoin DMXWOCP Complex partial seizure 8A68.0 Approved [15]
Prilocaine DMI7DZ2 Pain MG30-MG3Z Approved [13]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [16]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [19]
Etidronic acid DM1XHYJ Bone Paget disease Approved [16]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [16]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [21]
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Drug(s) Affected By Dynamin-1-like protein (DNM1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [26]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Ethanol DMDRQZU Chronic pain MG30 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
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Drug(s) Affected By Dynamin-like 120 kDa protein, mitochondrial (OPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Ethanol DMDRQZU Chronic pain MG30 Approved [28]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Selenium DM25CGV N. A. N. A. Approved [42]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [43]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Propranolol DM79NTF Angina pectoris BA40 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [52]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [53]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [54]
Mebendazole DMO14SG Ascariasis 1F62 Approved [55]
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Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Capsaicin DMGMF6V Back pain ME84.Z Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [61]
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Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [68]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [69]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [70]
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Drug(s) Affected By Transcription factor HES-1 (HES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
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Drug(s) Affected By Mitofusin-1 (MFN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ethanol DMDRQZU Chronic pain MG30 Approved [28]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [78]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [79]
Bortezomib DMNO38U Leukemia Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [61]
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Drug(s) Affected By Mitochondrial fission factor (MFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [27]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [54]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [61]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [82]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [84]
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Drug(s) Affected By Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [85]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [86]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [82]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [87]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [89]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [90]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [91]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [92]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [93]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [95]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [96]
Cepharanthine DM9Y5JB N. A. N. A. Approved [97]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [98]
Clozapine DMFC71L Schizophrenia 6A20 Approved [99]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [100]
Trifluoperazine DMKBYWI Anxiety Approved [101]
Olanzapine DMPFN6Y Bipolar depression Approved [99]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.2 (SCN2A) TTLJTUF SCN2A_HUMAN Activator [2]
Voltage-gated sodium channel alpha Nav1.5 (SCN5A) TTZOVE0 SCN5A_HUMAN Activator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [4]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Gene/Protein Processing [5]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Post-Translational Modifications [6]
Dynamin-like 120 kDa protein, mitochondrial (OPA1) OTJGNWPW OPA1_HUMAN Gene/Protein Processing [6]
Mitochondrial fission factor (MFF) OTEVIXOM MFF_HUMAN Post-Translational Modifications [6]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Gene/Protein Processing [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Gene/Protein Processing [5]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [7]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) OTPH3RRX HCN4_HUMAN Gene/Protein Processing [5]

References

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43 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
44 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
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46 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
47 Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1alpha. Neuroscience. 2014 Sep 26;277:780-93.
48 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
49 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
50 Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
51 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
52 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
53 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
54 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
55 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
56 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
57 Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study. Arch Toxicol. 2020 Jun;94(6):2225-2237. doi: 10.1007/s00204-020-02746-x. Epub 2020 Apr 23.
58 Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J Med Chem. 2011 Jan 27;54(2):635-54.
59 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
60 Capsaicin, a component of red peppers, stimulates protein kinase CKII activity. BMB Rep. 2010 May;43(5):325-9. doi: 10.5483/bmbrep.2010.43.5.325.
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