Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIBH7M)

Drug Name
L-Tryptophan Drug Info
Synonyms
Ardeytropin; Kalma; LTR; Lyphan; Optimax; Pacitron; Sedanoct; Triptofano; Trofan; Trp; Tryptacin; Tryptan; Tryptophane; Tryptophanum; Triptofano [Spanish]; Tryptophane [French]; Tryptophanum [Latin]; EH 121; MT1; T 0254; Alti-Tryptophan; L-TRYPTOPHAN SIGMA GRADE; L-Trp; L-Tryptofan; L-Tryptophane; L-Ttp; TRP NH3+ COOH; TRP-01; Tryptophan (VAN); Tryptophan [USAN:INN]; H-Trp-oh; Indole-3-alanine; L-Tryptophan (9CI); L-Tryptophan (JP15); Tryptophan (H-3); Tryptophan (USP/INN); L-b-3-Indolylalanine; L-beta-3-Indolylalanine; Tryptophan, L-(8CI); Alanine, 3-indol-3-yl; Alpha'-Amino-3-indolepropionic acid; L-(-)-Tryptophan; L-(-)-Tryptophane; L-a-Aminoindole-3-propionic acid; L-alpha-Aminoindole-3-propionic acid; L-alpha-amino-3-indolepropionic acid; Alpha-Amino-beta-(3-indolyl)-propionic acid; Alpha-amino-beta-(3-indolyl)-pr opionic acid; Propionic acid, 2-amino-3-indol-3-yl; S(-)-1-alpha-Aminoindole-3-propionic acid; (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid; (L)-TRYPTOPHAN; (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid; (S)-(-)-Tryptopha n; (S)-(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid; (S)-2-Amino-3-(3-indolyl)propionic acid; (S)-Tryptophan; (S)-a-Amino-1H-indole-3-propanoic acid; (S)-a-Amino-b-indolepropionic acid; (S)-a-Aminoindole-3-propionic acid; (S)-alpha-Amino-1H-indole-3-propanoic acid; (S)-alpha-Amino-beta-indolepropionic acid; (S)-alpha-Aminoindole-3-propionic acid; (S)-alpha-amino-beta-(3-indolyl)-propionic acid; 1-beta-3-Indolylalanine; 151A3008-4CFE-40C9-AC0B-467EF0CB50EA; 1H-Indole-3-alanine; 1H-Indole-3-alanine (VAN); 1beta-3-Indolylalanine; 2-Amino-3-(lH-indol-3-yl)-propanoic acid; 2-Amino-3-indolylpropanoic acid; 2-amino-3-indol-3-ylpropionic acid; 3-Indol-3-ylalanine
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Therapeutic Class
Antidepressants
Cross-matching ID
PubChem CID
6305
ChEBI ID
CHEBI:16828
CAS Number
CAS 73-22-3
TTD Drug ID
DMIBH7M
VARIDT Drug ID
DR00086
INTEDE Drug ID
DR0991

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [16]
BMS-986205 DM3MAYQ Melanoma 2C30 Phase 3 [17]
INCB24360 DMIJGT9 Urothelial carcinoma 2C92.0 Phase 3 [18]
NLG8189 DM0798Z Melanoma 2C30 Phase 2/3 [17]
DN1406131 DMQFX8R Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
HTI-1090 DMI4TEC Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
KHK2455 DMLSUQ8 Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
LY3381916 DMONZ1L Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
PF-06840003 DMOX6EJ Glioma 2A00.0 Phase 1 [21]
NLG802 DMP9J5V Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Testosterone enanthate DMB6871 N. A. N. A. Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [49]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
⏷ Show the Full List of 21 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Folic Acid DMEMBJC Colorectal carcinoma Approved [25]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Transported By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [32]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [33]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [34]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [35]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [36]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [37]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [38]
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Drug(s) Transported By Proton-coupled amino acid transporter 4 (SLC36A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Proline DMKSTWR Malnutrition 5B50-5B71 Approved [4]
Drug(s) Transported By L-type amino acid transporter 2 (SLC7A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [5]
L-Alanine DMZDN4W Dietary shortage 5B5K Approved [5]
L-Proline DMKSTWR Malnutrition 5B50-5B71 Approved [5]
L-Phenylalanine DMQXI9F Malnutrition 5B50-5B71 Approved [39]
L-Tyrosine DM9O8DT Malnutrition 5B50-5B71 Approved [5]
Drug(s) Metabolized By DOPA decarboxylase (DDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [40]
Droxidopa DM5YF4M Chronic fatigue syndrome 8E49 Approved [41]
Drug(s) Metabolized By Tryptophan 5-hydroxylase 2 (TPH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetrahydrobiopterin DMINZ4W Malnutrition 5B50-5B71 Approved [43]
Sapropterin DM6GE21 Phenylketonuria 5C50.0 Investigative [43]
Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [59]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [60]
Aripiprazole DM3NUMH Bipolar I disorder Approved [61]
Fluoxetine DM3PD2C Bipolar depression Approved [62]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [63]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [64]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [65]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [66]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [67]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Ethacrynic acid DM60QMR Edema MG29 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [71]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [72]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [73]
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Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [78]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [80]
Leflunomide DMR8ONJ Arthritis FA20 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
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Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [83]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [89]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [90]
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Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [95]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [97]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [98]
Estrone DM5T6US Acne vulgaris ED80 Approved [91]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [100]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [101]
Estrone DM5T6US Acne vulgaris ED80 Approved [102]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [103]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [104]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [105]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [106]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Indoleamine 2,3-dioxygenase 1 (IDO1) TTZJYKH I23O1_HUMAN Binder [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Monocarboxylate transporter 10 (SLC16A10) DTPAQJO MOT10_HUMAN Substrate [3]
Proton-coupled amino acid transporter 4 (SLC36A4) DTBS49U S36A4_HUMAN Substrate [4]
L-type amino acid transporter 2 (SLC7A8) DTJF3DX LAT2_HUMAN Substrate [5]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [6]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
DOPA decarboxylase (DDC) DETK9CN DDC_HUMAN Substrate [8]
Tryptophan oxygenase (TRPO) DEGH1QU T23O_HUMAN Substrate [9]
Indoleamine 2,3-dioxygenase 1 (IDO1) DE43MW5 I23O1_HUMAN Substrate [10]
Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DEPTKBQ SYWM_HUMAN Substrate [11]
Tryptophan 5-hydroxylase 1 (TPH1) DEP5BDK TPH1_HUMAN Substrate [12]
Tryptophanyl-tRNA synthetase cytoplasmic (WARS1) DEPVE0M SYWC_HUMAN Substrate [13]
Tryptophan 5-hydroxylase 2 (TPH2) DER6XYF TPH2_HUMAN Substrate [14]
Indoleamine 2,3-dioxygenase 2 (IDO2) DE8BVKA I23O2_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [15]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [15]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [15]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Gene/Protein Processing [15]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Gene/Protein Processing [15]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Gene/Protein Processing [15]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [15]

References

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