Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ03UM)

Drug Name
ROLIPRAM Drug Info
Synonyms
61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Adeo; Rolipram [USAN:INN]; 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone; (R,S)-rolipram; ZK-62711; CHEMBL63; EINECS 262-771-1; BRN 1588548; MLS000069691; CHEBI:104872; HJORMJIFDVBMOB-UHFFFAOYSA-N; 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone; [3H]rolipram
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5092
ChEBI ID
CHEMBL63
CAS Number
CAS 61413-54-5
TTD Drug ID
DMJ03UM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phosphodiesterase 4D (PDE4D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Papaverine DMCA9QP Brain ischaemia 8B1Z Approved [7]
DENBUFYLLINE DM2R15Q Cognitive impairment 6D71 Phase 3 [8]
SOTB07 DMIG4OX Asthma CA23 Phase 3 [9]
AN-2898 DMDK7CL Atopic dermatitis EA80 Phase 2 [10]
GPD-1116 DMOQ7YI Asthma CA23 Phase 2 [11]
TA-7906 DMZTAJL Atopic dermatitis EA80 Phase 2 [12]
HT-0712 DM2WP8F Cognitive impairment 6D71 Phase 2 [9]
TOFIMILAST DMLCUAS Chronic obstructive pulmonary disease CA22 Phase 2 [13]
AWD-12-281 DMVADGZ Rhinitis FA20 Phase 2 [14]
LIRIMILAST DMD4KAU Chronic obstructive pulmonary disease CA22 Phase 2 [13]
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Drug(s) Targeting Phosphodiesterase 5A (PDE5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tadalafil DMJZHT1 Benign prostatic hyperplasia GA90 Approved [15]
Udenafil DM1IQRP Erectile dysfunction HA01.1 Approved [16]
Vardenafil DMTBGW8 Cystic fibrosis CA25 Approved [17]
Dipyridamole DMXY30O Atrial fibrillation BC81.3 Approved [18]
Papaverine DMCA9QP Brain ischaemia 8B1Z Approved [19]
Avanafil DM75CXN Erectile dysfunction HA01.1 Approved [13]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [20]
ICARIIN DMOJQGT N. A. N. A. Phase 3 [21]
EXISULIND DMBY56U Colorectal cancer 2B91.Z Phase 3 [22]
PF-489791 DM3C8GQ Chronic obstructive pulmonary disease CA22 Phase 2 [23]
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Drug(s) Targeting Phosphodiesterase 4B (PDE4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DENBUFYLLINE DM2R15Q Cognitive impairment 6D71 Phase 3 [8]
SOTB07 DMIG4OX Asthma CA23 Phase 3 [24]
BI 1015550 DM6DO2P Idiopathic pulmonary fibrosis CB03.4 Phase 3 [25]
AN-2898 DMDK7CL Atopic dermatitis EA80 Phase 2 [10]
GPD-1116 DMOQ7YI Asthma CA23 Phase 2 [11]
TA-7906 DMZTAJL Atopic dermatitis EA80 Phase 2 [12]
HT-0712 DM2WP8F Cognitive impairment 6D71 Phase 2 [24]
TOFIMILAST DMLCUAS Chronic obstructive pulmonary disease CA22 Phase 2 [26]
AWD-12-281 DMVADGZ Rhinitis FA20 Phase 2 [14]
LIRIMILAST DMD4KAU Chronic obstructive pulmonary disease CA22 Phase 2 [26]
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Drug(s) Targeting Phosphodiesterase 4A (PDE4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dyphylline DM8DZC1 Acute bronchial asthma CA23 Approved [27]
Enprofylline DMFYZKN Asthma CA23 Approved [28]
DENBUFYLLINE DM2R15Q Cognitive impairment 6D71 Phase 3 [8]
SOTB07 DMIG4OX Asthma CA23 Phase 3 [29]
Tofisopam DMTGNWU Hyperuricaemia 5C55.Y Phase 2 [30]
AN-2898 DMDK7CL Atopic dermatitis EA80 Phase 2 [10]
GPD-1116 DMOQ7YI Asthma CA23 Phase 2 [11]
TA-7906 DMZTAJL Atopic dermatitis EA80 Phase 2 [12]
HT-0712 DM2WP8F Cognitive impairment 6D71 Phase 2 [29]
TOFIMILAST DMLCUAS Chronic obstructive pulmonary disease CA22 Phase 2 [31]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [40]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [45]
Prednisone DM2HG4X Acute asthma CA23 Approved [46]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [53]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [58]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
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Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Testosterone enanthate DMB6871 N. A. N. A. Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [66]
Ethanol DMDRQZU Chronic pain MG30 Approved [67]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [68]
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Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [65]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [68]
Arsenic DMTL2Y1 N. A. N. A. Approved [73]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [74]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [32]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [75]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 4A (PDE4A) TTZ97H5 PDE4A_HUMAN Inhibitor [2]
Phosphodiesterase 4B (PDE4B) TTVIAT9 PDE4B_HUMAN Inhibitor [3]
Phosphodiesterase 4D (PDE4D) TTSKMI8 PDE4D_HUMAN Inhibitor [4]
Phosphodiesterase 5A (PDE5A) TTJ0IQB PDE5A_HUMAN Inhibitor [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [6]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Gene/Protein Processing [6]
Mothers against decapentaplegic homolog 1 (SMAD1) OTQSHR25 SMAD1_HUMAN Gene/Protein Processing [6]
Mothers against decapentaplegic homolog 4 (SMAD4) OTWQWCKG SMAD4_HUMAN Gene/Protein Processing [6]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Protein Interaction/Cellular Processes [6]
Vimentin OTGZLW4J VIME_HUMAN Gene/Protein Processing [6]

References

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