Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJS4RP)

Drug Name	PMID26882240-Compound-32 Drug Info
Cross-matching ID	PubChem CID 5288674 ChEBI ID CHEMBL65324 CAS Number CAS 467214-20-6 TTD Drug ID DMJS4RP

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Patented Agent(s)

Approved Drug(s)

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Drug(s) Targeting Hypoxia-inducible factor 1 (HIF-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26882240-Compound-1	DMPAE8N	N. A.	N. A.	Patented	[1]
2,2-dimethylbenzopyran derivative 2	DM9XUYM	N. A.	N. A.	Patented	[1]
Oligooxopiperazine derivative 1	DM74T5L	N. A.	N. A.	Patented	[1]
2,2-dimethylbenzopyran derivative 3	DMTCPSQ	N. A.	N. A.	Patented	[1]
Triptolidenol analog 1	DMZTPUA	N. A.	N. A.	Patented	[1]
Aromatic and heteroaryl compound 1	DMXW0PV	N. A.	N. A.	Patented	[1]
Steroid derivative 4	DMJPYVS	N. A.	N. A.	Patented	[1]
Imidazo [1,2-a]pyridine compound 1	DMWABOJ	N. A.	N. A.	Patented	[1]
PMID26882240-Compound-7	DMOX8E3	N. A.	N. A.	Patented	[1]
PMID26882240-Compound-4	DMS4RLZ	N. A.	N. A.	Patented	[1]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[10]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[13]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[15]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[16]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[20]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[25]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[27]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[32]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[44]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[46]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[63]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[64]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[56]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[67]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[70]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[72]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[73]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[74]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[75]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[77]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[79]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[4]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[87]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[4]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hypoxia-inducible factor 1 (HIF-1)	TTUX68I	NOUNIPROTAC	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[2]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Gene/Protein Processing	[3]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Gene/Protein Processing	[4]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[2]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[2]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[3]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Gene/Protein Processing	[3]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Gene/Protein Processing	[2]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Gene/Protein Processing	[5]

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References

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