Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPB36I)

Drug Name
Tesmilifene Drug Info
Synonyms DPPE; DPPE hydrocloride; Tesmilifene hydrochloride; BMS 217380-01; BMS-217380; BMY-33419; DPPE, BMS; YMB-1002; Anticancer, BMS/Manitoba Univ/MTCR
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
108092
ChEBI ID
CHEBI:93414
CAS Number
CAS 98774-23-3
TTD Drug ID
DMPB36I
INTEDE Drug ID
DR1562

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine receptor (HR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Histamine Phosphate DMV7IM6 Diagnostic imaging N.A. Approved [7]
Repirinast DM6KI0D Asthma CA23 Approved [8]
Levomequitazine DMAYC76 Seasonal allergic rhinitis CA08.01 Phase 3 [9]
ETX-9101 DMZOA2L Asthma CA23 Phase 2 [10]
LCB-2183 DMY4IWC Asthma CA23 Phase 2 [11]
ETS-6218 DMV96BY Fibromyalgia MG30.01 Phase 2 [10]
Votucalis DMW4LTI Allergic rhinitis CA08.0 Phase 2 [12]
OX-NLA DMPEHBJ Allergic rhinitis CA08.0 Discontinued in Phase 3 [13]
CP-118 DMNJD9H Allergic rhinitis CA08.0 Discontinued in Phase 2 [14]
REV-598 DM314CZ Carcinoid syndrome 5B10 Terminated [15]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [23]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [17]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [30]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [31]
Propranolol DM79NTF Angina pectoris BA40 Approved [32]
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Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [38]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
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Drug(s) Affected By Receptor-type tyrosine-protein phosphatase C (PTPRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [48]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [51]
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Drug(s) Affected By Integrin alpha-4 (ITGA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [55]
Folic Acid DMEMBJC Colorectal carcinoma Approved [56]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [5]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [52]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [51]
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Drug(s) Affected By Myeloid cell surface antigen CD33 (CD33)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [60]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [61]
CHLORPYRIFOS DMKPUI6 Discovery agent N.A. Investigative [62]
Drug(s) Affected By Integrin alpha-X (ITGAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [47]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [65]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [5]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [66]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [67]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [68]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [55]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [76]
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Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [81]
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Drug(s) Affected By Prolow-density lipoprotein receptor-related protein 1 (LRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [84]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [5]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [85]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [86]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [87]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine receptor (HR) TT7CXIM NOUNIPROTAC Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Integrin alpha-4 (ITGA4) OTSCAL0V ITA4_HUMAN Gene/Protein Processing [5]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Gene/Protein Processing [6]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Gene/Protein Processing [5]
Myeloid cell surface antigen CD33 (CD33) OTJD4ROQ CD33_HUMAN Gene/Protein Processing [6]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Gene/Protein Processing [5]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Gene/Protein Processing [6]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [6]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Gene/Protein Processing [6]

References

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85 The effect of rosiglitazone on LRP1 expression and amyloid uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment. Int J Neuropsychopharmacol. 2012 Feb;15(1):135-42. doi: 10.1017/S1461145711001611. Epub 2011 Nov 1.
86 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
87 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.