Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQN30Z)

Drug Name
Gamolenic acid Drug Info
Synonyms
gamma-Linolenic acid; GAMOLENIC ACID; 506-26-3; (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid; (Z,Z,Z)-6,9,12-Octadecatrienoic acid; CCRIS 7668; UNII-78YC2MAX4O; Acidum gamolenicum [Latin]; Acido gamolenico [Spanish]; Acide gamolenique [French]; 6,9,12-Octadecatrienoic acid, (Z,Z,Z)-; Gamolenic acid [INN:BAN]; (6,9,12)-linolenic acid; all-cis-6,9,12-Octadecatrienoic acid; cis,cis,cis-6,9,12-Octadecatrienoic acid; 6Z,9Z,12Z-octadecatrienoic acid; 78YC2MAX4O; cis-Delta(6,9,12)-octadecatrienoic acid; CHEMBL464982; CHEBI:28661; Epogam (TN); gamma-linolenic acid
Indication
Disease Entry ICD 11 Status REF
Allergy 4A80-4A85 Approved [1]
Cross-matching ID
PubChem CID
5280933
ChEBI ID
CHEMBL464982
CAS Number
CAS 506-26-3
TTD Drug ID
DMQN30Z
INTEDE Drug ID
DR1995

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [5]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [5]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [5]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [5]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [5]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [5]
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Drug(s) Metabolized By Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [6]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [5]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [2]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [7]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [2]
Omega-6-FA DMBWY8V N. A. N. A. Phase 3 [8]
Arachidonic Acid DMUOQZD Discovery agent N.A. Investigative [9]
alpha-linolenic acid DMY64HE Discovery agent N.A. Investigative [2]
Eicosadienoic acid DMVJK9W N. A. N. A. Investigative [2]
Icosapentum DMF1CM7 N. A. N. A. Investigative [2]
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Drug(s) Affected By PDZ and LIM domain protein 1 (PDLIM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Panobinostat DM58WKG Chronic graft versus host disease Approved [11]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [12]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [12]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [16]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [12]
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Drug(s) Affected By Ferritin heavy chain (FTH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [18]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [24]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [25]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [12]
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Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [26]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [30]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [32]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
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Drug(s) Affected By Clathrin light chain A (CLTA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [35]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [36]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [37]
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Drug(s) Affected By Metallothionein-1G (MT1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Leflunomide DMR8ONJ Arthritis FA20 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [13]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [43]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [44]
Diazepam DM08E9O Alcohol withdrawal Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [13]
Benzbromarone DMC3YUA Gout FA25 Approved [46]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [45]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [45]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [47]
Indomethacin DMSC4A7 Bursitis Approved [46]
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Drug(s) Affected By Stromelysin-3 (MMP11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [51]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [52]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
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Drug(s) Affected By Protein S100-P (S100P)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [59]
Estrone DM5T6US Acne vulgaris ED80 Approved [60]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [61]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
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Drug(s) Affected By Hsc70-interacting protein (ST13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [16]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [53]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [65]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [66]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [67]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [68]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [69]
Diazepam DM08E9O Alcohol withdrawal Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [69]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [72]
Ethacrynic acid DM60QMR Edema MG29 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [69]
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Drug(s) Affected By Trefoil factor 3 (TFF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [74]
Arsenic DMTL2Y1 N. A. N. A. Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [77]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [78]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [78]
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Drug(s) Affected By Acid ceramidase (ASAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [80]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [79]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Fluoxetine DM3PD2C Bipolar depression Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
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Drug(s) Affected By Histone H2A type 1-C (H2AC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [83]
Leflunomide DMR8ONJ Arthritis FA20 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [84]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [85]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [53]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
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Drug(s) Affected By Perilipin-2 (PLIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
Leflunomide DMR8ONJ Arthritis FA20 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Selenium DM25CGV N. A. N. A. Approved [99]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [100]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [101]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
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Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [104]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [32]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [109]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [110]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [112]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [113]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [115]
Gefitinib DM15F0X Colon adenocarcinoma Approved [116]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) DE492CE PGH2_HUMAN Substrate [2]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Gene/Protein Processing [3]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [3]
Aldo-keto reductase family 1 member C4 (AKR1C4) OTW2MMOF AK1C4_HUMAN Gene/Protein Processing [3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Gene/Protein Processing [3]
Clathrin light chain A (CLTA) OTLHOXMQ CLCA_HUMAN Gene/Protein Processing [3]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Gene/Protein Processing [3]
Histone H2A type 1-C (H2AC6) OTF3YK7V H2A1C_HUMAN Gene/Protein Processing [3]
Hsc70-interacting protein (ST13) OTNML6UP F10A1_HUMAN Gene/Protein Processing [3]
Metallothionein-1G (MT1G) OTAV1OCR MT1G_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [4]

References

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11 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
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26 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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31 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
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