Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMREUQ6)

Drug Name
Valsartan Drug Info
Synonyms
valsartan; 137862-53-4; Diovan; Tareg; Provas; L-Valsartan; CGP 48933; Exforge; CGP-48933; (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid; UNII-80M03YXJ7I; N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine; CHEMBL1069; 80M03YXJ7I; CHEBI:9927; C24H29N5O3; (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid; N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; 137863-60-6; AK-58790; Kalpress; Miten; Nisis; Diovan; Vals; Valsarran; Walsartan; Aventis brand of valsartan; CEPA brand of valsartan; Esteve brand of valsartan; Lacer brand of valsartan; Novartis brand of valsartan; Sanol brand of valsartan; Schwarz brand of valsartan; Diovan (TN); Diovan, Valsartan; Valsartan [USAN:INN]; Valtan (TN); Valzaar (TN); Valsartan (JAN/USAN/INN); N-valeryl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)valine; N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine; N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine; L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-(9CI); (S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine; (s)-2-(n-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid; [3H]valsartan
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Nephropathy GC2Z Investigative [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
60846
ChEBI ID
CHEMBL1069
CAS Number
CAS 137862-53-4
TTD Drug ID
DMREUQ6
VARIDT Drug ID
DR00071
INTEDE Drug ID
DR1668
ACDINA Drug ID
D00718

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin II receptor type-1 (AGTR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [4]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [16]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [4]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [17]
Telmisartan DMS3GX2 Hypertension BA00-BA04 Approved [18]
ANGIOTENSIN II DMLWQ27 Increase blood pressure BA04 Approved [19]
SARALASIN DMKS1DV Hypertension BA00-BA04 Approved [20]
Tasosartan DMM13DI Hypertension BA00-BA04 Approved [21]
Eprosartan DM07K2I Hypertension BA00-BA04 Approved [22]
Sparsentan DMMP51W IgA nephropathy MF8Y Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [36]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [38]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [39]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [40]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [41]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [38]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [42]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [43]
Ampicillin DMHWE7P Acute epiglottitis Approved [44]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [5]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [45]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [46]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [47]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [5]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [5]
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Drug(s) Transported By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [49]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [50]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [51]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [8]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [52]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [53]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [54]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [55]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [72]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [51]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [73]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [73]
Cefdinir DMJ7A0H Bacterial infection 1A00-1C4Z Approved [74]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [74]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [75]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [58]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [59]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [36]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [60]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [39]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [41]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [61]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [41]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [65]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [66]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [68]
Estrone DM5T6US Acne vulgaris ED80 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [83]
Prednisone DM2HG4X Acute asthma CA23 Approved [84]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [88]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [79]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [89]
Diazepam DM08E9O Alcohol withdrawal Approved [90]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [91]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [92]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [103]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [104]
Capsaicin DMGMF6V Back pain ME84.Z Approved [105]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [110]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [113]
Ethanol DMDRQZU Chronic pain MG30 Approved [114]
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Drug(s) Affected By Macrophage mannose receptor 1 (MRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [117]
CYCLOPAMINE DMEM2SW Discovery agent N.A. Investigative [118]
Drug(s) Affected By Macrosialin (CD68)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [124]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [124]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [125]
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Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [130]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [131]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [136]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [12]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [137]
Arsenic DMTL2Y1 N. A. N. A. Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [139]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Scavenger receptor cysteine-rich type 1 protein M130 (CD163)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
CHOLINE DM5D9YK Insomnia 7A00-7A0Z Investigative [143]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin II receptor type-1 (AGTR1) TT8DBY3 AGTR1_HUMAN Antagonist [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [5]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [6]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [6]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [10]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Gene/Protein Processing [11]
Coxsackievirus and adenovirus receptor (CXADR) OT9ZP02A CXAR_HUMAN Gene/Protein Processing [12]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Gene/Protein Processing [11]
Macrophage mannose receptor 1 (MRC1) OTTVCOPT MRC1_HUMAN Gene/Protein Processing [11]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Gene/Protein Processing [11]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Gene/Protein Processing [13]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Gene/Protein Processing [14]
Scavenger receptor cysteine-rich type 1 protein M130 (CD163) OT2E32LN C163A_HUMAN Gene/Protein Processing [11]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [15]

References

1 Valsartan FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3937).
3 Valsartan for Prevention of Acute Respiratory Distress Syndrome in Hospitalized Patients With SARS-COV-2 (COVID-19) Infection Disease
4 Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41.
5 High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
6 Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos. 2006 Jul;34(7):1247-54.
7 Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855.
8 Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8.
9 In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists. Eur J Clin Pharmacol. 2000 May;56(2):135-40.
10 Is renoprotection by angiotensin receptor blocker dependent on blood pressure?: the Saitama Medical School, Albuminuria Reduction in Diabetics with Valsartan (STAR) study. Hypertens Res. 2007 Jun;30(6):529-33. doi: 10.1291/hypres.30.529.
11 Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLoS One. 2012;7(6):e39930. doi: 10.1371/journal.pone.0039930. Epub 2012 Jun 29.
12 Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells. J Gen Virol. 2010 Aug;91(Pt 8):1959-1970. doi: 10.1099/vir.0.020065-0. Epub 2010 Apr 14.
13 Effects of valsartan on circulating brain natriuretic peptide and norepinephrine in symptomatic chronic heart failure: the Valsartan Heart Failure Trial (Val-HeFT). Circulation. 2002 Nov 5;106(19):2454-8. doi: 10.1161/01.cir.0000036747.68104.ac.
14 Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023 Jan 1;483:153387. doi: 10.1016/j.tox.2022.153387. Epub 2022 Dec 1.
15 [The relationship between the gene polymorphism of TGF-beta1 and early renal injury in patients with essential hypertension, and the effect of the gene polymorphism of TGF- beta1 on the individual treatment with valsartan]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Aug;24(4):428-31.
16 Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers. J Cardiovasc Pharmacol. 2009 Jul;54(1):47-56.
17 Candesartan: widening indications for this angiotensin II receptor blocker Expert Opin Pharmacother. 2009 Aug;10(12):1995-2007.
18 Deletion of angiotensin II type I receptor reduces hepatic steatosis. J Hepatol. 2009 Jun;50(6):1226-35.
19 The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75.
20 Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.
21 Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54.
22 Clinical profile of eprosartan: a different angiotensin II receptor blocker. Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):253-7.
23 Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43.
24 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
25 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
26 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
27 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
28 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
29 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
30 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
31 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
32 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
33 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
34 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
35 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
36 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
37 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
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