General Information of Drug (ID: DMRQD04)

Drug Name
Tramadol Drug Info
Synonyms Conzip; Ryzolt; Tramadol Hydrochloride; Ultram Er; Rybix Odt; Ultram
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Approved [1]
Pain MG30-MG3Z Approved [2]
Chronic pain MG30 Investigative [1]
Premature ejaculation HA03.0Z Investigative [1]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
33741
ChEBI ID
CHEBI:75725
CAS Number
CAS 123154-38-1
TTD Drug ID
DMRQD04
VARIDT Drug ID
DR00088
INTEDE Drug ID
DR1627
ACDINA Drug ID
D00693

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting 5-HT 2C receptor (HTR2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [9]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [10]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [11]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [12]
Methysergide DM1EF73 Migraine 8A80 Approved [13]
Eltoprazine DMW6C81 Attention deficit hyperactivity disorder 6A05.Z Phase 3 [14]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [15]
SR46349B DM1ODMR Primary insomnia 7A00 Phase 3 [16]
Vabicaserin DM9GZW6 Psychotic disorder 6A20-6A25 Phase 2 [17]
Nuplazid DMOJA5G Alzheimer disease 8A20 Phase 2 [18]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [41]
Metronidazole DMTIVEN Abscess Approved [6]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [42]
Ethanol DMDRQZU Chronic pain MG30 Approved [43]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [44]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [47]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [48]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [49]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [50]
Propranolol DM79NTF Angina pectoris BA40 Approved [51]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [52]
Verapamil DMA7PEW Angina pectoris BA40 Approved [53]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [54]
Estrone DM5T6US Acne vulgaris ED80 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [57]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [58]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [59]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [60]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [61]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [62]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [67]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [68]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [68]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [69]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [71]
Etretinate DM2CZFA Keratosis ED56 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [76]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [79]
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Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [91]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [95]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [97]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [100]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [101]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [102]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [105]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [110]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [111]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [112]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [113]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [6]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [7]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Gene/Protein Processing [7]
kinase isozyme 3, mitochondrial (PDK3) OTCPSTID PDK3_HUMAN Gene/Protein Processing [7]
L-lactate dehydrogenase A chain (LDHA) OTN7K4XB LDHA_HUMAN Gene/Protein Processing [7]
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) OTTIZDFR NDUS1_HUMAN Gene/Protein Processing [7]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Gene/Protein Processing [8]

References

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78 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
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81 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
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