Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS6IJ0)

Drug Name
RHEIN Drug Info
Synonyms
Rhein; 478-43-3; Monorhein; Rheic acid; Rhubarb Yellow; Cassic acid; 4,5-Dihydroxyanthraquinone-2-carboxylic acid; Chrysazin-3-carboxylic acid; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; NSC 38629; Rheinic acid; 1,8-Dihydroxyanthraquinone-3-carboxylic acid; dipropionyl rhein; 1,8-Dihydroxy-3-carboxyanthraquinone; UNII-YM64C2P6UX; Rhein(Monorhein); 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; CCRIS 5129; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; C15H8O6
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10168
ChEBI ID
CHEBI:8825
CAS Number
CAS 478-43-3
TTD Drug ID
DMS6IJ0

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cromoglicate DM74LZK Asthma CA23 Approved [5]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [5]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [6]
BIIB-021 DMPAJ41 Breast cancer 2C60-2C65 Phase 2 [7]
KW-2478 DMJGL72 Solid tumour/cancer 2A00-2F9Z Phase 2 [8]
VER 50589 DMFLZPC Breast cancer 2C60-2C65 Phase 2 [6]
Tanespimycin DMNLQHK Breast cancer 2C60-2C65 Phase 2 [9]
Efungumab DMBHP56 Breast cancer 2C60-2C65 Phase 2 [10]
SNX-5422 DMIU0VP Haematological malignancy 2B33.Y Phase 1/2 [11]
PU3 DMJO0BP Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [12]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [13]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [14]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Ethacrynic acid DM60QMR Edema MG29 Approved [18]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [19]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [20]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [21]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [22]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [22]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [22]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [24]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [25]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [26]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [27]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [28]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [29]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [32]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [33]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Zafirlukast DMHNQOG Asthma CA23 Approved [34]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [32]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [35]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [33]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [32]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [37]
Minoxidil DMA2Z4F Alopecia ED70 Approved [38]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
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Drug(s) Affected By Pro-epidermal growth factor (EGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [51]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [55]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [56]
Fructose DM43AN2 Vomiting MD90 Approved [29]
Ketoprofen DMRKXPT Bursitis Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Selenium DM25CGV N. A. N. A. Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [73]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [76]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [77]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [32]
Quinidine DMLPICK N. A. N. A. Approved [78]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [79]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [80]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [81]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [82]
Gefitinib DM15F0X Colon adenocarcinoma Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [89]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [33]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [90]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [32]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [25]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [32]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [89]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [29]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [91]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [92]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [95]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [97]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [103]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [104]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [105]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [106]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [107]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [108]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [109]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [110]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [111]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [114]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [117]
Meloxicam DM2AR7L Arthritis FA20 Approved [118]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [119]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [120]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [68]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [123]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [127]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [128]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [110]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Verapamil DMA7PEW Angina pectoris BA40 Approved [129]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [115]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Meloxicam DM2AR7L Arthritis FA20 Approved [132]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [133]
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Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [137]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [139]
Folic Acid DMEMBJC Colorectal carcinoma Approved [140]
Menthol DMG2KW7 Back pain ME84.Z Approved [141]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [143]
Gefitinib DM15F0X Colon adenocarcinoma Approved [144]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [146]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [147]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Fluoxetine DM3PD2C Bipolar depression Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [156]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [157]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [158]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [159]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [160]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Gefitinib DM15F0X Colon adenocarcinoma Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [68]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [163]
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Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [171]
Menthol DMG2KW7 Back pain ME84.Z Approved [141]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [172]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Prednisone DM2HG4X Acute asthma CA23 Approved [175]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [175]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [176]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [177]
Epinephrine DM3KJBC Acute asthma CA23 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [179]
Fluoxetine DM3PD2C Bipolar depression Approved [180]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [181]
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Drug(s) Affected By DNA oxidative demethylase ALKBH2 (ALKBH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Testosterone DM7HUNW Hot flushes GA30 Approved [53]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [183]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [184]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [185]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [186]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [187]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 90 alpha (HSP90A) TT78R5H HS90A_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [3]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [3]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [3]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Gene/Protein Processing [4]

References

1 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
2 Apoptotic effects of rhein through the mitochondrial pathways, two death receptor pathways, and reducing autophagy in human liver L02 cells. Environ Toxicol. 2019 Dec;34(12):1292-1302. doi: 10.1002/tox.22830. Epub 2019 Aug 21.
3 The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes. Toxicol Lett. 2016 Nov 16;262:27-38.
4 Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro. J Appl Toxicol. 2021 Sep;41(9):1438-1445. doi: 10.1002/jat.4134. Epub 2021 Jan 12.
5 Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41.
6 Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82.
7 BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther. 2009 Apr;8(4):921-9.
8 Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012 Apr;2(4):e68.
9 Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin Investig Drugs. 2009 Jun;18(6):861-8.
10 Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009 Nov;43(11):1818-23.
11 SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hema... Blood. 2009 Jan 22;113(4):846-55.
12 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
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