Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTCP8K)

Drug Name

propylpyrazoletriol Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5040063
ChEBI ID: CHEBI:64110
CAS Number: CAS 263717-53-9
TTD Drug ID: DMTCP8K

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[12]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[13]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[13]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[13]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[14]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[15]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[16]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[17]
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Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
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Drug(s) Affected By Lysosome-associated membrane glycoprotein 3 (LAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[31]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[32]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
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Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[39]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[38]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[43]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[44]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[45]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[51]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[52]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[53]
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Drug(s) Affected By Apolipoprotein D (APOD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[57]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[58]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[59]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[61]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[68]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[72]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[75]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[79]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[81]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[81]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[87]
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Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[93]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
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Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[96]
Fructose	DM43AN2	Vomiting	MD90	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[100]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[101]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[102]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[9]
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Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[109]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[110]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[111]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[120]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[122]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[122]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
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Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[133]
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Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[134]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[137]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[138]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[120]
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Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[142]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[144]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Mestranol	DMG3F94	Contraception	QA21	Approved	[147]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[148]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Agonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[3]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Gene/Protein Processing	[5]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Gene/Protein Processing	[3]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Gene/Protein Processing	[6]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Gene/Protein Processing	[7]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Post-Translational Modifications	[8]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Gene/Protein Processing	[9]
Lysosome-associated membrane glycoprotein 3 (LAMP3)	OTN0XL3W	LAMP3_HUMAN	Gene/Protein Processing	[10]

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References

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7	Cadmium promotes breast cancer cell proliferation by potentiating the interaction between ERalpha and c-Jun. Mol Endocrinol. 2010 May;24(5):981-92. doi: 10.1210/me.2009-0410. Epub 2010 Mar 10.
8	17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
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10	Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
11	Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
12	Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
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14	17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
15	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
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18	Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
19	Simvastatin modulates the Alzheimer's disease-related gene seladin-1. J Alzheimers Dis. 2012;28(2):297-301.
20	Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
21	Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
22	Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
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24	Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
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26	Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
27	Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
28	Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
29	Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
30	The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
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