Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTRYCI)

Drug Name
tryptanthrin Drug Info
Synonyms GNF-PF-2691; couroupitine a
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
73549
ChEBI ID
CHEBI:9768
CAS Number
CAS 13220-57-0
TTD Drug ID
DMTRYCI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [5]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [6]
BMS-986205 DM3MAYQ Melanoma 2C30 Phase 3 [7]
INCB24360 DMIJGT9 Urothelial carcinoma 2C92.0 Phase 3 [8]
NLG8189 DM0798Z Melanoma 2C30 Phase 2/3 [7]
DN1406131 DMQFX8R Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
HTI-1090 DMI4TEC Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
KHK2455 DMLSUQ8 Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
LY3381916 DMONZ1L Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
PF-06840003 DMOX6EJ Glioma 2A00.0 Phase 1 [11]
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Drug(s) Affected By Calcitonin (CALCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [12]
Fructose DM43AN2 Vomiting MD90 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Folic Acid DMEMBJC Colorectal carcinoma Approved [17]
Nizatidine DMGFV3Z Acid-reflux disorder DA22 Approved [12]
Capsaicin DMGMF6V Back pain ME84.Z Approved [18]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [19]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [20]
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Drug(s) Affected By N-myc proto-oncogene protein (MYCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [28]
Menthol DMG2KW7 Back pain ME84.Z Approved [29]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [30]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [31]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [32]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [33]
Cepharanthine DM9Y5JB N. A. N. A. Approved [34]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [35]
Clozapine DMFC71L Schizophrenia 6A20 Approved [36]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [37]
Trifluoperazine DMKBYWI Anxiety Approved [38]
Olanzapine DMPFN6Y Bipolar depression Approved [36]
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Drug(s) Affected By Microtubule-associated protein tau (MAPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Testosterone enanthate DMB6871 N. A. N. A. Approved [48]
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Drug(s) Affected By Microtubule-associated protein 2 (MAP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [54]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
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Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [3]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [66]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [19]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Arsenic DMTL2Y1 N. A. N. A. Approved [69]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [57]
Etretinate DM2CZFA Keratosis ED56 Approved [74]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [75]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
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Drug(s) Affected By Neuromodulin (GAP43)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Megestrol DMDH9KX Breast cancer 2C60-2C65 Approved [79]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [84]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [91]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [92]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [93]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [105]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [91]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [110]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [92]
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Drug(s) Affected By Somatostatin (SST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
Octreotide DMHIDCJ Acromegaly 5A60.0 Approved [114]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [19]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [116]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
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Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [65]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [119]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [17]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [121]
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Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Gefitinib DM15F0X Colon adenocarcinoma Approved [123]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Panobinostat DM58WKG Chronic graft versus host disease Approved [15]
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Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [131]
Testosterone DM7HUNW Hot flushes GA30 Approved [132]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Indoleamine 2,3-dioxygenase 1 (IDO1) TTZJYKH I23O1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [2]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Gene/Protein Processing [3]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [3]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Post-Translational Modifications [4]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Gene/Protein Processing [3]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Gene/Protein Processing [4]

References

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2 Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells. Biochem Biophys Res Commun. 2007 Jun 22;358(1):79-84. doi: 10.1016/j.bbrc.2007.04.107. Epub 2007 Apr 26.
3 Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells. Chem Biol Interact. 2013 Apr 25;203(2):512-21. doi: 10.1016/j.cbi.2013.03.001. Epub 2013 Mar 13.
4 Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells. J Ethnopharmacol. 2015 Nov 4;174:474-81. doi: 10.1016/j.jep.2015.08.050. Epub 2015 Sep 1.
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