Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU8L7C)

Drug Name
Mepacrine Drug Info
Synonyms
quinacrine; mepacrine; atabrine; Acrinamine; Acriquine; 83-89-6; Quinactine; Antimalarina; Haffkinine; Akrichin; Italchine; acrichine; Erion; Mepacrinum; Quinacrine hydrochloride; Mepacrine [INN:BAN]; St 439; Mepacrinum [INN-Latin]; Mepacrina [INN-Spanish]; atebrin; Malaricida; Methoquine; Palacrin; Italchin; Pentilen; Palusan; Atebrine; Metochin; Mecryl; Quinacrine, Mepacrine; 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine; 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine; HSDB 3253
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
237
ChEBI ID
CHEMBL7568
CAS Number
CAS 83-89-6
TTD Drug ID
DMU8L7C
VARIDT Drug ID
DR01478
INTEDE Drug ID
DR1377

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phospholipase A2 (PLA2G1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [8]
Miltefosine DMND304 Chronic urticaria Approved [9]
Clocortolone DM9ZMQH Exanthem Approved [10]
Clobetasol DMUXP52 Rosacea ED90.0 Approved [11]
Diflorasone DMI9PRJ Exanthem Approved [12]
AllerB DM78DOT Allergy 4A80-4A85 Phase 2b [13]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [14]
MANOALIDE DMB4A8I Arthritis FA20 Phase 2 [15]
MRX-4 DMQZWYE Allergic rhinitis CA08.0 Phase 2 [16]
MRX-6 DMLVQKF Contact dermatitis EK0Z Phase 2 [17]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Folic Acid DMEMBJC Colorectal carcinoma Approved [20]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [37]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [41]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [39]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Gefitinib DM15F0X Colon adenocarcinoma Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [50]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [51]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [59]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [60]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [59]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [61]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [66]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Arsenic DMTL2Y1 N. A. N. A. Approved [72]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [84]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [85]
Paclitaxel DMLB81S Breast carcinoma Approved [86]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [96]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [97]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [99]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [102]
Gefitinib DM15F0X Colon adenocarcinoma Approved [103]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Etretinate DM2CZFA Keratosis ED56 Approved [106]
Prednisone DM2HG4X Acute asthma CA23 Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [108]
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Drug(s) Affected By Casein kinase I isoform alpha (CSNK1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [109]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [110]
Leflunomide DMR8ONJ Arthritis FA20 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [114]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [115]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [116]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
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Drug(s) Affected By Forkhead box protein P3 (FOXP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [123]
GSK618334 DMJPXZ4 Drug abuse 6C4G.1Z Phase 1 [124]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [125]
Dorsomorphin DMKYXJW Discovery agent N.A. Investigative [126]
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Drug(s) Affected By F-box/WD repeat-containing protein 1A (BTRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [130]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [129]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [131]
Calphostin C DM9X2D0 N. A. N. A. Terminated [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [118]
Milchsaure DM462BT Pruritus EC90 Investigative [133]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [134]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [135]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [136]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [137]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [138]
Cepharanthine DM9Y5JB N. A. N. A. Approved [139]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [140]
Clozapine DMFC71L Schizophrenia 6A20 Approved [141]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [142]
Trifluoperazine DMKBYWI Anxiety Approved [143]
Olanzapine DMPFN6Y Bipolar depression Approved [141]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phospholipase A2 (PLA2G1B) TT9V5JH PA21B_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Post-Translational Modifications [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [3]
Casein kinase I isoform alpha (CSNK1A1) OTJ6O1IC KC1A_HUMAN Gene/Protein Processing [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [6]
F-box/WD repeat-containing protein 1A (BTRC) OT2EZDGR FBW1A_HUMAN Gene/Protein Processing [7]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Gene/Protein Processing [7]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [7]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]

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39 Drug Interactions Flockhart Table
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54 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
55 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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