Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUOK4C)

Drug Name

Lisinopril Drug Info

Synonyms

Acerbon; Acercomp; Alapril; Carace; Cipral; Cipril; Coric; Doneka; Hipril (TN); Inhibril; Inopril; LPR; Linopril; Linvas; Lipril; Lisinal; Lisinopril (INN); Lisinopril (anhydrous); Lisinopril anhydrous; Lisinoprilum; Lisinoprilum [Latin]; Lisipril; Lisoril; Lispril; Longes; Loril; Lysinopril; MK 521; MK 522; MK-521; Noperten; Novatec; Presiten; Prinil; Prinivil; Prinivil (TN); Sinopril; Sinopryl; Tensopril; Tensopril (TN); Tensyn; Tersif; Vivatec; Zestril; Zestril (TN)

Indication

Disease Entry	ICD 11	Status	REF
Chronic heart failure	BD1Z	Approved	[1]
Hypertension	BA00-BA04	Approved	[2]
Myocardial infarction	BA41-BA43	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
High blood pressure	BA00	Investigative	[1]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 5362119
ChEBI ID: CHEBI:43755
CAS Number: CAS 76547-98-3
TTD Drug ID: DMUOK4C
VARIDT Drug ID: DR00991
ACDINA Drug ID: D00370

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[14]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[15]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[16]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[17]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[18]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[19]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[20]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[21]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[22]
Enalaprilat	DMFYAM1	Congestive heart failure	BD10	Approved	[23]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[9]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[9]
Quinapril	DMR8H31	Chronic heart failure	BD1Z	Approved	[9]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[31]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[35]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[36]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[37]
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Drug(s) Targeting HUMAN angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[24]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[24]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[25]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[5]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[26]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[27]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[28]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[29]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[5]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[27]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[27]
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Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[38]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[39]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[40]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[43]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[44]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[45]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[46]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[47]
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Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[41]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
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Drug(s) Affected By Natriuretic peptides A (NPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[56]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[57]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[60]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[63]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[64]
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Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[73]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[74]
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Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[82]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[83]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[88]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[89]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[90]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[91]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[94]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[11]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[11]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[11]
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Drug(s) Affected By B2 bradykinin receptor (BDKRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[102]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[4]
HUMAN angiotensin-converting enzyme (ACE)	TTGFNPD	ACE_HUMAN	Inhibitor	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiotensin-converting enzyme (ACE)	OTDF1964	ACE_HUMAN	Gene/Protein Processing	[6]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Gene/Protein Processing	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[8]
B2 bradykinin receptor (BDKRB2)	OTOA9D3W	BKRB2_HUMAN	Drug Response	[9]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Protein Interaction/Cellular Processes	[10]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Gene/Protein Processing	[11]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Gene/Protein Processing	[12]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Gene/Protein Processing	[7]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[13]

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References

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