Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUOK4C)

Drug Name
Lisinopril Drug Info
Synonyms
Acerbon; Acercomp; Alapril; Carace; Cipral; Cipril; Coric; Doneka; Hipril (TN); Inhibril; Inopril; LPR; Linopril; Linvas; Lipril; Lisinal; Lisinopril (INN); Lisinopril (anhydrous); Lisinopril anhydrous; Lisinoprilum; Lisinoprilum [Latin]; Lisipril; Lisoril; Lispril; Longes; Loril; Lysinopril; MK 521; MK 522; MK-521; Noperten; Novatec; Presiten; Prinil; Prinivil; Prinivil (TN); Sinopril; Sinopryl; Tensopril; Tensopril (TN); Tensyn; Tersif; Vivatec; Zestril; Zestril (TN)
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Myocardial infarction BA41-BA43 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
High blood pressure BA00 Investigative [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
5362119
ChEBI ID
CHEMBL43755
CAS Number
CAS 76547-98-3
TTD Drug ID
DMUOK4C
VARIDT Drug ID
DR00991
ACDINA Drug ID
D00370

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [9]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [10]
Captopril DM458UM Chronic heart failure BD1Z Approved [11]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [12]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [13]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [14]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [15]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [16]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [17]
Enalaprilat DMFYAM1 Congestive heart failure BD10 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting HUMAN angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [19]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [19]
Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [20]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [5]
Ampicillin DMHWE7P Acute epiglottitis Approved [21]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [22]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [23]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [24]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [25]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [5]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [22]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [26]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [27]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [28]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [29]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [31]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [32]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [33]
Epinephrine DM3KJBC Acute asthma CA23 Approved [34]
Chlorthalidone DM4DMBT Edema MG29 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [37]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [40]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [44]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [46]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [6]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [49]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [6]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [4]
HUMAN angiotensin-converting enzyme (ACE) TTGFNPD ACE_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Gene/Protein Processing [6]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Gene/Protein Processing [7]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [8]

References

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21 Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
22 High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
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24 Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
25 Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
26 Effects of histamine H2-receptor blockade on the cardiovascular reflex response to lower-body negative pressure in man. Acta Physiol Scand. 1990 May;139(1):161-72. doi: 10.1111/j.1748-1716.1990.tb08909.x.
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31 Effects of an angiotensin converting enzyme inhibitor, ramipril, on intracranial circulation in healthy volunteers. off. Br J Clin Pharmacol. 1992 Sep;34(3):224-30. doi: 10.1111/j.1365-2125.1992.tb04128.x.
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38 Opioid peptides attenuate blood pressure increase in acute respiratory failure. Peptides. 2001 Apr;22(4):631-7. doi: 10.1016/s0196-9781(01)00373-4.
39 Atrial-like Engineered Heart Tissue: An In?Vitro Model of the Human Atrium. Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
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42 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30;128(3):197-202. doi: 10.1016/j.regpep.2004.12.030.
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