Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVWUCF)

Drug Name
Sucrose Drug Info
Synonyms
sucrose; saccharose; 57-50-1; Cane sugar; sugar; Table sugar; White sugar; D-Sucrose; Saccharum; Rohrzucker; Amerfand; Sucrose, pure; Sucrose, dust; D(+)-Saccharose; sacarosa; D(+)-Sucrose; D-(+)-Saccharose; beta-D-Fructofuranosyl alpha-D-glucopyranoside; Microse; Amerfond; Granulated sugar; Rock candy; Beet sugar; Sucraloxum [INN-Latin]; beta-D-Fructofuranosyl-alpha-D-glucopyranoside; Confectioner's sugar; HSDB 500; Sacharose; CCRIS 2120; Sucrose [USAN:JAN]; alpha-D-Glucopyranosyl beta-D-fructofuranoside; CHEBI:17992; D-Saccharose
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5988
ChEBI ID
CHEMBL253582
CAS Number
CAS 57-50-1
TTD Drug ID
DMVWUCF
VARIDT Drug ID
DR00131
INTEDE Drug ID
DR2151

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus Beta-lactamase (Stap-coc blaZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tazobactam DM3XNUI Appendicitis DB10 Approved [12]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [13]
CAZ AVI DMPG4OM Serious infection 1H0Z Phase 3 [14]
Enmetazobactam DMZKTYJ Urinary tract infection GC08 Phase 3 [15]
Vaborbactam DMDCFXJ Urinary tract infection GC08 Phase 3 [16]
MK-7655 DMLMV0O Bacterial infection 1A00-1C4Z Phase 2 [17]
CXL DM3JFZ2 Methicillin-resistant staphylococci infection 1A00-1A09 Phase 2 [18]
RASV-Sp DM4VTX6 Streptococcus infection 1B53 Phase 1 [19]
ME-1071 DMEMQ5J Bacterial infection 1A00-1C4Z Phase 1 [20]
OP-0595 DMECVP9 Bacterial infection 1A00-1C4Z Phase 1 [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Fructokinase (scrK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Maltose DMH0ROP N. A. N. A. Phase 1/2 [6]
Drug(s) Metabolized By Beta-fructofuranosidase (BFRU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Kestose DML93TN N. A. N. A. Preclinical [7]
Drug(s) Metabolized By Glucansucrase (gtf106B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RESORCINOL DMM37C0 Discovery agent N.A. Investigative [22]
CATECHOL DML0YEK Discovery agent N.A. Investigative [23]
ETHYLGALLATE DMJ6PB8 Discovery agent N.A. Investigative [24]
PYROGALLOL DMG5KDY Discovery agent N.A. Investigative [25]
Drug(s) Metabolized By Sucrose-6-phosphate hydrolase scrB (ScrB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Kestose DML93TN N. A. N. A. Preclinical [7]
Drug(s) Metabolized By Sucrose phosphorylase (Spase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Kestose DML93TN N. A. N. A. Preclinical [7]
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Fructose DM43AN2 Vomiting MD90 Approved [11]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [28]
Estrone DM5T6US Acne vulgaris ED80 Approved [29]
Testosterone DM7HUNW Hot flushes GA30 Approved [30]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [29]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [29]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurotensin/neuromedin N (NTS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [38]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [39]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [33]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus Beta-lactamase (Stap-coc blaZ) TTHI19T BLAC_STAAU Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Solute carrier family 45 member 4 (SLC45A4) DTKPHZ6 S45A4_HUMAN Substrate [3]
Solute carrier family 45 member 3 (SLC45A3) DTGEFXH S45A3_HUMAN Substrate [4]
Membrane-associated transporter protein (SLC45A2) DTNCJAT S45A2_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Fructokinase (scrK) DEBW1FU SCRK_FUSMR Substrate [6]
Sucrose phosphorylase (Spase) DEJ4FO2 A0A0M4N1J6_BIFLN Substrate [7]
Glucansucrase (gtf106B) DEWRN24 Q5SBN3_LACRE Substrate [8] , [9]
Beta-fructofuranosidase (BFRU) DECWNTP E1CPU3_BIFLN Substrate [7]
Sucrose-6-phosphate hydrolase scrB (ScrB) DEICTXP B0MAC0_ANACD Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Gene/Protein Processing [10]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Gene/Protein Processing [11]

References

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2 Ten S, Maclaren N: Insulin resistance syndrome in children. J Clin Endocrinol Metab. 2004 Jun;89(6):2526-39.
3 The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):655-60.
4 Putative role of the H(+)/sucrose symporter SLC45A3 as an osmolyte transporter in the kidney. Pflugers Arch. 2016 Aug;468(8):1353-62.
5 Identification of amino acids important for substrate specificity in sucrose transporters using gene shuffling. J Biol Chem. 2012 Aug 31;287(36):30296-304.
6 Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
7 Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.
8 Biosolids application affects the competitive sorption and lability of cadmium, copper, nickel, lead, and zinc in fluvial and calcareous soils. Environ Geochem Health. 2017 Dec;39(6):1365-1379.
9 Growth and tolerance of term infants fed formula with probiotic lactobacillus reuteri. Clin Pediatr (Phila). 2015 Oct;54(12):1175-84.
10 Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. Regul Pept. 2008 Apr 10;147(1-3):96-109. doi: 10.1016/j.regpep.2008.01.009. Epub 2008 Feb 11.
11 Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
12 Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay. N Biotechnol. 2009 Nov 30;26(5):251-9.
13 A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors. Assay Drug Dev Technol. 2009 Apr;7(2):170-9.
14 NXL104 irreversibly inhibits the -lactamase from Mycobacterium tuberculosis. Biochemistry. 2012 Jun 5;51(22):4551-7.
15 Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum--Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20.
16 Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01443-17.
17 Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin . Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5.
18 Beta-Lactam Antibiotics Renaissance. Antibiotics. 2014, 3(2), 193-215.
19 WO patent application no. 2010,0456,20, Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae.
20 Multidrug-resistant Gram-negative bacterial infections: are you ready for the challenge. Curr Clin Pharmacol. 2014 Feb;9(1):27-38.
21 OP0595, a new diazabicyclooctane: mode of action as a serine -lactamase inhibitor, antibiotic and -lactam 'enhancer'. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.
22 Increased infections with beta-blocker use in ischemic stroke, a beta2-receptor mediated process? Neurol Sci. 2017 Jun;38(6):967-974.
23 Catechol glucosides act as donor/acceptor substrates of glucansucrase enzymes of Lactobacillus reuteri. Appl Microbiol Biotechnol. 2017 Jun;101(11):4495-4505.
24 Exploring the effects of plant odors, from tree species of differing host quality, on the response of Lymantria dispar males to female sex pheromones. J Chem Ecol. 2017 Mar;43(3):243-253.
25 Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci. 2017 May;32(4):827-832.
26 Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties. Contraception. 2003 Feb;67(2):93-9. doi: 10.1016/s0010-7824(02)00473-0.
27 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
28 Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001 Jan 9;56(1):31-6. doi: 10.1212/wnl.56.1.31.
29 Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and -fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.
30 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
31 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
32 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
33 Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells. Anticancer Res. 2006 Sep-Oct;26(5A):3205-15.
34 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
35 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
36 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
37 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
38 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
39 A role for neurotensin in bicalutamide resistant prostate cancer cells. Prostate. 2007 Feb 1;67(2):190-202. doi: 10.1002/pros.20518.