Details of the Drug-Related molecule(s) Interaction Atlas

Silymarin Drug Info

Milk thistle extract; Sabal serrulata extract; 84604-20-6; AN-35849; FT-0656490; A835184; (2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxy-phenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chroman-4-one

Cross-matching ID

PubChem CID

5213

ChEBI ID

CHEMBL125451

CAS Number

CAS 65666-07-1

TTD Drug ID

DMXBYQR

VARIDT Drug ID

DR01185

INTEDE Drug ID

DR1913

General Information of Drug (ID: DMXBYQR)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[8]
Diethylcarbamazine	DM1TJ8F	Elephantiasis		Approved	[9]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[10]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[11]
ABT-761	DM3FIC2	Asthma	CA23	Phase 3	[12]
Tenidap	DMHQRYE	Rheumatoid arthritis	FA20	Phase 3	[13]
FPL-62064	DMGF8MZ	Inflammation	1A00-CA43.1	Phase 3	[14]
Flobufen	DMPSG4D	Rheumatoid arthritis	FA20	Phase 3	[15]
Darbufelone	DMYVKM5	Asthma	CA23	Phase 2/3	[16]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[17]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[24]
Metronidazole	DMTIVEN	Abscess		Approved	[25]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[27]
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Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[28]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[29]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[34]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[35]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[36]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[37]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[38]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[3]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[3]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[39]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[38]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[3]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[40]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[41]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[38]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[42]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[45]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[42]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[42]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[47]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[56]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[60]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[61]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[61]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]
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Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[53]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
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Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[86]
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Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[66]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
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Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[102]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[105]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[106]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[108]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[109]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[110]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[114]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[115]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)^{Main DME}	DEYGVN4	UD11_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[3]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[4]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Gene/Protein Processing	[5]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Gene/Protein Processing	[5]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Gene/Protein Processing	[5]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Gene/Protein Processing	[5]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Gene/Protein Processing	[5]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Gene/Protein Processing	[6]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[7]

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