Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXOELT)

Drug Name
Midazolam Drug Info
Synonyms
Dazolam; Dormicum; Midanium; Midazolamum; Midosed; Versed; Midazolam Base; Dormicum (TN); Hypnovel (TN); Midacum (TN); Midazolamum [INN-Latin]; Ro 21-3981; Versed (TN); Midazolam (JAN/INN); Midazolam [INN:BAN:JAN]; 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate; 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride; 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine; 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
Indication
Disease Entry ICD 11 Status REF
Agitation 6A70.3 Approved [1]
Anxiety Approved [1]
Irritability MB24 Approved [2]
Pain MG30-MG3Z Approved [1]
Traumatic brain injury NA07.Z Approved [1]
Epilepsy 8A60-8A68 Phase 3 [3]
Therapeutic Class
Hypnotics and Sedatives
Cross-matching ID
PubChem CID
4192
ChEBI ID
CHEMBL655
CAS Number
CAS 59467-70-8
TTD Drug ID
DMXOELT
VARIDT Drug ID
DR00684
INTEDE Drug ID
DR1086

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Translocator protein (TSPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [14]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [15]
Oxazepam DMXNZM4 Alcohol withdrawal delirium Approved [16]
Temazepam DM02A65 Insomnia 7A00-7A0Z Approved [4]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [17]
Alprazolam DMC7XDN Anxiety Approved [15]
Clotiazepam DM59AZT Anxiety disorder 6B00-6B0Z Approved [18]
Quazepam DMY4D87 Insomnia 7A00-7A0Z Approved [4]
Eszopiclone DM8RZ9H Insomnia 7A00-7A0Z Approved [19]
Triazolam DMETYK5 Insomnia 7A00-7A0Z Approved [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [20]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Folic Acid DMEMBJC Colorectal carcinoma Approved [23]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
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Drug(s) Metabolized By Cytochrome P450 4B1 (CYP4B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Testosterone cypionate DMC1TEV N. A. N. A. Approved [36]
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [42]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [43]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [40]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [40]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [9]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [40]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [40]
Metronidazole DMTIVEN Abscess Approved [48]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [9]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [50]
Estrone DM5T6US Acne vulgaris ED80 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [53]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [54]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [55]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [56]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [57]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [60]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [61]
Cepharanthine DM9Y5JB N. A. N. A. Approved [62]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [63]
Clozapine DMFC71L Schizophrenia 6A20 Approved [64]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [65]
Trifluoperazine DMKBYWI Anxiety Approved [66]
Olanzapine DMPFN6Y Bipolar depression Approved [64]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [70]
Etidronic acid DM1XHYJ Bone Paget disease Approved [67]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [67]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [11]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [73]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [73]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [74]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [11]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [73]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [11]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [76]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [11]
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Drug(s) Affected By Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [79]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [80]
Naltrexone DMUL45H Alcohol dependence 6C40.2 Approved [81]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [82]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Translocator protein (TSPO) TTPTXIN TSPO_HUMAN Modulator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [8]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [9]
Cytochrome P450 4B1 (CYP4B1) DEMF740 CP4B1_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [10]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [11]
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) OTX4UC3O GBRA6_HUMAN Drug Response [12]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [13]

References

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3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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82 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.