Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYA50U)

Drug Name
phloretin Drug Info
Synonyms
phloretin; 60-82-2; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Dihydronaringenin; Phloretol; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; UNII-S5J5OE47MK; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; CCRIS 7459; beta-(p-Hydroxyphenyl)phloropropiophenone; 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone; EINECS 200-488-7; NSC407292; S5J5OE47MK; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4788
ChEBI ID
CHEBI:17276
CAS Number
CAS 60-82-2
TTD Drug ID
DMYA50U
VARIDT Drug ID
DR00911
INTEDE Drug ID
DR1943

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 23 member 1 (SLC23A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [15]
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [22]
Metronidazole DMTIVEN Abscess Approved [23]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [24]
Ethanol DMDRQZU Chronic pain MG30 Approved [25]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [27]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [30]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [29]
Haloperidol DM96SE0 Delirium Approved [29]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A8 (UGT1A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [32]
Empagliflozin DMRF9YK Type-1 diabetes 5A10 Approved [33]
Darolutamide DMV7YFT Prostate cancer 2C82.0 Approved [34]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [35]
EUGENOL DM7US1H Discovery agent N.A. Patented [5]
Chrysin DM7V2LG Discovery agent N.A. Investigative [5]
Anthraflavic acid DMN1YFU N. A. N. A. Investigative [5]
Cis-4-hydroxytamoxifen DMRFTB5 N. A. N. A. Investigative [35]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A7 (UGT1A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [32]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
EUGENOL DM7US1H Discovery agent N.A. Patented [5]
Chrysin DM7V2LG Discovery agent N.A. Investigative [5]
Anthraflavic acid DMN1YFU N. A. N. A. Investigative [5]
Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Fructose DM43AN2 Vomiting MD90 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Fructose DM43AN2 Vomiting MD90 Approved [55]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [56]
Estrone DM5T6US Acne vulgaris ED80 Approved [9]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [9]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [9]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [9]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [59]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
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Drug(s) Affected By Sodium/hydrogen exchanger 1 (SLC9A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Paclitaxel DMLB81S Breast carcinoma Approved [71]
Arsenic DMTL2Y1 N. A. N. A. Approved [72]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Gefitinib DM15F0X Colon adenocarcinoma Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [81]
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Drug(s) Affected By Sodium/hydrogen exchanger 9B2 (SLC9B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [84]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [87]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [11]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [82]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Estrone DM5T6US Acne vulgaris ED80 Approved [92]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [93]
Testosterone DM7HUNW Hot flushes GA30 Approved [94]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Mestranol DMG3F94 Contraception QA21 Approved [6]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [97]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aquaporin-9 (AQP9) TTQEI32 AQP9_HUMAN Inhibitor [2]
Chloride channel protein 3 (CLC-3) TT8XNZ7 CLCN3_HUMAN Blocker (channel blocker) [3]
Solute carrier family 23 member 1 (SLC23A1) TT6XAGK S23A1_HUMAN Inhibitor [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DE2GB8N UD18_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DEZO4N3 UD17_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Protein Interaction/Cellular Processes [6]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Gene/Protein Processing [7]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Gene/Protein Processing [8]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Protein Interaction/Cellular Processes [9]
Sodium/hydrogen exchanger 1 (SLC9A1) OT6HNHFV SL9A1_HUMAN Gene/Protein Processing [10]
Sodium/hydrogen exchanger 9B2 (SLC9B2) OTZVOY8T SL9B2_HUMAN Gene/Protein Processing [11]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Gene/Protein Processing [12]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Gene/Protein Processing [13]
UDP-glucuronosyltransferase 1-6 OTGTQ2C9 UD16_HUMAN Gene/Protein Processing [14]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Gene/Protein Processing [14]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4285).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 696).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 702).
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21 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
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25 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
26 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
27 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
28 Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4.
29 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
30 The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
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32 Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85.
33 Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8.
34 Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759.
35 Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14.
36 Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. doi: 10.1002/jat.3809. Epub 2019 May 7.
37 Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
38 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
39 Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol. 2009 Mar;28(3):119-29.
40 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
41 Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. doi: 10.1164/rccm.200501-041OC. Epub 2005 Jul 7.
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44 Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep;19(9):1712-20.
45 Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Circulation. 2005 Aug 2;112(5):727-36. doi: 10.1161/CIRCULATIONAHA.104.500959. Epub 2005 Jul 25.
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47 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
48 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
49 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
50 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
51 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
52 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
53 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
54 Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties. Contraception. 2003 Feb;67(2):93-9. doi: 10.1016/s0010-7824(02)00473-0.
55 Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
56 Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001 Jan 9;56(1):31-6. doi: 10.1212/wnl.56.1.31.
57 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
58 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
59 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
60 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
61 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
62 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
63 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
64 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
65 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
66 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
67 Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines. Clin Cancer Res. 2004 Oct 15;10(20):7022-30. doi: 10.1158/1078-0432.CCR-04-0879.
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