Details of Disease

General Information of Disease (ID: DIS2FDOT)

• Disease Name: Obstructive jaundice
• Synonyms: obstructive hyperbilirubinemia; cholestatic jaundice syndrome; cholestatic jaundice
• Definition: A finding indicating increased bilirubin levels in the blood and urine, due to intrahepatic or extrahepatic obstruction of the biliary system.
• Disease Hierarchy:
  DISUV4DU: Non-neoplastic bile duct disorder
  DISDJJWE: Cholestasis
  DIS2FDOT: Obstructive jaundice
• Disease Identifiers:
  MONDO ID: MONDO_0006874
  MESH ID: D041781
  UMLS CUI: C0022354
  MedGen ID: 43988
  SNOMED CT ID: 44018007

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Menadiol sodium diphosphate	DMP9N85	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BRD1	TTT09OB	Limited	Biomarker	[2]
DAO	TT7Y3EJ	moderate	Altered Expression	[3]
SLC10A1	TTWZRY5	moderate	Altered Expression	[4]
ABCB4	TTJUXV6	Strong	Biomarker	[5]
ADM	TTV14YH	Strong	Biomarker	[6]
CD14	TT6I7DC	Strong	Biomarker	[7]
CFH	TTUW6OP	Strong	Biomarker	[6]
LBP	TTVQJLY	Strong	Biomarker	[7]
PCNA	TTLG1PD	Strong	Therapeutic	[8]
PNPLA6	TTWAQU2	Strong	Genetic Variation	[9]
UCP2	TTSC2YM	Strong	Biomarker	[10]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A13	DTDSYAQ	moderate	Genetic Variation	[11]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GPT	DER5HFI	Limited	Biomarker	[12]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
OPN1MW	OTPJ7LX4	Limited	Biomarker	[13]
PPP1R15A	OTYG179K	Limited	Altered Expression	[2]
AIP	OTDJ3OSV	moderate	Biomarker	[14]
NPHP3	OT8U8ELA	moderate	Genetic Variation	[15]
GGTLC1	OTWJKUHQ	Strong	Biomarker	[16]

References

• [1] Menadiol sodium diphosphate FDA Label
• [2] Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway.World J Gastroenterol. 2019 Nov 7;25(41):6205-6221. doi: 10.3748/wjg.v25.i41.6205.
• [3] Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-B pathways.PLoS One. 2019 Oct 31;14(10):e0223651. doi: 10.1371/journal.pone.0223651. eCollection 2019.
• [4] Sodium Taurocholate Cotransporting Polypeptide (NTCP) Deficiency Hidden Behind Citrin Deficiency in Early Infancy: A Report of Three Cases.Front Genet. 2019 Nov 7;10:1108. doi: 10.3389/fgene.2019.01108. eCollection 2019.
• [5] Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.PLoS One. 2011;6(10):e25942. doi: 10.1371/journal.pone.0025942. Epub 2011 Oct 14.
• [6] Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats.Peptides. 2010 May;31(5):872-7. doi: 10.1016/j.peptides.2010.01.010. Epub 2010 Feb 2.
• [7] The kinetic expression of lipopolysaccharide-binding protein and CD14 gene in obstructive jaundice.J Invest Surg. 2015 Feb;28(1):18-23. doi: 10.3109/08941939.2014.943858. Epub 2014 Aug 5.
• [8] Obstructive jaundice alters proliferating cell nuclear antigen expression in rat small intestine.World J Surg. 2003 Oct;27(10):1161-4. doi: 10.1007/s00268-003-6992-x. Epub 2003 Aug 18.
• [9] The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview.J Inherit Metab Dis. 2015 Jan;38(1):19-40. doi: 10.1007/s10545-014-9776-6. Epub 2014 Nov 21.
• [10] Bile duct obstruction is associated with early postoperative upregulation of liver uncoupling protein-2 and reduced circulating glucose concentration in the rat.Nutrition. 2010 Apr;26(4):405-10. doi: 10.1016/j.nut.2009.05.005. Epub 2009 Jul 24.
• [11] Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13 mutations among Thai infants.BMC Gastroenterol. 2012 Oct 15;12:141. doi: 10.1186/1471-230X-12-141.
• [12] A Simple and Easily Reproducible Model of Reversible Obstructive Jaundice in Rats.In Vivo. 2019 May-Jun;33(3):699-706. doi: 10.21873/invivo.11528.
• [13] Endoscopic papillary large balloon dilatation for the extraction of common bile duct stones.Rev Esp Enferm Dig. 2019 May;111(5):358-363. doi: 10.17235/reed.2019.5865/2018.
• [14] Autoimmune Pancreatitis.Am J Gastroenterol. 2018 Sep;113(9):1301. doi: 10.1038/s41395-018-0146-0. Epub 2018 Jun 18.
• [15] Isosorbide dinitrate in nephronophthisis treatment.Am J Med Genet A. 2018 Apr;176(4):1023-1026. doi: 10.1002/ajmg.a.38650.
• [16] Not only Alagille syndrome. Syndromic paucity of interlobular bile ducts secondary to HNF1 deficiency: a case report and literature review.Ital J Pediatr. 2019 Feb 21;45(1):27. doi: 10.1186/s13052-019-0617-y.