General Information of Disease (ID: DISSJR1P)

Disease Name Androgenetic alopecia
Synonyms androgenic alopecia; male pattern baldness; alopecia androgenetica, male pattern baldness; androgenetic alopecia
Disease Hierarchy
DIS9CG29: Endocrine alopecia
DIS37HU4: Alopecia
DISSJR1P: Androgenetic alopecia
Disease Identifiers
MONDO ID
MONDO_0005339
MESH ID
D000505
UMLS CUI
C0162311
MedGen ID
56404
SNOMED CT ID
201144006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 21 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCC2 TTFLHJV Limited Biomarker [1]
AGXT TTF5NVW Limited Biomarker [2]
DKK2 TTST5KX Limited Genetic Variation [3]
FAF1 TTSKL3G Limited Genetic Variation [4]
HDAC9 TT8M4E1 Limited Genetic Variation [4]
MAPT TTS87KH Limited Genetic Variation [4]
MTHFR TTQWOU1 Limited Biomarker [1]
OPHN1 TTU7HRD Limited Genetic Variation [4]
PRKAR1A TTNAHEX Limited Biomarker [5]
RUNX1 TTWIN3H Limited Genetic Variation [4]
SRD5A2 TTT02K8 moderate Genetic Variation [3]
VDR TTK59TV moderate Biomarker [6]
BRD4 TTSRAOU Strong Biomarker [7]
CRH TTA7YIZ Strong Biomarker [8]
KLK3 TTS78AZ Strong Biomarker [9]
NCOA4 TT8OY02 Strong Biomarker [10]
OTC TT5KIO9 Strong Biomarker [11]
PARP1 TTVDSZ0 Strong Biomarker [12]
RHOA TTP2U16 Strong Biomarker [13]
SRD5A1 TTTU72V Strong Genetic Variation [14]
TNFRSF10A TT5WLRX Strong Biomarker [15]
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⏷ Show the Full List of 21 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC14A2 DT8QC7K Limited Genetic Variation [4]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
AKR1C4 DEAJN47 Limited Biomarker [16]
DHRS9 DEGTU5I Limited Biomarker [16]
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This Disease Is Related to 26 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ARL17B OTXZD3DG Limited Genetic Variation [4]
DPY30 OTLHCJ6C Limited Genetic Variation [4]
EBF1 OTZ61YYH Limited Genetic Variation [4]
EDAR OT3W2UQS Limited Genetic Variation [3]
EIF3E OTI0WG98 Limited Genetic Variation [4]
EMC2 OT3S2TWF Limited Genetic Variation [4]
FAM53B OTVD7OU6 Limited Genetic Variation [4]
FGF5 OTQXGHBY Limited Genetic Variation [4]
GORAB OTP65YD7 Limited Genetic Variation [4]
IRF4 OT1DHQ1P Limited Genetic Variation [4]
KANSL1 OTYNSNNZ Limited Genetic Variation [3]
KLF15 OTGMQMVR Limited Genetic Variation [4]
LRMDA OTIPNKTU Limited Genetic Variation [4]
MKLN1 OTHMIMH6 Limited Genetic Variation [4]
MRPS22 OTIVNAJL Limited Genetic Variation [4]
RSPO2 OT3HHXU0 Limited Genetic Variation [4]
SPPL2C OTUTY2ED Limited Genetic Variation [17]
SSPN OTYG2SL7 Limited Genetic Variation [4]
TBX15 OTAZ9QDX Limited Genetic Variation [4]
TGFB1I1 OTIK337D Limited Biomarker [18]
THADA OTYZQX0F Limited Genetic Variation [3]
CARD14 OTADQHOV moderate Biomarker [19]
HR OTHEZWPW moderate Biomarker [20]
AGA OTNWT1WB Strong Biomarker [21]
COL17A1 OTID5AH2 Strong Biomarker [22]
SUPV3L1 OT416O2G Strong Biomarker [23]
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⏷ Show the Full List of 26 DOT(s)

References

1 Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9.
2 Blastic transformation after splenectomy in a patient with nonvillous splenic marginal zone lymphoma with p53 overexpression: a case report.Int J Hematol. 2005 Jun;81(5):417-20. doi: 10.1532/ijh97.05017.
3 Detection and interpretation of shared genetic influences on 42 human traits.Nat Genet. 2016 Jul;48(7):709-17. doi: 10.1038/ng.3570. Epub 2016 May 16.
4 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.Nat Commun. 2017 Nov 17;8(1):1584. doi: 10.1038/s41467-017-01490-8.
5 PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.JCI Insight. 2018 Jan 25;3(2):e98394. doi: 10.1172/jci.insight.98394. eCollection 2018 Jan 25.
6 Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer.Biol Pharm Bull. 2012;35(4):582-7. doi: 10.1248/bpb.35.582.
7 Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.Cell Rep. 2014 Sep 25;8(6):1919-1929. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.
8 CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.PLoS One. 2011 Feb 16;6(2):e16377. doi: 10.1371/journal.pone.0016377.
9 Serum androgens and prostate-specific antigen levels in androgenetic alopecia: is there a difference between frontal and vertex baldness?.J Eur Acad Dermatol Venereol. 2018 Oct;32(10):1815-1818. doi: 10.1111/jdv.14758. Epub 2018 Jan 12.
10 Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia.J Cutan Pathol. 2005 Sep;32(8):567-71. doi: 10.1111/j.0303-6987.2005.00397.x.
11 Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients.Dermatol Ther. 2018 Nov;31(6):e12741. doi: 10.1111/dth.12741. Epub 2018 Oct 8.
12 Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.Mech Ageing Dev. 2010 Jun;131(6):389-404. doi: 10.1016/j.mad.2010.05.005. Epub 2010 Jun 8.
13 Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome.Nat Genet. 2019 Oct;51(10):1438-1441. doi: 10.1038/s41588-019-0498-4. Epub 2019 Sep 30.
14 Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia.J Dermatol Sci. 2003 Apr;31(2):135-41. doi: 10.1016/s0923-1811(02)00145-7.
15 Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study.J Clin Oncol. 2009 Sep 10;27(26):4413-21. doi: 10.1200/JCO.2008.21.7422. Epub 2009 Aug 3.
16 Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone.Biochem Biophys Res Commun. 2016 Mar 25;472(1):250-4. doi: 10.1016/j.bbrc.2016.02.099. Epub 2016 Feb 26.
17 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.PLoS Genet. 2012 May;8(5):e1002746. doi: 10.1371/journal.pgen.1002746. Epub 2012 May 31.
18 Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla.J Dermatol Sci. 2011 Jan;61(1):1-6. doi: 10.1016/j.jdermsci.2010.10.015. Epub 2010 Nov 3.
19 Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia.J Vis Exp. 2018 Jan 27;(131):56406. doi: 10.3791/56406.
20 A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.Genomics. 2006 Apr;87(4):520-6. doi: 10.1016/j.ygeno.2005.12.005. Epub 2006 Feb 7.
21 Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene.Exp Dermatol. 2010 Nov;19(11):1026-8. doi: 10.1111/j.1600-0625.2010.01132.x. Epub 2010 Sep 7.
22 Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation.Tissue Cell. 2019 Aug;59:33-38. doi: 10.1016/j.tice.2019.06.001. Epub 2019 Jun 21.
23 Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.Mamm Genome. 2009 Feb;20(2):92-108. doi: 10.1007/s00335-008-9168-z. Epub 2009 Jan 15.