Details of Disease

General Information of Disease (ID: DISX5NCF)

• Disease Name: Sinusitis
• Disease Class: CA0A: Chronic rhinosinusitis
• Definition: An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity.
• Disease Hierarchy:
  DIS184KT: Skin inflammation
  DISWD40R: Disease
  DIS7WBKM: Paranasal sinus disorder
  DISX5NCF: Sinusitis
• ICD Code:
  ICD-11: ICD-11: CA0A.Z
  ICD-10: ICD-10: J01, J32
• Disease Identifiers:
  MONDO ID: MONDO_0005961
  MESH ID: D012852
  UMLS CUI: C0037199
  MedGen ID: 20772
  HPO ID: HP:0000246
  SNOMED CT ID: 36971009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 18 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amoxicillin	DMUYNEI	Approved	Small molecular drug	[1]
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[2]
Ampicillin	DMHWE7P	Approved	Small molecular drug	[3]
Bacampicillin	DMP54C7	Approved	Small molecular drug	[4]
Cefuroxime	DMSIMD8	Approved	Small molecular drug	[5]
Clavulanate	DM2FGRT	Approved	Small molecular drug	[6]
Cloxacillin	DMUTL7O	Approved	Small molecular drug	[7]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[8]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[9]
Ephedrine	DMMV0KW	Approved	Small molecular drug	[10]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[11]
Meticillin	DMIKHN0	Approved	Small molecular drug	[12]
Minocycline	DMVN5OH	Approved	Small molecular drug	[13]
Mometasone	DM45OJN	Approved	Small molecular drug	[14]
Oxacillin	DMTAFY4	Approved	Small molecular drug	[15]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[16]
Pseudoephedrine	DMIVJ0D	Approved	Small molecular drug	[10]
Tetracycline	DMZA017	Approved	Small molecular drug	[17]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ZP-011	DMCS2SJ	Investigative	NA	[18]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AZGP1	TTUPYLV	Limited	Biomarker	[19]
MET	TTNDSF4	Limited	Biomarker	[19]
CFTR	TTRLZHP	Strong	Biomarker	[20]
IL13	TT0GVCH	Strong	Biomarker	[21]
EPX	TTCIO0M	Definitive	Genetic Variation	[22]
LTC4S	TTW7OTG	Definitive	Genetic Variation	[23]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SMOX	DEOH5V3	Definitive	Biomarker	[24]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PIP	OTH719AH	Limited	Biomarker	[19]
PPP1R9B	OTDCTHTT	Limited	Biomarker	[19]
RSPH4A	OTNDPGEE	Disputed	Biomarker	[25]
CLEC4D	OTT7X1UC	Strong	Altered Expression	[26]
AP5B1	OTZGM9QA	Definitive	Genetic Variation	[22]

References

• [1] Amoxicillin FDA Label
• [2] Amphotericin B FDA Label
• [3] Ampicillin FDA Label
• [4] Bacampicillin FDA Label
• [5] Cefuroxime FDA Label
• [6] Clavulanate FDA Label
• [7] Cloxacillin FDA Label
• [8] Demeclocycline FDA Label
• [9] Doxycycline FDA Label
• [10] Ephedrine FDA Label
• [11] Facial cellulitis associated with Pseudomonas aeruginosa complicating ophthalmic herpes zoster. Dermatol Online J. 2004 Oct 15;10(2):20.
• [12] Diagnosis, management and treatment of orbital and periorbital cellulitis in children. Emerg Nurse. 2016 Apr;24(1):30-5; quiz 37.
• [13] Minocycline FDA Label
• [14] Mometasone FDA Label
• [15] Oxacillin FDA Label
• [16] Oxytetracycline FDA Label
• [17] Tetracycline FDA Label
• [18] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [19] Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma.Laryngoscope. 2008 May;118(5):881-9. doi: 10.1097/MLG.0b013e31816b4b6f.
• [20] Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.Int Forum Allergy Rhinol. 2015 Feb;5(2):178-81. doi: 10.1002/alr.21440. Epub 2014 Oct 31.
• [21] IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma.Allergy Asthma Immunol Res. 2010 Apr;2(2):134-40. doi: 10.4168/aair.2010.2.2.134. Epub 2010 Mar 24.
• [22] Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization.Epigenetics. 2019 May;14(5):445-466. doi: 10.1080/15592294.2019.1590085. Epub 2019 Mar 28.
• [23] Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis.Am J Rhinol. 2006 Sep-Oct;20(5):545-9. doi: 10.2500/ajr.2006.20.2934.
• [24] Preclinical therapeutic efficacy of the ciprofloxacin-eluting sinus stent for Pseudomonas aeruginosa sinusitis.Int Forum Allergy Rhinol. 2018 Apr;8(4):482-489. doi: 10.1002/alr.22081. Epub 2018 Jan 15.
• [25] RSPH3 Mutations Cause Primary Ciliary Dyskinesia with Central-Complex Defects and a Near Absence of Radial Spokes. Am J Hum Genet. 2015 Jul 2;97(1):153-62. doi: 10.1016/j.ajhg.2015.05.004. Epub 2015 Jun 11.
• [26] C-type lectin receptors mRNA expression in patients with otitis media with effusion.Int J Pediatr Otorhinolaryngol. 2013 Nov;77(11):1846-51. doi: 10.1016/j.ijporl.2013.08.025. Epub 2013 Sep 17.