Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT0T71OW)

DOT Name Rab11 family-interacting protein 1 (RAB11FIP1)
Synonyms Rab11-FIP1; Rab-coupling protein
Gene Name RAB11FIP1
Related Disease
Breast cancer ( )
Breast carcinoma ( )
Advanced cancer ( )
Neoplasm ( )
Stroke ( )
UniProt ID
RFIP1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
4D0G
Pfam ID
PF00168 ; PF09457
Sequence
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS
LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR
RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT
SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS
FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT
KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA
EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSS
PIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPVPNSGSSALGSLFKQPS
FPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGAS
VPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNP
AWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLP
SIPEVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADR
LVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVE
NFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATII
SENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLV
RVMEETPNILRIPTQVGKKAGKM
Function A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
Tissue Specificity Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
KEGG Pathway
Endocytosis (hsa04144 )

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Breast cancer DIS7DPX1 Strong Altered Expression [1]
Breast carcinoma DIS2UE88 Strong Altered Expression [1]
Advanced cancer DISAT1Z9 Limited Biomarker [2]
Neoplasm DISZKGEW Limited Biomarker [3]
Stroke DISX6UHX Limited Biomarker [4]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Vinblastine DM5TVS3 Approved Rab11 family-interacting protein 1 (RAB11FIP1) affects the response to substance of Vinblastine. [25]
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23 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [5]
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [6]
Tretinoin DM49DUI Approved Tretinoin increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [7]
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [8]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [9]
Cisplatin DMRHGI9 Approved Cisplatin affects the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [10]
Estradiol DMUNTE3 Approved Estradiol decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [11]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [12]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide affects the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [14]
Calcitriol DM8ZVJ7 Approved Calcitriol increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [15]
Vorinostat DMWMPD4 Approved Vorinostat increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [16]
Testosterone DM7HUNW Approved Testosterone increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [15]
Decitabine DMQL8XJ Approved Decitabine affects the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [10]
Marinol DM70IK5 Approved Marinol decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [17]
Menadione DMSJDTY Approved Menadione affects the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [14]
Panobinostat DM58WKG Approved Panobinostat increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [16]
Demecolcine DMCZQGK Approved Demecolcine increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [18]
Urethane DM7NSI0 Phase 4 Urethane increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [19]
SNDX-275 DMH7W9X Phase 3 SNDX-275 increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [20]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [22]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [23]
Coumestrol DM40TBU Investigative Coumestrol decreases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [24]
Butanoic acid DMTAJP7 Investigative Butanoic acid increases the expression of Rab11 family-interacting protein 1 (RAB11FIP1). [16]
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⏷ Show the Full List of 23 Drug(s)
4 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Quercetin DM3NC4M Approved Quercetin decreases the phosphorylation of Rab11 family-interacting protein 1 (RAB11FIP1). [13]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Rab11 family-interacting protein 1 (RAB11FIP1). [21]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 affects the phosphorylation of Rab11 family-interacting protein 1 (RAB11FIP1). [13]
Coumarin DM0N8ZM Investigative Coumarin decreases the phosphorylation of Rab11 family-interacting protein 1 (RAB11FIP1). [13]
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References

1 Downregulation of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in breast cancer.J Cancer. 2017 Jan 1;8(1):1-8. doi: 10.7150/jca.16602. eCollection 2017.
2 Rab25 and RCP in cancer progression.Arch Pharm Res. 2019 Feb;42(2):101-112. doi: 10.1007/s12272-019-01129-w. Epub 2019 Feb 14.
3 RCP induces Slug expression and cancer cell invasion by stabilizing 1 integrin.Oncogene. 2017 Feb 23;36(8):1102-1111. doi: 10.1038/onc.2016.277. Epub 2016 Aug 15.
4 A Contemporary Meta-Analysis of Antegrade versus Retrograde Cerebral Perfusion for Thoracic Aortic Surgery.Thorac Cardiovasc Surg. 2019 Aug;67(5):351-362. doi: 10.1055/s-0038-1632389. Epub 2018 Apr 6.
5 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
6 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
7 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
8 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
9 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
10 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
11 Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol. 2007 Jan-Feb;27(1):67-77. doi: 10.1002/jat.1200.
12 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
13 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
14 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
15 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
16 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
17 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
18 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
19 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
20 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
21 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
22 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
23 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
24 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
25 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.